Potential sources of overdiagnosis in histopathology

We highlight two potential sources of overdiagnosis related to histopathological examination of surgical specimens and terminology.1 Firstly, submitting multiple sections from background macroscopically normal tissue for microscopy is standard practice for histopathologists. These samples may contain coincidental in situ or invasive cancer. For example, background breast tissue from excision of a fibroadenoma may show …