revalence , Predictors , and Impact of onservative Medical Management for Patients ith Non – ST-Segment Elevation Acute Coronary yndromes Who Have Angiographically Documented ignificant Coronary Disease

ethods We evaluated 8,225 intermediateto high-risk NSTE ACS patients with at least 1 coronary leion 50% stenosis on early angiography from the SYNERGY (Superior Yield of the New Strategy of noxaparin, Revascularization, and Glycoprotein IIb/IIIa Inhibitors) trial (2001 to 2003), comparing patients reated with conservative medical management with those who underwent in-hospital percutaneous oronary intervention (PCI) or coronary artery bypass grafting (CABG) within 7 days of randomization.

[1]  R. Califf,et al.  Patients with non-ST-elevation acute coronary syndromes undergoing coronary artery bypass grafting in the modern era of antithrombotic therapy. , 2008, American heart journal.

[2]  William Wijns,et al.  [Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes]. , 2007, Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology.

[3]  S. Werns.  Benefit of Early Invasive Therapy in Acute Coronary Syndromes: A Meta-Analysis of Contemporary Randomized Clinical Trials , 2008 .

[4]  E. Antman,et al.  Prasugrel versus clopidogrel in patients with acute coronary syndromes. , 2007, The New England journal of medicine.

[5]  Tracy Y. Wang.  Challenges of Using Peri-procedural Myocardial Infarction as a Quality Measure Among Patients Undergoing Percutaneous Coronary Intervention , 2007 .

[6]  Manesh R. Patel,et al.  Changes in patterns of coronary revascularization strategies for patients with acute coronary syndromes (from the CRUSADE Quality Improvement Initiative). , 2007, The American journal of cardiology.

[7]  Christopher P Cannon,et al.  Meta-analysis of cardiovascular outcomes trials comparing intensive versus moderate statin therapy. , 2006, Journal of the American College of Cardiology.

[8]  P. Monteiro.  Impact of Early Coronary Artery Bypass Graft in an Unselected Acute Coronary Syndrome Patient Population , 2006, Circulation.

[9]  W. Gibler,et al.  Chronic kidney disease in patients with non-ST-segment elevation acute coronary syndromes. , 2006, The American journal of medicine.

[10]  K. Alexander,et al.  Excess dosing of antiplatelet and antithrombin agents in the treatment of non-ST-segment elevation acute coronary syndromes. , 2005, JAMA.

[11]  R. Califf,et al.  High-risk patients with acute coronary syndromes treated with low-molecular-weight or unfractionated heparin: outcomes at 6 months and 1 year in the SYNERGY trial. , 2005, JAMA.

[12]  Michal Abrahamowicz,et al.  Survival bias associated with time-to-treatment initiation in drug effectiveness evaluation: a comparison of methods. , 2005, American journal of epidemiology.

[13]  Deepak L. Bhatt,et al.  Utilization of Early Invasive Management Strategies for High-Risk Patients With Non–ST-Segment Elevation Acute Coronary Syndromes: Results From the CRUSADE Quality Improvement Initiative , 2004 .

[14]  S. Yusuf,et al.  Benefits and Risks of the Combination of Clopidogrel and Aspirin in Patients Undergoing Surgical Revascularization for Non–ST-Elevation Acute Coronary Syndrome: The Clopidogrel in Unstable angina to prevent Recurrent ischemic Events (CURE) Trial , 2004, Circulation.

[15]  Christopher P Cannon,et al.  Intensive versus moderate lipid lowering with statins after acute coronary syndromes. , 2004, The New England journal of medicine.

[16]  R. Califf,et al.  Enoxaparin vs unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndromes managed with an intended early invasive strategy: primary results of the SYNERGY randomized trial. , 2004, JAMA.

[17]  Á. Avezum,et al.  A validated prediction model for all forms of acute coronary syndrome:estimating the risk of 6-month postdischarge death in an international registry , 2004 .

[18]  M. Mamdani,et al.  Lipid-lowering therapy with statins in high-risk elderly patients: the treatment-risk paradox. , 2004, JAMA.

[19]  K. Fox,et al.  Interventional versus conservative treatment for patients with unstable angina or non-ST-elevation myocardial infarction: the British Heart Foundation RITA 3 randomised trial , 2002, The Lancet.

[20]  L. Parsons,et al.  Is there a benefit to early angiography in patients with ST-segment depression myocardial infarction? An observational study. , 2002, American heart journal.

[21]  F. Ragmin.  Invasive compared with non-invasive treatment in unstable coronary-artery disease: FRISC II prospective randomised multicentre study , 1999, The Lancet.

[22]  W. O’Neill,et al.  A prospective randomized trial of triage angiography in acute coronary syndromes ineligible for thrombolytic therapy. Results of the medicine versus angiography in thrombolytic exclusion (MATE) trial. , 1998, Journal of the American College of Cardiology.

[23]  L. Wilkins.  Effects of tissue plasminogen activator and a comparison of early invasive and conservative strategies in unstable angina and non-Q-wave myocardial infarction. Results of the TIMI IIIB Trial. Thrombolysis in Myocardial Ischemia. , 1994, Circulation.

[24]  J R Anderson,et al.  Analysis of survival by tumor response. , 1983, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.