Association of serious adverse events with Cheyne–Stokes respiration characteristics in patients with systolic heart failure and central sleep apnoea: A SERVE‐Heart Failure substudy analysis

Increases in Cheyne–Stokes respiration (CSR) cycle length (CL), lung‐to‐periphery circulation time (LPCT) and time to peak flow (TTPF) may reflect impaired cardiac function. This retrospective analysis used an automatic algorithm to evaluate baseline CSR‐related features and then determined whether these could be used to identify patients with systolic heart failure (HF) who experienced serious adverse events in the Treatment of Sleep‐Disordered Breathing with Predominant Central Sleep Apnea by Adaptive Servo Ventilation in Patients with Heart Failure (SERVE‐HF) substudy.

[1]  D. Horstkotte,et al.  Cheyne-Stokes respiration in heart failure: cycle length is dependent on left ventricular ejection fraction. , 2010, Sleep medicine.

[2]  D. Johns,et al.  Peripheral and central ventilatory responses in central sleep apnea with and without congestive heart failure. , 2000, American journal of respiratory and critical care medicine.

[3]  Patrick Levy,et al.  Adaptive Servo-Ventilation for Central Sleep Apnea in Systolic Heart Failure. , 2015, The New England journal of medicine.

[4]  Faizan Javed,et al.  ResCSRF: Algorithm to Automatically Extract Cheyne–Stokes Respiration Features From Respiratory Signals , 2018, IEEE Transactions on Biomedical Engineering.

[5]  R. Maestri,et al.  The development of hyperventilation in patients with chronic heart failure and Cheyne-Strokes respiration: a possible role of chronic hypoxia. , 1998, Chest.

[6]  M. Naughton,et al.  Effects of cardiac dysfunction on non-hypercapnic central sleep apnea. , 1998, Chest.

[7]  D. Horstkotte,et al.  Improvements of central respiratory events, Cheyne-Stokes respiration and oxygenation in patients hospitalized for acute decompensated heart failure. , 2016, Sleep medicine.

[8]  G. Tomlinson,et al.  Distinct Patterns of Hyperpnea During Cheyne-Stokes Respiration: Implication for Cardiac Function in Patients With Heart Failure. , 2017, Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.

[9]  Dieter Horstkotte,et al.  Sleep‐disordered breathing in patients with symptomatic heart failure A contemporary study of prevalence in and characteristics of 700 patients , 2007, European journal of heart failure.

[10]  A. Simonds,et al.  Adaptive servo‐ventilation for central sleep apnoea in systolic heart failure: results of the major substudy of SERVE‐HF , 2018, European journal of heart failure.

[11]  J. Döhring,et al.  Adaptive pressure support servo-ventilation: a novel treatment for Cheyne-Stokes respiration in heart failure. , 2001, American journal of respiratory and critical care medicine.

[12]  A. Xie,et al.  Cycle length of periodic breathing in patients with and without heart failure. , 1996, American journal of respiratory and critical care medicine.

[13]  A. Simonds,et al.  Rationale and design of the SERVE-HF study: treatment of sleep-disordered breathing with predominant central sleep apnoea with adaptive servo-ventilation in patients with chronic heart failure , 2013, European journal of heart failure.

[14]  E. Erdmann,et al.  Phenotyping of Sleep‐Disordered Breathing in Patients With Chronic Heart Failure With Reduced Ejection Fraction—the SchlaHF Registry , 2017, Journal of the American Heart Association.

[15]  J. Pépin,et al.  Prevalence and Impact of Central Sleep Apnea in Heart Failure , 2007 .

[16]  A. Simonds,et al.  Mechanisms underlying increased mortality risk in patients with heart failure and reduced ejection fraction randomly assigned to adaptive servoventilation in the SERVE-HF study: results of a secondary multistate modelling analysis. , 2016, The Lancet. Respiratory medicine.

[17]  M. Naughton,et al.  Influence of pulmonary capillary wedge pressure on central apnea in heart failure. , 1999, Circulation.

[18]  S. Javaheri A mechanism of central sleep apnea in patients with heart failure. , 1999, The New England journal of medicine.

[19]  R. Maestri,et al.  Association between hemodynamic impairment and Cheyne-Stokes respiration and periodic breathing in chronic stable congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. , 1999, The American journal of cardiology.