Synthesis and properties of waterborne polyurethane hydrogels for wound healing dressings.

To accomplish ideal wound healing dressing, a series of waterborne polyurethane (WBPU) hydrogels based on polyethylene glycol (PEG) were synthesized by polyaddition reaction in an emulsion system. The stable WBPU hydrogels which have remaining weight of above 85% were obtained. The effect of the soft segment (PEG) content on water absorbability of WBPU hydrogels was investigated. Water absorption % and equilibrium water content (%) of the WBPU hydrogel significantly increased in proportion to PEG content and the time of water-immersion. The maximum water absorption % and equilibrium water content (%) of WBPU hydrogels containing various PEG contents were in the range of 409-810% and 85-96%, respectively. The water vapor transmission rate of the WBPU hydrogels was found to be in the range of 1490-3118 g/m(2)/day. These results suggest that the WBPU hydrogels prepared in this study may have high potential as new wound dressing materials, which provide and maintain the adequate moist environment required to prevent scab formation and dehydration of the wound bed. By the wound healing evaluation using full-thickness rat model experiment, it was found that the wound covered with a typical WBPU hydrogel (HG-78 sample) was completely filled with new epithelium without any significant adverse reactions.

[1]  A. Fisher,et al.  In vitro assessment of water vapour transmission of synthetic wound dressings. , 1995, Biomaterials.

[2]  S. Purna,et al.  Collagen based dressings--a review. , 2000, Burns.

[3]  J. Lo,et al.  Dressing the part. , 1998, Dermatologic clinics.

[4]  J. Fulton,et al.  A Novel Occlusive Dressing for Skin Resurfacing , 1998, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[5]  Wei Lin,et al.  Preparation and Gel Properties of Poly[hydroxyethylmethacrylate-co-poly(ethylene glycol) methacrylate] Copolymeric Hydrogels by Photopolymerization , 2002 .

[6]  H. Suh,et al.  Bacterial adhesion on PEG modified polyurethane surfaces. , 1998, Biomaterials.

[7]  R. Moy,et al.  Delayed Infections Following Full‐Face CO2 Laser Resurfacing and Occlusive Dressing Use , 2000, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[8]  M. Ramos‐e‐Silva,et al.  New dressings, including tissue-engineered living skin. , 2002, Clinics in dermatology.

[9]  J. Evans,et al.  Principles of burn dressings. , 1985, Biomaterials.

[10]  A. Jayakrishnan,et al.  Evaluation of an in situ forming hydrogel wound dressing based on oxidized alginate and gelatin. , 2005, Biomaterials.

[11]  J. Rosiak,et al.  Hydrogels and their medical applications , 1999 .

[12]  G. Winter,et al.  Effect of Air Drying and Dressings on the Surface of a Wound , 1963, Nature.

[13]  S. Boyce,et al.  Structure of a collagen-GAG dermal skin substitute optimized for cultured human epidermal keratinocytes. , 1988, Journal of biomedical materials research.

[14]  V. Jones,et al.  Topical treatment: which dressing to choose , 2000, Diabetes/metabolism research and reviews.

[15]  C. Su,et al.  Fungal mycelia as the source of chitin and polysaccharides and their applications as skin substitutes. , 1997, Biomaterials.

[16]  B. Kickhöfen,et al.  Chemical and physical properties of a hydrogel wound dressing. , 1986, Biomaterials.

[17]  B. Pruitt,et al.  Characteristics and uses of biologic dressings and skin substitutes. , 1984, Archives of surgery.

[18]  Y. M. Lee,et al.  Studies on gelatin-containing artificial skin: II. Preparation and characterization of cross-linked gelatin-hyaluronate sponge. , 1999, Journal of biomedical materials research.

[19]  G. Nilsson,et al.  The evaporative water loss from burns and the water-vapour permeability of grafts and artificial membranes used in the treatment of burns , 1977 .

[20]  Abul Kalam Azad,et al.  Chitosan membrane as a wound-healing dressing: characterization and clinical application. , 2004, Journal of biomedical materials research. Part B, Applied biomaterials.

[21]  J. Evans,et al.  The preclinical evaluation of the water vapour transmission rate through burn wound dressings. , 1987, Biomaterials.

[22]  Glenn D Prestwich,et al.  In situ crosslinkable hyaluronan hydrogels for tissue engineering. , 2004, Biomaterials.

[23]  D. M. Kim,et al.  Platelet adhesion onto segmented polyurethane film surfaces modified by addition and crosslinking of PEO-containing block copolymers. , 2000, Biomaterials.

[24]  T. Stashak,et al.  Update on wound dressings: Indications and best use , 2004 .

[25]  G. Winter,et al.  Formation of the Scab and the Rate of Epithelization of Superficial Wounds in the Skin of the Young Domestic Pig , 1962, Nature.

[26]  C. Choate.  Wound dressings. A comparison of classes and their principles of use. , 1994, Journal of the American Podiatric Medical Association (Print).

[27]  W. Eaglstein,et al.  The effect of occlusive dressings on collagen synthesis and re-epithelialization in superficial wounds. , 1983, The Journal of surgical research.

[28]  R Tubo,et al.  Alternative delivery of keratinocytes using a polyurethane membrane and the implications for its use in the treatment of full-thickness burn injury. , 1998, Burns : journal of the International Society for Burn Injuries.

[29]  V. Falanga,et al.  Growth factors. Their biology and promise in dermatologic diseases and tissue repair. , 1989, Archives of dermatology.

[30]  F. Yoshii,et al.  Electron beam crosslinked PEO and PEO/PVA hydrogels for wound dressing , 1999 .

[31]  O. Halkka.  Equilibrium Populations of Philaenus spumarius L. , 1962, Nature.