2002: Signaling Breakthroughs of the Year

The editors of Science's STKE would like to welcome you back to a new year in signal transduction with a feature on highlights of signaling research in 2002. To compile our feature on the Signaling Breakthroughs of the Year, we contacted leading researchers in various disciplines of signal

[1]  Jian Yang,et al.  Alterations in Conserved Kir Channel-PIP2 Interactions Underlie Channelopathies , 2002, Neuron.

[2]  D. Clapham,et al.  The TRPM7 channel is inactivated by PIP2 hydrolysis , 2002, Nature Cell Biology.

[3]  A. Konnerth,et al.  Neurotrophin-evoked depolarization requires the sodium channel NaV1.9 , 2002, Nature.

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[6]  Jian Yang,et al.  Dual regulation of voltage-gated calcium channels by PtdIns(4,5)P2 , 2002, Nature.

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[10]  Junichi Takagi,et al.  Global Conformational Rearrangements in Integrin Extracellular Domains in Outside-In and Inside-Out Signaling , 2002, Cell.

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[12]  C. Ryan,et al.  The systemin receptor SR160 from Lycopersicon peruvianum is a member of the LRR receptor kinase family , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[13]  David E. Clapham,et al.  TRPV3 is a calcium-permeable temperature-sensitive cation channel , 2002, Nature.

[14]  M. Mayer,et al.  Mechanism of glutamate receptor desensitization , 2002, Nature.

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[16]  Gary G. Borisy,et al.  Antagonism between Ena/VASP Proteins and Actin Filament Capping Regulates Fibroblast Motility , 2002, Cell.

[17]  David Mackey,et al.  RIN4 Interacts with Pseudomonas syringae Type III Effector Molecules and Is Required for RPM1-Mediated Resistance in Arabidopsis , 2002, Cell.

[18]  A. Kereszt,et al.  A receptor kinase gene regulating symbiotic nodule development , 2002, Nature.

[19]  D. Hilgemann,et al.  The Complex and Intriguing Lives of PIP2 with Ion Channels and Transporters , 2001, Science's STKE.

[20]  T. Nomura,et al.  Cloning the Tomato Curl3 Gene Highlights the Putative Dual Role of the Leucine-Rich Repeat Receptor Kinase tBRI1/SR160 in Plant Steroid Hormone and Peptide Hormone Signaling Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.006379. , 2002, The Plant Cell Online.

[21]  K. Mikoshiba,et al.  Two-state Conformational Changes in Inositol 1,4,5-Trisphosphate Receptor Regulated by Calcium* , 2002, The Journal of Biological Chemistry.

[22]  Jonathan D. G. Jones,et al.  Regulatory Role of SGT1 in Early R Gene-Mediated Plant Defenses , 2002, Science.

[23]  Bert W O'Malley,et al.  Coordinate Regulation of Transcription and Splicing by Steroid Receptor Coregulators , 2002, Science.

[24]  P. Várnai,et al.  Visualizing Cellular Phosphoinositide Pools with GFP-Fused Protein-Modules , 2002, Science's STKE.

[25]  Keisuke Kuida,et al.  Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome , 2002, Nature.

[26]  Hong Ma,et al.  The SCF(COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis. , 2002, The Plant cell.

[27]  S. Snyder,et al.  Phospholipase C-γ Is Required for Agonist-Induced Ca2+ Entry , 2002, Cell.

[28]  S. Dowler,et al.  Protein Lipid Overlay Assay , 2002, Science's STKE.

[29]  T. Wagenknecht,et al.  Three-dimensional Reconstruction of the Recombinant Type 2 Ryanodine Receptor and Localization of Its Divergent Region 1* , 2002, The Journal of Biological Chemistry.

[30]  Ximena Opitz-Araya,et al.  Requirement for Caspase-2 in Stress-Induced Apoptosis Before Mitochondrial Permeabilization , 2002, Science.

[31]  S. Tabata,et al.  Shoot control of root development and nodulation is mediated by a receptor-like kinase , 2002, Nature.

[32]  M. Ohmori,et al.  HAR1 mediates systemic regulation of symbiotic organ development , 2002, Nature.

[33]  N. Fedoroff.  Cross-Talk in Abscisic Acid Signaling , 2002, Science's STKE.

[34]  John B. Hogenesch,et al.  A Heat-Sensitive TRP Channel Expressed in Keratinocytes , 2002, Science.

[35]  K. Mikoshiba,et al.  Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand , 2002, Nature.

[36]  P. Anand,et al.  TRPV3 is a temperature-sensitive vanilloid receptor-like protein , 2002, Nature.

[37]  Lei Li,et al.  Distinct roles for jasmonate synthesis and action in the systemic wound response of tomato , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[38]  P. McIntyre,et al.  A TRP Channel that Senses Cold Stimuli and Menthol , 2002, Cell.