Reperfusion after cerebral ischemia: influence of duration of ischemia.

The influence of the duration of ischemia on the pattern of cerebral blood flow in recirculation was studied in anesthetised rats. Severe incomplete cerebral ischemia (mean ischemic flow = 5.8 +/- 0.4 ml/100 g/min) was produced by four-vessel occlusion and recirculation permitted after 15, 30 or 60 minutes ischemia. All three groups showed an immediate hyperemia followed by hypoperfusion. Hyperemia was maximal following 15 minutes ischemia and least pronounced following 60 minutes ischemia (p = 0.0249). Hypoperfusion started most quickly following 15 minutes ischemia and was delayed following 60 minutes ischemia (p less than 0.001). In established hypoperfusion there was no difference in flow between the three groups. The possible mechanisms of these changes in flow are discussed.

[1]  R. Russell,et al.  Duration of Ischemia Influences the Development and Resolution of Ischemic Brain Edema , 2022 .

[2]  B. Siesjö.  Cell Damage in the Brain: A Speculative Synthesis , 1984, Acta psychiatrica Scandinavica. Supplementum.

[3]  H. Crockard,et al.  Evolution and resolution of oedema following severe temporary cerebral ischaemia in the gerbil. , 1984, Journal of neurology, neurosurgery, and psychiatry.

[4]  B. Siesjö,et al.  Recirculation in the Rat Brain following Incomplete Ischemia , 1983, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[5]  B. Siesjö,et al.  Local Cerebral Blood Flow in the Recovery Period following Complete Cerebral Ischemia in the Rat , 1983, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[6]  T. Furlow.  Cerebral ischemia produced by four‐vessel occlusion in the rat: a quantitative evaluation of cerebral blood flow. , 1982, Stroke.

[7]  K. Hossmann.  Treatment of Experimental Cerebral Ischemia , 1982, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[8]  F. Plum,et al.  Edema and Vascular Permeability in Cerebral Ischemia: Comparison Between Ischemic Neuronal Damage and Infarction , 1982, Journal of neuropathology and experimental neurology.

[9]  Fred Plum,et al.  Temporal profile of neuronal damage in a model of transient forebrain ischemia , 1982, Annals of neurology.

[10]  W. Pulsinelli,et al.  Regional cerebral blood flow and glucose metabolism following transient forebrain ischemia , 1982, Annals of neurology.

[11]  M. Ohata,et al.  Journal of Cerebral Blood Flow and Metabolism Effects of Immobilization Stress on Regional Cerebral Blood Flow in the Conscious Rat , 2022 .

[12]  W. Pulsinelli,et al.  Regional Protein Synthesis in Rat Brain Following Acute Hemispheric Ischemia , 1980, Journal of neurochemistry.

[13]  K. Tanaka,et al.  “Low Perfusion Hyperemia” Following Middle Cerebral Arterial Occlusion In Cats of Different Age Groups , 1980, Stroke.

[14]  D. Lampard,et al.  Local Cerebral Blood Flow Following Transient Cerebral Ischemia: I. Onset of Impaired Reperfusion within the First Hour Following Global Ischemia , 1980, Stroke.

[15]  David E. Levy,et al.  Delayed postischemic hypoperfusion , 1979, Neurology.

[16]  K. Hossmann,et al.  Brain Blood Flow and Metabolism After Global Ischemia and Post‐insult Thiopental Therapy in Monkeys , 1979, Stroke.

[17]  A. Ames,et al.  Cerebral Blood Flow Immediately Following Brief Circulatory Stasis , 1979, Stroke.

[18]  J. Brierley,et al.  A New Model of Bilateral Hemispheric Ischemia in the Unanesthetized Rat , 1979, Stroke.

[19]  K. Hossmann.  Cerebral Dysfunction Related to Local and Global Ischemia of the Brain , 1979 .

[20]  B. Siesjö,et al.  Effects of phenobarbital in cerebral ischemia. Part I: cerebral energy metabolism during pronounced incomplete ischemia. , 1978, Stroke.

[21]  K. Hossmann,et al.  Blood Recirculation and Pharmacological Responsiveness of the Cerebral Vasculature Following Prolonged Ischemia of Cat Brain , 1977, Stroke.

[22]  S. Rehncrona,et al.  Postischemic cerebral blood flow and oxygen utilization rate in rats anesthetized with nitrous oxide or phenobarbital. , 1977, Acta physiologica Scandinavica.

[23]  K. Hossmann,et al.  Coagulopathy Following Experimental Cerebral Ischemia , 1977, Stroke.

[24]  T. Duffy,et al.  CEREBRAL ENERGY METABOLISM DURING TRANSIENT ISCHEMIA AND RECOVERY IN THE GERBIL 1 , 1977, Journal of neurochemistry.

[25]  K. Hossmann.  Total Ischemia of the Brain , 1977 .

[26]  Katsuharukimoto,et al.  Cerebral Uptake of Glucose and Oxygen in the Cat Brain After Prolonged Ischemia , 1976 .

[27]  P. Safar,et al.  Amelioration of brain damage after 12 minutes' cardiac arrest in dogs. , 1976, Archives of neurology.

[28]  T. Sundt,et al.  Microcirculatory Obstruction in Focal Cerebral Ischemia: An Electron Microscopic Investigation in Monkeys , 1976, Stroke.

[29]  K. Hossmann.  Development and Resolution of Ischemic Brain Swelling , 1976 .

[30]  R. Osburne,et al.  Cerebral blood flow. A predictor of recovery from ischemia in the gerbil. , 1975, Archives of neurology.

[31]  G. Teasdale,et al.  Effects of increased arterial pressure on blood flow in the damaged brain. , 1975, Journal of neurology, neurosurgery, and psychiatry.

[32]  J. Wade,et al.  No-flow state following cerebral ischemia. Role of increase in potassium concentration in brain interstitial fluid. , 1975, Archives of neurology.

[33]  P. Safar,et al.  Global Ischemia in Dogs: Intracranial Pressures, Brain Blood Flow and Metabolism , 1975, Stroke.

[34]  J. Hekmatpanah.  Cerebral blood flow dynamics in hypotension and cardiac arrest. , 1974, Neurology.

[35]  L. Symon,et al.  The Hydrogen Clearance Method in Assessment of Blood Flow in Cortex, White Matter and Deep Nuclei of Baboons , 1973, Stroke.

[36]  R. Myers,et al.  The topography of impaired micro vascular perfusion in the primate brain following total circulatory arrest , 1972, Neurology.

[37]  A. Ames,et al.  Studies on Mechanisms of Impairment of Cerebral Circulation Following Ischemia: Effect of Hemodilution and Perfusion Pressure , 1972, Stroke.

[38]  R. Cantu,et al.  Reversibility of experimental cerebrovascular obstruction induced by complete ischemia. , 1969, Journal of neurosurgery.

[39]  M. Kowada,et al.  Cerebral ischemia. II. The no-reflow phenomenon. , 1968, The American journal of pathology.

[40]  M. Kowada,et al.  Cerebral ischemia. III. Vascular changes. , 1968, The American journal of pathology.

[41]  R. Berliner,et al.  Measurement of Local Blood Flow with Hydrogen Gas , 1964, Circulation research.

[42]  S. Levine,et al.  Anoxic-ischemic encephalopathy in rats. , 1960, The American journal of pathology.

[43]  K. Dixon.  Anaerobic leakage of potassium from brain. , 1949, The Biochemical journal.