The roles of the prostaglandin D2 receptors DP1 and CRTH2 in promoting allergic responses

[1]  R. Pettipher,et al.  A paracrine role for chemoattractant receptor‐homologous molecule expressed on T helper type 2 cells (CRTH2) in mediating chemotactic activation of CRTH2+ CD4+ T helper type 2 lymphocytes , 2007, Immunology.

[2]  G. Geisslinger,et al.  PGD2 metabolism in plasma: kinetics and relationship with bioactivity on DP1 and CRTH2 receptors. , 2007, Biochemical pharmacology.

[3]  Trevor T. Hansel,et al.  Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases , 2007, Nature Reviews Drug Discovery.

[4]  L. Xue,et al.  Inhibition of PI3K and calcineurin suppresses chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)-dependent responses of Th2 lymphocytes to prostaglandin D(2). , 2007, Biochemical pharmacology.

[5]  J. M. Mathiesen,et al.  Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation , 2007, Respiratory research.

[6]  H. Hammad,et al.  Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells , 2007, The Journal of experimental medicine.

[7]  J. Pease,et al.  Contrary prostaglandins: the opposing roles of PGD2 and its metabolites in leukocyte function , 2007, Journal of leukocyte biology.

[8]  R. Young,et al.  Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524). , 2007, Journal of medicinal chemistry.

[9]  J. Lawson,et al.  Agonist and Antagonist Effects of 15R-Prostaglandin (PG) D2 and 11-Methylene-PGD2 on Human Eosinophils and Basophils , 2007, Journal of Pharmacology and Experimental Therapeutics.

[10]  N. Kadowaki,et al.  IgE-activated mast cells in combination with pro-inflammatory factors induce Th2-promoting dendritic cells. , 2006, International immunology.

[11]  D. Connolly,et al.  Langerhans cells release prostaglandin D2 in response to nicotinic acid. , 2006, The Journal of investigative dermatology.

[12]  L. Xue,et al.  A dominant role for chemoattractant receptor‐homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2+ CD4+ Th2 lymphocytes in response to mast cell supernatants , 2006, Immunology.

[13]  M. Lutz,et al.  The mast cell mediator PGD2 suppresses IL-12 release by dendritic cells leading to Th2 polarized immune responses in vivo. , 2006, Immunobiology.

[14]  K. Hirokawa,et al.  Prostaglandin D2 Plays an Essential Role in Chronic Allergic Inflammation of the Skin via CRTH2 Receptor1 , 2006, The Journal of Immunology.

[15]  E. Knol,et al.  IgE-Mediated Allergen Presentation and Blocking Antibodies: Regulation of T-Cell Activation in Allergy , 2006, International Archives of Allergy and Immunology.

[16]  C. J. Barnes,et al.  Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells. , 2006, Immunity.

[17]  G. O'neill,et al.  Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[18]  E. Kostenis,et al.  Emerging roles of DP and CRTH2 in allergic inflammation. , 2006, Trends in molecular medicine.

[19]  T. Jacques,et al.  Essential role for hematopoietic prostaglandin D2 synthase in the control of delayed type hypersensitivity. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[20]  Ashley A. Barnes,et al.  9α,11β‐PGF2 and its stereoisomer PGF2α are novel agonists of the chemoattractant receptor, CRTH2 , 2006 .

[21]  Michael G. Hunter,et al.  Prostaglandin D2 Causes Preferential Induction of Proinflammatory Th2 Cytokine Production through an Action on Chemoattractant Receptor-Like Molecule Expressed on Th2 Cells , 2005, The Journal of Immunology.

[22]  C. Hawrylowicz,et al.  Functional plasticity of human respiratory tract dendritic cells: GM-CSF enhances T(H)2 development. , 2005, The Journal of allergy and clinical immunology.

[23]  M. Whittaker,et al.  Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2. , 2005, Journal of medicinal chemistry.

[24]  E. Fuse,et al.  Inhibitory Effect of the 4-Aminotetrahydroquinoline Derivatives, Selective Chemoattractant Receptor-Homologous Molecule Expressed on T Helper 2 Cell Antagonists, on Eosinophil Migration Induced by Prostaglandin D2 , 2005, Journal of Pharmacology and Experimental Therapeutics.

[25]  D. Robinson,et al.  Thymic Stromal Lymphopoietin Expression Is Increased in Asthmatic Airways and Correlates with Expression of Th2-Attracting Chemokines and Disease Severity1 , 2005, The Journal of Immunology.

[26]  D. Denis,et al.  Identification of a Potent and Selective Synthetic Agonist at the CRTH2 Receptor , 2005, Molecular Pharmacology.

[27]  M. Pichavant,et al.  Prostaglandin D2 affects the differentiation and functions of human dendritic cells: impact on the T cell response , 2005, European journal of immunology.

[28]  L. Bacharier,et al.  The atopic march: the pattern of allergic disease development in childhood. , 2005, Immunology and allergy clinics of North America.

[29]  Q. Hamid,et al.  Effects of Prostaglandin D2, 15-Deoxy-Δ12,14-prostaglandin J2, and Selective DP1 and DP2 Receptor Agonists on Pulmonary Infiltration of Eosinophils in Brown Norway Rats , 2005, Journal of Pharmacology and Experimental Therapeutics.

[30]  M. Willart,et al.  In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma , 2005, The Journal of experimental medicine.

[31]  S. Fleury,et al.  Activation of the Prostaglandin D2 Receptor DP2/CRTH2 Increases Allergic Inflammation in Mouse 1 , 2005, The Journal of Immunology.

[32]  B. Lambrecht Dendritic cells and the regulation of the allergic immune response , 2005, Allergy.

[33]  Yusuke Suzuki,et al.  Prostaglandin D2-Induced Eosinophilic Airway Inflammation Is Mediated by CRTH2 Receptor , 2005, Journal of Pharmacology and Experimental Therapeutics.

[34]  E. Kostenis,et al.  Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist. , 2005, Journal of medicinal chemistry.

[35]  Chris Allan,et al.  Delta12-prostaglandin D2 is a potent and selective CRTH2 receptor agonist and causes activation of human eosinophils and Th2 lymphocytes. , 2005, Prostaglandins & other lipid mediators.

[36]  F. Gantner,et al.  CRTH2 is a prominent effector in contact hypersensitivity-induced neutrophil inflammation. , 2004, International immunology.

[37]  S. Dahlén,et al.  Measuring quality of life in patients with sleep apnoea: whose life is it anyway? , 2004, Thorax.

[38]  Masataka Nakamura,et al.  Effects of prostaglandin D2 on helper T cell functions. , 2004, Biochemical and biophysical research communications.

[39]  H. Hammad,et al.  Activation of the D Prostanoid Receptor 1 Regulates Immune and Skin Allergic Responses1 , 2004, The Journal of Immunology.

[40]  G. Sturm,et al.  11-Dehydro-thromboxane B2, a Stable Thromboxane Metabolite, Is a Full Agonist of Chemoattractant Receptor-homologous Molecule Expressed on TH2 Cells (CRTH2) in Human Eosinophils and Basophils* , 2004, Journal of Biological Chemistry.

[41]  H. Karasuyama,et al.  IgE‐dependent enhancement of Th2 cell‐mediated allergic inflammation in the airways , 2004, Clinical and experimental immunology.

[42]  P. Barnes New drugs for asthma , 2004, Nature Reviews Drug Discovery.

[43]  H. Hammad,et al.  Prostaglandin D2 Inhibits Airway Dendritic Cell Migration and Function in Steady State Conditions by Selective Activation of the D Prostanoid Receptor 1 1 , 2003, The Journal of Immunology.

[44]  H. Karasuyama,et al.  Role of IgE in Th2 Cell-Mediated Allergic Airway Inflammation , 2003, International Archives of Allergy and Immunology.

[45]  A. Hartnell,et al.  Δ12-Prostaglandin J2, a Plasma Metabolite of Prostaglandin D2, Causes Eosinophil Mobilization from the Bone Marrow and Primes Eosinophils for Chemotaxis1 , 2003, The Journal of Immunology.

[46]  S. Narumiya,et al.  Prostaglandin D2 inhibits the production of interleukin‐12 in murine dendritic cells through multiple signaling pathways , 2003, European journal of immunology.

[47]  A. Szczeklik,et al.  A controlled study of 9alpha,11beta-PGF2 (a prostaglandin D2 metabolite) in plasma and urine of patients with bronchial asthma and healthy controls after aspirin challenge. , 2003, The Journal of allergy and clinical immunology.

[48]  F. Gantner,et al.  An Orally Bioavailable Small Molecule Antagonist of CRTH2, Ramatroban (BAY u3405), Inhibits Prostaglandin D2-Induced Eosinophil Migration in Vitro , 2003, Journal of Pharmacology and Experimental Therapeutics.

[49]  A. Hartnell,et al.  Causes Eosinophil Mobilization from the Bone Marrow and Primes Eosinophils for Chemotaxis , 2003 .

[50]  G. O'neill,et al.  Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2 , 2002, British journal of pharmacology.

[51]  T. Williams,et al.  Indomethacin Causes Prostaglandin D2-like and Eotaxin-like Selective Responses in Eosinophils and Basophils* , 2002, The Journal of Biological Chemistry.

[52]  J. Rokach,et al.  15-Deoxy-Δ12,1412,14-prostaglandins D2 and J2 Are Potent Activators of Human Eosinophils1 , 2002, The Journal of Immunology.

[53]  Masataka Nakamura,et al.  Cutting Edge: Agonistic Effect of Indomethacin on a Prostaglandin D2 Receptor, CRTH2 , 2002, The Journal of Immunology.

[54]  Yoshihiro Urade,et al.  Pronounced Eosinophilic Lung Inflammation and Th2 Cytokine Release in Human Lipocalin-Type Prostaglandin D Synthase Transgenic Mice1 , 2002, The Journal of Immunology.

[55]  Julian Vasilescu,et al.  15-Deoxy-delta 12,14-prostaglandins D2 and J2 are potent activators of human eosinophils. , 2002, Journal of immunology.

[56]  H. Young,et al.  Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization. , 2001, The Journal of clinical investigation.

[57]  G. O'neill,et al.  Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP. , 2001, The Journal of allergy and clinical immunology.

[58]  J. Bonnefoy,et al.  Histamine Polarizes Human Dendritic Cells into Th2 Cell-Promoting Effector Dendritic Cells , 2001, The Journal of Immunology.

[59]  M. Diamond,et al.  Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor. , 2001, Blood.

[60]  K. Yasui,et al.  Prevention of allergic inflammation by a novel prostaglandin receptor antagonist, S-5751. , 2001, The Journal of pharmacology and experimental therapeutics.

[61]  L. Edwards,et al.  Low-dose fluticasone propionate compared with montelukast for first-line treatment of persistent asthma: a randomized clinical trial. , 2001, The Journal of allergy and clinical immunology.

[62]  K. Sugamura,et al.  Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2 , 2001, The Journal of experimental medicine.

[63]  A. Ford-hutchinson,et al.  The human prostanoid DP receptor stimulates mucin secretion in LS174T cells , 2000, British journal of pharmacology.

[64]  J. Wallace,et al.  Cyclooxygenase-2-derived prostaglandin D(2) is an early anti-inflammatory signal in experimental colitis. , 2000, American journal of physiology. Gastrointestinal and liver physiology.

[65]  S. Narumiya,et al.  Prostaglandin D2 as a mediator of allergic asthma. , 2000, Science.

[66]  K. Sugamura,et al.  Cutting Edge: Differential Production of Prostaglandin D2 by Human Helper T Cell Subsets , 2000, The Journal of Immunology.

[67]  S. Reddy,et al.  Genetic evidence for distinct roles of COX-1 and COX-2 in the immediate and delayed phases of prostaglandin synthesis in mast cells. , 1999, Biochemical and biophysical research communications.

[68]  K. Sugamura,et al.  CRTH2, an orphan receptor of T‐helper‐2‐cells, is expressed on basophils and eosinophils and responds to mast cell‐derived factor(s) , 1999, FEBS letters.

[69]  D. Gilroy,et al.  Inducible cyclooxygenase may have anti-inflammatory properties , 1999, Nature Medicine.

[70]  K. Sugamura,et al.  Selective expression of a novel surface molecule by human Th2 cells in vivo. , 1999, Journal of immunology.

[71]  L. Walch,et al.  Prostanoid receptors involved in the relaxation of human pulmonary vessels , 1999, British journal of pharmacology.

[72]  A. Konno,et al.  The effect of ramatroban (BAY u 3405), a thromboxane A2 receptor antagonist, on nasal cavity volume and minimum cross-sectional area and nasal mucosal hemodynamics after nasal mucosal allergen challenge in patients with perennial allergic rhinitis. , 1998, Acta oto-laryngologica. Supplementum.

[73]  P. Howarth Mediators of nasal blockage in allergic rbtis , 1997 .

[74]  A. Sousa,et al.  Enhanced expression of cyclo-oxygenase isoenzyme 2 (COX-2) in asthmatic airways and its cellular distribution in aspirin-sensitive asthma. , 1997, Thorax.

[75]  H. Boushey,et al.  The effect of an anti-IgE monoclonal antibody on the early- and late-phase responses to allergen inhalation in asthmatic subjects. , 1997, American journal of respiratory and critical care medicine.

[76]  S. Durham,et al.  Effect of cyclosporin A on the allergen-induced late asthmatic reaction. , 1997, Thorax.

[77]  P. Howarth Mediators of nasal blockage in allergic rhinitis. , 1997, Allergy.

[78]  S. Dahlén,et al.  Increased urinary excretion of the prostaglandin D2 metabolite 9 alpha, 11 beta-prostaglandin F2 after aspirin challenge supports mast cell activation in aspirin-induced airway obstruction. , 1996, The Journal of allergy and clinical immunology.

[79]  A. Kataura,et al.  Effects of thromboxane A2 receptor antagonist (Bay u 3405) on nasal symptoms after antigen challenge in sensitized guinea pigs. , 1996, International archives of allergy and immunology.

[80]  H. Takeda,et al.  The effect of a thromboxane A2 receptor antagonist BAY-u-3405 on experimental allergic reactions. , 1995, Prostaglandins.

[81]  P. Gardiner,et al.  BAY u3405, a potent and selective thromboxane A2 receptor antagonist on airway smooth muscle in vitro , 1991, British journal of pharmacology.

[82]  R. Matran,et al.  Effect of nedocromil sodium on allergen‐, PAF‐, histamine‐ and bradykinin‐induced airways vasodilatation and pulmonary obstruction in the pig , 1991, British journal of pharmacology.

[83]  A. Kagey‐Sobotka,et al.  Prednisone inhibits the appearance of inflammatory mediators and the influx of eosinophils and basophils associated with the cutaneous late-phase response to allergen. , 1991, Journal of immunology.

[84]  P. Howarth,et al.  The comparative nasal effects of prostaglandin D2 in normal and rhinitic subjects. , 1991, Advances in prostaglandin, thromboxane, and leukotriene research.

[85]  W. Doyle,et al.  Physiologic responses to intranasal dose-response challenges with histamine, methacholine, bradykinin, and prostaglandin in adult volunteers with and without nasal allergy. , 1990, The Journal of allergy and clinical immunology.

[86]  J. Widdicombe,et al.  Nasal pathophysiology. Discussion , 1990 .

[87]  J. Widdicombe Nasal pathophysiology. , 1990, Respiratory medicine.

[88]  A. Robertson,et al.  The classification of prostaglandin DP‐receptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist , 1989, British journal of pharmacology.

[89]  B. Whittle,et al.  Antagonism of PGD2 vasodepressor responses in the rat in vivo by the novel, selective antagonist, BW A868C , 1989, British journal of pharmacology.

[90]  R. Naclerio,et al.  Mediator release after nasal airway challenge with allergen. , 2015, The American review of respiratory disease.

[91]  J. Murray,et al.  Release of prostaglandin D2 into human airways during acute antigen challenge. , 1986, The New England journal of medicine.

[92]  J. O'grady,et al.  Effect of a hydantoin prostaglandin analogue, BW245C, during oral dosing in man. , 1985, Prostaglandins.

[93]  C. Dollery,et al.  Effects of intravenous infusions of prostaglandin D2 in man. , 1984, Prostaglandins.

[94]  J. Vane,et al.  Platelet and cardiovascular activity of the hydantoin BW245C, a potent prostaglandin analogue. , 1983, Prostaglandins.

[95]  J. Oates,et al.  Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE. , 1982, Journal of immunology.

[96]  R. Naclerio,et al.  The role of prostaglandin D2 in IgE-mediated reactions in man. , 1982, Transactions of the Association of American Physicians.