Oxidation of tris-(p-carboxyltetrathiaaryl)methyl radical EPR probes: evidence for their oxidative decarboxylation and molecular origin of their specific ability to react with O2*-.

Tris-(p-carboxyltetrathiaaryl)methyl radical EPR probes are very efficiently oxidized by superoxide and alkylperoxyl radicals with selective formation of quinone-methide products; this should explain the previously reported specific measurement of O2*- using these EPR probes.

[1]  C. Rovira,et al.  Reactivity of superoxide anion radical with a perchlorotriphenylmethyl (trityl) radical. , 2008, The journal of physical chemistry. B.

[2]  J. Clément,et al.  Chapter 2:Advances in Spin Trapping , 2006 .

[3]  Bernard Gallez,et al.  Assessment of tumor oxygenation by electron paramagnetic resonance: principles and applications , 2004, NMR in biomedicine.

[4]  J. Zweier,et al.  Reaction of superoxide with trityl radical: implications for the determination of superoxide by spectrophotometry. , 2004, Archives of biochemistry and biophysics.

[5]  J. Zweier,et al.  Application of a trityl-based radical probe for measuring superoxide. , 2003, Free radical biology & medicine.

[6]  Howard J Halpern,et al.  General synthesis of persistent trityl radicals for EPR imaging of biological systems. , 2002, The Journal of organic chemistry.

[7]  James B. Mitchell,et al.  Overhauser enhanced magnetic resonance imaging for tumor oximetry: Coregistration of tumor anatomy and tissue oxygen concentration , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[8]  M. Kirsch,et al.  The Pathobiochemistry of Nitrogen Dioxide , 2002, Biological chemistry.

[9]  J S Petersson,et al.  EPR and DNP properties of certain novel single electron contrast agents intended for oximetric imaging. , 1998, Journal of magnetic resonance.

[10]  E. Niki.  Free radical initiators as source of water- or lipid-soluble peroxyl radicals. , 1990, Methods in enzymology.

[11]  D. Griller,et al.  Persistent carbon-centered radicals , 1976 .