Protein import into the cell nucleus.

It has been known for some time that the uptake of proteins by the nucleus is extremely selective (Gurdon 1970; Bonner 1975b) and that mature nuclear proteins are able to accumulate in the nucleus (Gurdon 1970; Bonner 1975b; De Robertis et al 1978; Dabauvalle & Franke 1982). Nuclear proteins must therefore contain within their final structure a signal that specifies selective accumulation in the nucleus (De Robertis et al 1978). The study of the mechanisms by which proteins are selectively accumu­ lated in the cell nucleus has lagged behind the study of other transport processes, such as those that direct proteins to the cell exterior or to cytoplasmic organelles. The late development of this field may be due to the widespread acceptance of a model for nuclear localization in which

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