Biomarkers in Lung Diseases : from Pathogenesis to Prediction to New Therapies Macrophage migration inhibitory factor deficiency in chronic obstructive pulmonary disease

Maor Sauler, Lin Leng, Mark Trentalange, Maria Haslip, Peiying Shan, Marta Piecychna, Yi Zhang, Nathaniel Andrews, Praveen Mannam, Heather Allore, Terri Fried, Richard Bucala, and Patty J. Lee Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut; Section of Rheumatology, Department of Medicine, Yale University, New Haven, Connecticut; and Section of Geriatric Medicine: Claude D. Pepper Older Americans Independent Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut

[1]  Nichole Reisdorph,et al.  Peripheral blood mononuclear cell gene expression in chronic obstructive pulmonary disease. , 2013, American journal of respiratory cell and molecular biology.

[2]  R. Weichselbaum,et al.  Role of migratory inhibition factor in age-related susceptibility to radiation lung injury via NF-E2-related factor-2 and antioxidant regulation. , 2013, American journal of respiratory cell and molecular biology.

[3]  J. Campisi Aging, cellular senescence, and cancer. , 2013, Annual review of physiology.

[4]  G. Washko,et al.  TLR4 deficiency promotes autophagy during cigarette smoke-induced pulmonary emphysema. , 2012, American journal of physiology. Lung cellular and molecular physiology.

[5]  D. Postma,et al.  Toll-Like Receptor (TLR2 and TLR4) Polymorphisms and Chronic Obstructive Pulmonary Disease , 2012, PloS one.

[6]  R. Bucala The MIF Handbook , 2012 .

[7]  M. Decramer,et al.  Chronic obstructive pulmonary disease , 2012, The Lancet.

[8]  K. Kubo,et al.  The association of Toll-like receptor 4 gene polymorphisms with the development of emphysema in Japanese subjects: a case control study , 2012, BMC Research Notes.

[9]  G. Mensah,et al.  Geographic Variations in Heart Failure Hospitalizations Among Medicare Beneficiaries in the Tennessee Catchment Area , 2012, The American journal of the medical sciences.

[10]  Ruth R. Montgomery,et al.  Dual effect of the macrophage migration inhibitory factor gene on the development and severity of human systemic lupus erythematosus. , 2011, Arthritis and rheumatism.

[11]  Rugang Zhang,et al.  Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis. , 2011, Molecular cell.

[12]  Bartolome Celli,et al.  Induced sputum genes associated with spirometric and radiological disease severity in COPD ex-smokers , 2011, Thorax.

[13]  D. Peeper,et al.  The essence of senescence. , 2010, Genes & development.

[14]  T. Betsuyaku,et al.  Cigarette smoke induces nucleic-acid oxidation in lung fibroblasts. , 2010, American journal of respiratory cell and molecular biology.

[15]  Jun Ren,et al.  Impaired Macrophage Migration Inhibitory Factor–AMP-Activated Protein Kinase Activation and Ischemic Recovery in the Senescent Heart , 2010, Circulation.

[16]  R. Damico,et al.  p53 mediates cigarette smoke-induced apoptosis of pulmonary endothelial cells: inhibitory effects of macrophage migration inhibitor factor. , 2010, American journal of respiratory cell and molecular biology.

[17]  K. Kostikas,et al.  Association of TLR4-T399I Polymorphism with Chronic Obstructive Pulmonary Disease in Smokers , 2010, Clinical & developmental immunology.

[18]  Matthias Ochs,et al.  Assessment of air space size characteristics by intercept (chord) measurement: an accurate and efficient stereological approach. , 2010, Journal of applied physiology.

[19]  T. Tsuji,et al.  Alveolar Cell Senescence Exacerbates Pulmonary Inflammation in Patients with Chronic Obstructive Pulmonary Disease , 2009, Respiration.

[20]  K. Aoshiba,et al.  Senescence hypothesis for the pathogenetic mechanism of chronic obstructive pulmonary disease. , 2009, Proceedings of the American Thoracic Society.

[21]  Junko Oshima,et al.  Cigarette smoke induces cellular senescence via Werner's syndrome protein down-regulation. , 2009, American journal of respiratory and critical care medicine.

[22]  W. Mitzner Use of mean airspace chord length to assess emphysema. , 2008, Journal of applied physiology.

[23]  C. D. Dela Cruz,et al.  Cigarette smoke selectively enhances viral PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice. , 2008, The Journal of clinical investigation.

[24]  Jiyang Cai,et al.  Essential roles of the PI3 kinase/Akt pathway in regulating Nrf2-dependent antioxidant functions in the RPE. , 2008, Investigative ophthalmology & visual science.

[25]  F. Martinez,et al.  Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. , 2007, American journal of respiratory and critical care medicine.

[26]  E. Dahl,et al.  Macrophage migration inhibitory factor (MIF) promotes cell survival by activation of the Akt pathway and role for CSN5/JAB1 in the control of autocrine MIF activity , 2007, Oncogene.

[27]  M. Blasco,et al.  Cellular Senescence in Cancer and Aging , 2007, Cell.

[28]  G. Fingerle-Rowson,et al.  MIF coordinates the cell cycle with DNA damage checkpoints. Lessons from knockout mouse models , 2007, Cell Division.

[29]  Lewis C. Cantley,et al.  AKT/PKB Signaling: Navigating Downstream , 2007, Cell.

[30]  I. Douglas,et al.  Cell death, remodeling, and repair in chronic obstructive pulmonary disease? , 2006, Proceedings of the American Thoracic Society.

[31]  Patty J. Lee,et al.  Toll-like receptor 4 deficiency causes pulmonary emphysema. , 2006, The Journal of clinical investigation.

[32]  J Vestbo,et al.  Developing COPD: a 25 year follow up study of the general population , 2006, Thorax.

[33]  T. Tsuji,et al.  Alveolar cell senescence in patients with pulmonary emphysema. , 2006, American journal of respiratory and critical care medicine.

[34]  L. Leng,et al.  CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. , 2006, Immunity.

[35]  W. Arap,et al.  State of the art. Cellular and molecular mechanisms of alveolar destruction in emphysema: an evolutionary perspective. , 2006, Proceedings of the American Thoracic Society.

[36]  R. Medzhitov,et al.  Inducible Activation of TLR4 Confers Resistance to Hyperoxia-Induced Pulmonary Apoptosis , 2006, The Journal of Immunology.

[37]  Patty J. Lee,et al.  Comment on “CD226 Is Specifically Expressed on the Surface of Th1 Cells and Regulates Their Expansion and Effector Functions” , 2006, The Journal of Immunology.

[38]  R. Bucala,et al.  Macrophage migration inhibitory factor: a critical component of autoimmune inflammatory diseases. , 2005, Drug news & perspectives.

[39]  J. Bernhagen,et al.  Link between macrophage migration inhibitory factor and cellular redox regulation. , 2005, Antioxidants & redox signaling.

[40]  R. Flavell,et al.  Role of Cathepsin S-Dependent Epithelial Cell Apoptosis in IFN-γ-Induced Alveolar Remodeling and Pulmonary Emphysema1 , 2005, The Journal of Immunology.

[41]  S. Hodge,et al.  Increased airway epithelial and T-cell apoptosis in COPD remains despite smoking cessation , 2005, European Respiratory Journal.

[42]  B. Beghé,et al.  Marked alveolar apoptosis/proliferation imbalance in end-stage emphysema , 2005, Respiratory research.

[43]  N. Sharpless,et al.  Ink4a/Arf expression is a biomarker of aging. , 2004, The Journal of clinical investigation.

[44]  P. Thompson COPD , 2004 .

[45]  W. MacNee,et al.  Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper , 2004, European Respiratory Journal.

[46]  K. Aoshiba,et al.  Increased levels of cell death and proliferation in alveolar wall cells in patients with pulmonary emphysema. , 2004, Chest.

[47]  N. Hay,et al.  Akt Inhibits Apoptosis Downstream of BID Cleavage via a Glucose-Dependent Mechanism Involving Mitochondrial Hexokinases , 2004, Molecular and Cellular Biology.

[48]  T. Calandra,et al.  Macrophage migration inhibitory factor: a regulator of innate immunity , 2003, Nature Reviews Immunology.

[49]  O. Petrenko,et al.  The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[50]  L. Leng,et al.  MIF Signal Transduction Initiated by Binding to CD74 , 2003, The Journal of experimental medicine.

[51]  T. Calandra,et al.  Macrophage migration inhibitory factor (MIF) regulates host responses to endotoxin through modulation of Toll-like receptor 4 (TLR4) , 2003, Journal of endotoxin research.

[52]  J. Bernhagen,et al.  The Cytokine Macrophage Migration Inhibitory Factor Reduces Pro-Oxidative Stress-Induced Apoptosis1 , 2003, The Journal of Immunology.

[53]  W. MacNee,et al.  4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease. , 2002, American journal of respiratory and critical care medicine.

[54]  P. Gregersen,et al.  A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis , 2002, Genes and Immunity.

[55]  John David,et al.  Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: Regulatory role in the innate immune response , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[56]  M. Cosio,et al.  Lymphocyte population and apoptosis in the lungs of smokers and their relation to emphysema. , 2001, The European respiratory journal.

[57]  D A Lynch,et al.  Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema. , 2001, American journal of respiratory and critical care medicine.

[58]  B. Ma,et al.  Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. , 2000, The Journal of clinical investigation.

[59]  M. Gaxiola,et al.  Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD. , 2000, Chest.

[60]  P. Paré,et al.  A quantification of the lung surface area in emphysema using computed tomography. , 1999, American journal of respiratory and critical care medicine.

[61]  A. Satoskar,et al.  Targeted Disruption of Migration Inhibitory Factor Gene Reveals Its Critical Role in Sepsis , 1999, The Journal of experimental medicine.

[62]  S. Shapiro,et al.  Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. , 1997, Science.

[63]  J. Bernhagen,et al.  MIF as a glucocorticoid-induced modulator of cytokine production , 1995, Nature.

[64]  A. Halbower,et al.  Agarose infiltration improves morphology of cryostat sections of lung. , 1994, Laboratory investigation; a journal of technical methods and pathology.

[65]  J. Bloom,et al.  The course and prognosis of different forms of chronic airways obstruction in a sample from the general population. , 1987, The New England journal of medicine.

[66]  R. Peto,et al.  The natural history of chronic airflow obstruction. , 1977, British medical journal.

[67]  R. Doll,et al.  Mortality in relation to smoking: 20 years' observations on male British doctors. , 1976, British medical journal.

[68]  J. Maurer Prevalence, Incidence, and Lifetime Risk for the Development of COPD in the Elderly: The Rotterdam Study , 2010 .

[69]  Matthias Ochs,et al.  How much is there really? Why stereology is essential in lung morphometry. , 2007, Journal of applied physiology.