Insulin and the insulin receptor in experimental models of learning and memory.

[1]  Sanjay Asthana,et al.  Insulin dose–response effects on memory and plasma amyloid precursor protein in Alzheimer’s disease: interactions with apolipoprotein E genotype , 2003, Psychoneuroendocrinology.

[2]  Debashis Ghosh,et al.  Impact of diabetes on cognitive function among older Latinos: a population-based cohort study. , 2003, Journal of clinical epidemiology.

[3]  M. Quon,et al.  Molecular and physiologic actions of insulin related to production of nitric oxide in vascular endothelium , 2003, Current Diabetes Reports.

[4]  Roberto Malinow,et al.  AMPA receptor trafficking and long-term potentiation. , 2003, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[5]  D. Shucard,et al.  Single-trial latency variability of auditory evoked potentials may indicate immediate memory in the albino rat. , 2003, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[6]  H. Haas,et al.  Cortico-striatal synaptic plasticity in endothelial nitric oxide synthase deficient mice , 2003, Brain Research.

[7]  Zhen Yan,et al.  Muscarinic Potentiation of GABAA Receptor Currents Is Gated by Insulin Signaling in the Prefrontal Cortex , 2003, The Journal of Neuroscience.

[8]  K. Gerozissis Brain Insulin: Regulation, Mechanisms of Action and Functions , 2003, Cellular and Molecular Neurobiology.

[9]  I. Deary,et al.  Short-term, delayed, and working memory are impaired during hypoglycemia in individuals with type 1 diabetes. , 2003, Diabetes care.

[10]  W. Jagust,et al.  Prevalence of Dementia in Older Latinos: The Influence of Type 2 Diabetes Mellitus, Stroke and Genetic Factors , 2003, Journal of the American Geriatrics Society.

[11]  P. E. Gold,et al.  Food for thought: fluctuations in brain extracellular glucose provide insight into the mechanisms of memory modulation. , 2002, Behavioral and cognitive neuroscience reviews.

[12]  L. Rossetti,et al.  Hypothalamic insulin signaling is required for inhibition of glucose production , 2002, Nature Medicine.

[13]  L. Pénicaud,et al.  Expression of insulin-responsive glucose transporter GLUT4 mRNA in the rat brain and spinal cord: An in situ hybridization study , 2002, Journal of Chemical Neuroanatomy.

[14]  Graham L. Collingridge,et al.  Phosphatidylinositol 3 kinase regulates synapse specificity of hippocampal long-term depression , 2002, Nature Neuroscience.

[15]  J. D. McGaugh Memory consolidation and the amygdala: a systems perspective , 2002, Trends in Neurosciences.

[16]  Hui Chen,et al.  Insulin receptor substrate-1 and phosphoinositide-dependent kinase-1 are required for insulin-stimulated production of nitric oxide in endothelial cells. , 2002, Molecular endocrinology.

[17]  G. Chapouthier,et al.  GABA-A Receptor Complex and Memory Processes , 2002 .

[18]  Jan Born,et al.  Sniffing neuropeptides: a transnasal approach to the human brain , 2002, Nature Neuroscience.

[19]  Zhaohui Feng,et al.  Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats , 2002, Nature Neuroscience.

[20]  M. Quirk,et al.  Requirement for Hippocampal CA3 NMDA Receptors in Associative Memory Recall , 2002, Science.

[21]  F. Bloom,et al.  Phosphatidylinositol 3-Kinase Is Required for the Expression But Not for the Induction or the Maintenance of Long-Term Potentiation in the Hippocampal CA1 Region , 2002, The Journal of Neuroscience.

[22]  S. Hoyer,et al.  The brain insulin signal transduction system and sporadic (type II) Alzheimer disease: an update , 2002, Journal of Neural Transmission.

[23]  I. Izquierdo,et al.  LY294002, an inhibitor of phosphoinositide 3-kinase given into rat hippocampus impairs acquisition, consolidation and retrieval of memory for one-trial step-down inhibitory avoidance , 2001, Behavioural pharmacology.

[24]  S. Rumpel,et al.  Insulin promotes functional induction of silent synapses in differentiating rat neocortical neurons , 2001, The European journal of neuroscience.

[25]  I. Deary,et al.  Cognitive function and information processing in Type 2 diabetes , 2001, Diabetic medicine : a journal of the British Diabetic Association.

[26]  J. Born,et al.  Improving Influence of Insulin on Cognitive Functions in Humans , 2001, Neuroendocrinology.

[27]  G. Biessels,et al.  Learning and memory in streptozotocin-induced diabetic rats in a novel spatial/object discrimination task , 2001, Behavioural Brain Research.

[28]  P. Gean,et al.  A Role for the PI-3 Kinase Signaling Pathway in Fear Conditioning and Synaptic Plasticity in the Amygdala , 2001, Neuron.

[29]  M. Quon,et al.  Insulin-stimulated Activation of eNOS Is Independent of Ca2+ but Requires Phosphorylation by Akt at Ser1179 * , 2001, The Journal of Biological Chemistry.

[30]  H. Sekihara,et al.  Postural sway and diabetic peripheral neuropathy. , 2001, Diabetes research and clinical practice.

[31]  R. Duelli,et al.  Brain glucose transporters: relationship to local energy demand. , 2001, News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society.

[32]  M. Bennett,et al.  Insulin promotes rapid delivery of N-methyl-d- aspartate receptors to the cell surface by exocytosis , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[33]  Guosong Liu,et al.  A Developmental Switch in Neurotransmitter Flux Enhances Synaptic Efficacy by Affecting AMPA Receptor Activation , 2001, Neuron.

[34]  Hillel Pratt,et al.  The mode of short-term memory encoding as indicated by event-related potentials in a memory scanning task with distractions , 2001, Clinical Neurophysiology.

[35]  J. Born,et al.  Manipulating neuropeptidergic pathways in humans: a novel approach to neuropharmacology? , 2000, European journal of pharmacology.

[36]  Rüdiger Klein,et al.  Role of Brain Insulin Receptor in Control of Body Weight and Reproduction , 2000 .

[37]  K. Sugimoto,et al.  Insulin receptor in rat peripheral nerve: its localization and alternatively spliced isoforms , 2000, Diabetes/metabolism research and reviews.

[38]  C. Ryan,et al.  Why is learning and memory dysfunction in Type 2 diabetes limited to older adults? , 2000, Diabetes/metabolism research and reviews.

[39]  S. Vannucci,et al.  Prenatal Expression of the GLUT4 Glucose Transporter in the Mouse , 2000, Developmental Neuroscience.

[40]  W. Scherbaum,et al.  Classically conditioned responses following repeated insulin and glucose administration in humans , 2000, Behavioural Brain Research.

[41]  Roberto Malinow,et al.  LTP mechanisms: from silence to four-lane traffic , 2000, Current Opinion in Neurobiology.

[42]  M. Quon,et al.  Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells. , 2000, Circulation.

[43]  R. Martins,et al.  Insulin Effects on Glucose Metabolism, Memory, and Plasma Amyloid Precursor Protein in Alzheimer's Disease Differ According to Apolipoprotein‐E Genotype , 2000, Annals of the New York Academy of Sciences.

[44]  M. Lynch,et al.  Long-term potentiation in dentate gyrus of the rat is inhibited by the phosphoinositide 3–kinase inhibitor, wortmannin , 2000, Neuropharmacology.

[45]  Yu Tian Wang,et al.  Regulation of AMPA Receptor–Mediated Synaptic Transmission by Clathrin-Dependent Receptor Internalization , 2000, Neuron.

[46]  J. Lachuer,et al.  Effects of gestational hypoxia on mRNA levels of Glut3 and Glut4 transporters, hypoxia inducible factor-1 and thyroid hormone receptors in developing rat brain , 2000, Brain Research.

[47]  A. Zaia,et al.  Insulin receptors in the brain cortex of aging mice , 2000, Mechanisms of Ageing and Development.

[48]  M. Wilson,et al.  Formation of Temporal Memory Requires NMDA Receptors within CA1 Pyramidal Neurons , 2000, Neuron.

[49]  S. Woods,et al.  Intracerebroventricular insulin enhances memory in a passive-avoidance task , 2000, Physiology & Behavior.

[50]  D. Alkon,et al.  Brain Insulin Receptors and Spatial Memory , 1999, The Journal of Biological Chemistry.

[51]  J. Newcomer,et al.  Enhancement of memory in Alzheimer disease with insulin and somatostatin, but not glucose. , 1999, Archives of general psychiatry.

[52]  S. Hoyer,et al.  Inhibition of the Neuronal Insulin Receptor Causes Alzheimer‐like Disturbances in Oxidative/Energy Brain Metabolism and in Behavior in Adult Rats , 1999, Annals of the New York Academy of Sciences.

[53]  G. Liao,et al.  Insulin Modulation of Cloned Mouse NMDA Receptor Currents in Xenopus Oocytes , 1999, Journal of neurochemistry.

[54]  O B Paulson,et al.  No effect of insulin on glucose blood-brain barrier transport and cerebral metabolism in humans. , 1999, Diabetes.

[55]  N. Rickard,et al.  Inhibition of the endothelial isoform of nitric oxide synthase impairs long-term memory formation in the chick. , 1999, Learning & memory.

[56]  G. Biessels,et al.  Hippocampal synaptic plasticity in streptozotocin-diabetic rats: impairment of long-term potentiation and facilitation of long-term depression , 1999, Neuroscience.

[57]  D. Monaghan,et al.  Insulin Causes a Transient Tyrosine Phosphorylation of NR2A and NR2B NMDA Receptor Subunits in Rat Hippocampus , 1999, Journal of neurochemistry.

[58]  J. Born,et al.  Central nervous system effects of intranasally administered insulin during euglycemia in men. , 1999, Diabetes.

[59]  G. Paludetti,et al.  The use of dynamic posturography to detect neurosensorial disorder in IDDM without clinical neuropathy. , 1999, Journal of diabetes and its complications.

[60]  S. Vannucci,et al.  Blood—Brain Barrier Glucose Transporter , 1999, Journal of neurochemistry.

[61]  T. Issad,et al.  Molecular basis of insulin action. , 1998, Diabetes & metabolism.

[62]  G. Biessels,et al.  Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: effects of insulin treatment , 1998, Brain Research.

[63]  O. Paulsen,et al.  A model of hippocampal memory encoding and retrieval: GABAergic control of synaptic plasticity , 1998, Trends in Neurosciences.

[64]  S. Vannucci,et al.  GLUT4 glucose transporter expression in rodent brain: effect of diabetes , 1998, Brain Research.

[65]  W. Banks,et al.  Differential Permeability of the Blood–Brain Barrier to Two Pancreatic Peptides: Insulin and Amylin , 1998, Peptides.

[66]  Jeff G Blanchard,et al.  Effect of Combinations of Insulin, Glucose and Scopolamine on Radial Arm Maze Performance , 1997, Pharmacology Biochemistry and Behavior.

[67]  C. Ackerley,et al.  Recruitment of functional GABAA receptors to postsynaptic domains by insulin , 1997, Nature.

[68]  G. Superti-Furga,et al.  Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor–MAP kinase–fos signalling pathway , 1997, The EMBO journal.

[69]  E. Kandel,et al.  Nitric Oxide Acts Directly in the Presynaptic Neuron to Produce Long-Term Potentiationin Cultured Hippocampal Neurons , 1996, Cell.

[70]  R. Malinow,et al.  Maturation of a Central Glutamatergic Synapse , 1996, Science.

[71]  G. Biessels,et al.  Place Learning and Hippocampal Synaptic Plasticity in Streptozotocin-Induced Diabetic Rats , 1996, Diabetes.

[72]  M. Quon,et al.  Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells. , 1996, The Journal of clinical investigation.

[73]  M. Morimatsu,et al.  Expression and localization of insulin-regulatable glucose transporter (GLUT4) in rat brain , 1996, Neuroscience Letters.

[74]  Shu-Jen Chen,et al.  Protein Tyrosine Kinase‐Mediated Potentiation of Currents from Cloned NMDA Receptors , 1996, Journal of neurochemistry.

[75]  C. Baratti,et al.  Effects of Posttraining Administration of Glucose on Retention of a Habituation Response in Mice: Participation of a Central Cholinergic Mechanism , 1996, Neurobiology of Learning and Memory.

[76]  C. Baratti,et al.  Memory Modulation by Post-training Glucose or Insulin Remains Evident at Long Retention Intervals , 1996, Neurobiology of Learning and Memory.

[77]  Richard W. Bohannon,et al.  Balance deficits accompanying renal disease are related to diabetic status. , 1995, Perceptual and motor skills.

[78]  D. Monaghan,et al.  Insulin potentiates N-methyl-d-aspartate receptor activity in Xenopus oocytes and rat hippocampus , 1995, Neuroscience Letters.

[79]  C. Baratti,et al.  The Impairment of Retention Induced by Insulin in Mice May Be Mediated by a Reduction in Central Cholinergic Activity , 1995, Neurobiology of Learning and Memory.

[80]  E. Renard,et al.  Insulin receptor substrate-1 (IRS-1) distribution in the rat central nervous system , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[81]  E R Kandel,et al.  Endothelial NOS and the blockade of LTP by NOS inhibitors in mice lacking neuronal NOS. , 1994, Science.

[82]  J. Olefsky,et al.  Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor. , 1994, The Journal of biological chemistry.

[83]  P. Trayhurn,et al.  Glucose transporters (GLUTs 1-4) and their mRNAs in regions of the rat brain: insulin-sensitive transporter expression in the cerebellum. , 1994, Canadian journal of physiology and pharmacology.

[84]  C. Kahn,et al.  The insulin signaling system. , 1994, The Journal of biological chemistry.

[85]  C. Ryan,et al.  Effects of insulin-dependent diabetes on learning and memory efficiency in adults. , 1993, Journal of clinical and experimental neuropsychology.

[86]  C. Roberts,et al.  Insulin and Insulin‐like Growth Factor‐I Induced Phosphorylation in Neurally Derived Cells , 1993, Annals of the New York Academy of Sciences.

[87]  E. Kandel,et al.  Nitric oxide and carbon monoxide produce activity-dependent long-term synaptic enhancement in hippocampus. , 1993, Science.

[88]  M. Raizada,et al.  The cellular and physiological actions of insulin in the central nervous system , 1993, Neurochemistry International.

[89]  A. L. Dudley,et al.  Heterogeneity of Messenger RNA That Encodes the Rat Insulin Receptor Is Limited to the Domain of Exon 11: Analysis by RNA Heteroduplex Mapping, Amplification of cDNA, and In Vitro Translation , 1992, Diabetes.

[90]  T. Pawson,et al.  A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction , 1992, Cell.

[91]  D. Ingram,et al.  Complex maze performance in young and aged rats: Response to glucose treatment and relationship to blood insulin and glucose , 1992, Physiology & Behavior.

[92]  J. Livingston,et al.  Insulin receptors in the central nervous system: Localization, signalling mechanisms and functional aspects , 1991, Progress in Neurobiology.

[93]  J. Olefsky The Insulin Receptor: A Multifunctional Protein , 1990, Diabetes.

[94]  H. Werner,et al.  Regulation of rat brain/HepG2 glucose transporter gene expression by insulin and insulin-like growth factor-I in primary cultures of neuronal and glial cells. , 1989, Endocrinology.

[95]  I. Whishaw,et al.  Postischemic insulin reduces spatial learning deficit following transient forebrain ischemia in rats. , 1989, Stroke.

[96]  K. Perryman,et al.  Cortical function in elderly non-insulin dependent diabetic patients. Behavioral and electrophysiologic studies. , 1988, Archives of internal medicine.

[97]  J. Pessin,et al.  Glucose-dependent regulation of glucose transport activity, protein, and mRNA in primary cultures of rat brain glial cells. , 1988, The Journal of biological chemistry.

[98]  S. Amir,et al.  Centrally mediated hypoglycemic effect of insulin: apparent involvement of specific insulin receptors , 1987, Brain Research.

[99]  D. Singer,et al.  Decreased cognitive function in aging non-insulin-dependent diabetic patients. , 1984, The American journal of medicine.

[100]  E. Hooghe-Peters,et al.  Glucose metabolism in murine fetal cortical brain cells: Lack of insulin effects , 1984, Journal of cellular physiology.

[101]  S. Gammeltoft,et al.  Insulin receptors in rat brain cortex. Kinetic evidence for a receptor subtype in the central nervous system , 1984, Peptides.

[102]  R. Morris Developments of a water-maze procedure for studying spatial learning in the rat , 1984, Journal of Neuroscience Methods.

[103]  M. Raizada,et al.  Effects of insulin and tunicamycin on neuronal insulin receptors in culture. , 1983, The American journal of physiology.

[104]  K. Heidenreich,et al.  Structural differences between insulin receptors in the brain and peripheral target tissues. , 1983, The Journal of biological chemistry.

[105]  O. Paulson,et al.  Insulin increases glucose transfer across the blood-brain barrier in man. , 1981, The Journal of clinical investigation.

[106]  C. J. Goodner,et al.  Investigation of the effect of insulin upon regional brain glucose metabolism in the rat in vivo. , 1980, Endocrinology.

[107]  F. Huppert,et al.  Normal and Abnormal Forgetting in Organic Amnesia: Effect of Locus of Lesion , 1979, Cortex.

[108]  J. A. Horel,et al.  THE NEUROANATOMY OF AMNESIA , 1978 .

[109]  M. Folstein,et al.  Defective long-term caloric regulation in obesity. , 1978, NIDA research monograph.

[110]  J. D. Castro,et al.  Insulin pretreatment facilitates recovery after dorsal hippocampal lesions , 1976, Physiology & Behavior.

[111]  S. Woods,et al.  Effect of Cerebral Intraventricular Insulin on Pancreatic Insulin Secretion in the Dog , 1975, Diabetes.

[112]  S. Woods Conditioned hypoglycemia: effect of vagotomy and pharmacological blockade. , 1972, The American journal of physiology.

[113]  W. Makous,et al.  A new technique for conditioned hypoglycemia , 1968 .

[114]  S. Lavy,et al.  Effect of insulin administered intracisternally on the glucose level of the blood and the cerebrospinal fluid in vagotomized dogs. , 1966, Experimental neurology.

[115]  S. Craft,et al.  The Role of Insulin Resistance in the Pathogenesis of Alzheimer’s Disease , 2003, CNS drugs.

[116]  F. Kaufman,et al.  Neurocognitive functioning in children diagnosed with diabetes before age 10 years. , 1999, Journal of diabetes and its complications.

[117]  L. Pelosi,et al.  Effects of age on working memory: an event-related potential study. , 1999, Brain research. Cognitive brain research.

[118]  S. Hoyer,et al.  Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis , 1998, Journal of Neural Transmission.

[119]  K. Jellinger,et al.  Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease , 1998, Journal of Neural Transmission.

[120]  P. Tun,et al.  Age and diabetes related changes in verbal fluency. , 1987, Experimental aging research.

[121]  G. Paxinos,et al.  The Rat Brain in Stereotaxic Coordinates , 1983 .

[122]  S. Woods,et al.  Conditioned insulin secretion and hypoglycemia following repeated injections of tolbutamide in rats. , 1972, Endocrinology.