Effects of Physical Activity on Liver Function in Patients with Non-alcoholic Fatty Liver Disease: A Meta-Analysis

However, most of the drugs administered for NAFLD, such as the cholesterol-lowering drugs, statins, and antioxidants, hepatoprotective drugs and insulin-sensitizing agents, have pharmacological toxicity resulting in side effects. In recent years, Oza, et al. [7], concluded that lifestyle changes including moderate aerobic exercise has significance in the improvement and rehabilitation of patients. Researchers worldwide have conducted a number of studies on the effects of exercise; however, large-scale trials have not been carried out due to limitations on the prevalence of NAFLD [8-11]. Therefore, in the present study we performed a meta-analysis of Randomized Controlled Trials (RCTs) to evaluate the effects of physical exercise in patients with NAFLD.

[1]  Wuyuan Lu,et al.  Mitochondrial dysfunction in obesity-associated nonalcoholic fatty liver disease: the protective effects of pomegranate with its active component punicalagin. , 2014, Antioxidants & redox signaling.

[2]  G. Calamita,et al.  Reduced hepatic aquaporin-9 and glycerol permeability are related to insulin resistance in non-alcoholic fatty liver disease , 2014, International Journal of Obesity.

[3]  G. Farrell,et al.  Coffee and non‐alcoholic fatty liver disease: Brewing evidence for hepatoprotection? , 2014, Journal of gastroenterology and hepatology.

[4]  Jun Zou,et al.  Effect of aerobic exercise and low carbohydrate diet on pre-diabetic non-alcoholic fatty liver disease in postmenopausal women and middle aged men – the role of gut microbiota composition: study protocol for the AELC randomized controlled trial , 2014, BMC Public Health.

[5]  Daniel Jackson,et al.  A refined method for multivariate meta-analysis and meta-regression , 2013, Statistics in medicine.

[6]  R. Malekzadeh,et al.  Statins for non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. , 2013, The Cochrane database of systematic reviews.

[7]  H. Cao,et al.  Role of diet and nutritional management in non‐alcoholic fatty liver disease , 2013, Journal of gastroenterology and hepatology.

[8]  Shaodong Chen,et al.  Decoction vs extracts-mixed solution: effect of yiqihuoxue formula on non-alcoholic fatty liver disease in rats. , 2013, Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.

[9]  A. Maruani,et al.  Les recommandations CONSORT (CONsolidated Standards Of Reporting Trials) , 2013 .

[10]  T. Hoffmann,et al.  Inhibition of Glutaminyl Cyclases alleviates CCL2‐mediated inflammation of non‐alcoholic fatty liver disease in mice , 2013, International journal of experimental pathology.

[11]  Christopher D. Williams,et al.  Prospective histopathologic evaluation of lifestyle modification in nonalcoholic fatty liver disease: a randomized trial , 2013, Therapeutic advances in gastroenterology.

[12]  大座 紀子.  A pilot trial of body weight reduction for nonalcoholic fatty liver disease with a home-based lifestyle modification intervention delivered in collaboration with interdisciplinary medical staff , 2013 .

[13]  A. Maruani,et al.  [The CONSORT statement (CONsolidated Standards Of Reporting Trials)]. , 2013, Annales de dermatologie et de venereologie.

[14]  A. Alisi,et al.  Transient elastography and serum biomarkers: two-step screening methods for liver fibrosis in non-alcoholic fatty liver disease before liver biopsy. , 2012, Expert opinion on medical diagnostics.

[15]  S. Klein,et al.  Randomized trial of exercise effect on intrahepatic triglyceride content and lipid kinetics in nonalcoholic fatty liver disease , 2012, Hepatology.

[16]  Michael Charlton,et al.  The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. , 2012, Gastroenterology.

[17]  D. Drożdż,et al.  A decrease in fasting FGF19 levels is associated with the development of non-alcoholic fatty liver disease in obese adolescents , 2012, Journal of pediatric endocrinology & metabolism : JPEM.

[18]  A Study of Carotid Atherosclerosis in Patients with Non-alcoholic Fatty Liver Disease , 2012, Indian Journal of Clinical Biochemistry.

[19]  Sarah A. Moore,et al.  Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss , 2011, Gut.

[20]  V. Wong,et al.  Should all patients with nonalcoholic fatty liver disease undergo oral glucose tolerance test? , 2011, Journal of gastroenterology and hepatology.

[21]  R. Malekzadeh,et al.  Statins for non‐alcoholic steatohepatitis , 2010 .

[22]  K. Qureshi,et al.  Comparative Evaluation of Whole Body and Hepatic Insulin Resistance Using Indices from Oral Glucose Tolerance Test in Morbidly Obese Subjects with Nonalcoholic Fatty Liver Disease , 2010, Journal of obesity.

[23]  J Bernadette Moore,et al.  Non-alcoholic fatty liver disease: the hepatic consequence of obesity and the metabolic syndrome , 2010, Proceedings of the Nutrition Society.

[24]  E. Jackvony,et al.  Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis , 2010, Hepatology.

[25]  D. Moher,et al.  Reprint--preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. , 2009, Physical therapy.

[26]  S. Solomon,et al.  Nonalcoholic Fatty Liver Disease and Metabolic Syndrome in Hypopituitary Patients , 2009, The American journal of the medical sciences.

[27]  A. Bauman,et al.  Independent effects of physical activity in patients with nonalcoholic fatty liver disease , 2009, Hepatology.

[28]  Jeanne M Clark,et al.  The epidemiology of nonalcoholic fatty liver disease: a global perspective. , 2008, Seminars in liver disease.

[29]  Jun-Fen Fu,et al.  Effect of lifestyle intervention on non-alcoholic fatty liver disease in Chinese obese children. , 2008, World journal of gastroenterology.

[30]  C. Day,et al.  Benefits of lifestyle modification in NAFLD , 2007, Gut.

[31]  H. Fukui,et al.  Mitochondrial abnormality and oxidative stress in nonalcoholic steatohepatitis. , 2007, Alcoholism, clinical and experimental research.

[32]  A. Suzuki,et al.  Effect of changes on body weight and lifestyle in nonalcoholic fatty liver disease. , 2005, Journal of hepatology.

[33]  C. Zou,et al.  Serum adiponectin, resistin levels and non-alcoholic fatty liver disease in obese children. , 2005, Endocrine journal.

[34]  C. Ahn,et al.  Metabolic significance of nonalcoholic fatty liver disease in nonobese, nondiabetic adults. , 2004, Archives of internal medicine.

[35]  Z. Younossi,et al.  Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. , 1999, Gastroenterology.

[36]  D L Rothman,et al.  Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. , 1996, The New England journal of medicine.