Copper-catalyzed direct trifluoromethylation of propiolates: construction of trifluoromethylated coumarins.

A novel copper-catalyzed direct trifluoromethylation of internal alkynes was developed, obtaining a series of trifluoromethylated coumarins in good yields. The cyclization was proposed to proceed via a radical mechanism under copper-catalyzed conditions with good functional group tolerance.

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