Recent advances in microfluidic technologies for organ-on-a-chip

[1]  G. Whitesides.  The origins and the future of microfluidics , 2006, Nature.

[2]  Sindy K. Y. Tang,et al.  Paper-supported 3D cell culture for tissue-based bioassays , 2009, Proceedings of the National Academy of Sciences.

[3]  L. Niklason,et al.  Scaffold-free vascular tissue engineering using bioprinting. , 2009, Biomaterials.

[4]  R. Zengerle,et al.  Microfluidic lab-on-a-chip platforms: requirements, characteristics and applications. , 2010, Chemical Society reviews.

[5]  D. Ingber,et al.  Reconstituting Organ-Level Lung Functions on a Chip , 2010, Science.

[6]  Ali Khademhosseini,et al.  Digitally tunable physicochemical coding of material composition and topography in continuous microfibres. , 2011, Nature materials.

[7]  Chien-Chung Peng,et al.  Generation of oxygen gradients in microfluidic devices for cell culture using spatially confined chemical reactions. , 2011, Lab on a chip.

[8]  Donald E Ingber,et al.  Microengineered physiological biomimicry: organs-on-chips. , 2012, Lab on a chip.

[9]  R. Kamm,et al.  Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function , 2012, Proceedings of the National Academy of Sciences.

[10]  Ali Khademhosseini,et al.  Biomimetic tissues on a chip for drug discovery. , 2012, Drug discovery today.

[11]  Rui Liu,et al.  Spatiotemporally controlled and multifactor involved assay of neuronal compartment regeneration after chemical injury in an integrated microfluidics. , 2012, Analytical chemistry.

[12]  Hanseup Kim,et al.  Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB). , 2012, Lab on a chip.

[13]  T. Huang,et al.  Accelerating drug discovery via organs-on-chips. , 2013, Lab on a chip.

[14]  Wenming Liu,et al.  Investigation of hypoxia-induced myocardial injury dynamics in a tissue interface mimicking microfluidic device. , 2013, Analytical chemistry.

[15]  F. Sonntag,et al.  A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture. , 2013, Lab on a chip.

[16]  M. Gijs,et al.  Exploring living multicellular organisms, organs, and tissues using microfluidic systems. , 2013, Chemical reviews.

[17]  Pamela Habibovic,et al.  Regeneration-on-a-chip? The perspectives on use of microfluidics in regenerative medicine. , 2013, Lab on a chip.

[18]  Cheng-Hsien Liu,et al.  Liver-cell patterning lab chip: mimicking the morphology of liver lobule tissue. , 2013, Lab on a chip.

[19]  Shoji Takeuchi,et al.  Metre-long cell-laden microfibres exhibit tissue morphologies and functions. , 2013, Nature materials.

[20]  D. Ingber,et al.  Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment. , 2013, Integrative biology : quantitative biosciences from nano to macro.

[21]  D. Beebe,et al.  The present and future role of microfluidics in biomedical research , 2014, Nature.

[22]  J. Lewis,et al.  3D Bioprinting of Vascularized, Heterogeneous Cell‐Laden Tissue Constructs , 2014, Advanced materials.

[23]  Sang-Hoon Lee,et al.  Microfluidic spinning of micro- and nano-scale fibers for tissue engineering. , 2014, Lab on a chip.

[24]  Savas Tasoglu,et al.  Microscale Assembly Directed by Liquid‐Based Template , 2014, Advanced materials.

[25]  Andreas Hierlemann,et al.  Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis , 2014, Nature Communications.

[26]  Tony Jun Huang,et al.  Standing Surface Acoustic Wave Based Cell Coculture , 2014, Analytical chemistry.

[27]  Yongping Chen,et al.  Bioinspired Multicompartmental Microfibers from Microfluidics , 2014, Advanced materials.

[28]  Jinyi Wang,et al.  Mixed hydrogel bead-based tumor spheroid formation and anticancer drug testing. , 2014, The Analyst.

[29]  G. Dubini,et al.  Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation , 2014, Proceedings of the National Academy of Sciences.

[30]  F. Sonntag,et al.  A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents. , 2015, Lab on a chip.

[31]  Tianbao Li,et al.  Monitoring tumor response to anticancer drugs using stable three-dimensional culture in a recyclable microfluidic platform. , 2015, Analytical chemistry.

[32]  Hyunjae Lee,et al.  Capillarity Guided Patterning of Microliquids. , 2015, Small.

[33]  J. Collins,et al.  Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip , 2015, Proceedings of the National Academy of Sciences.

[34]  Sang-Hoon Lee,et al.  Central Nervous System and its Disease Models on a Chip. , 2015, Trends in biotechnology.

[35]  D. Huh,et al.  Organs-on-chips at the frontiers of drug discovery , 2015, Nature Reviews Drug Discovery.

[36]  G. Whitesides,et al.  A paper-based invasion assay: assessing chemotaxis of cancer cells in gradients of oxygen. , 2015, Biomaterials.

[37]  Ronan M. T. Fleming,et al.  Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices. , 2015, Biosensors & bioelectronics.

[38]  F. Camargo,et al.  Emerging evidence on the role of the Hippo/YAP pathway in liver physiology and cancer. , 2015, Journal of hepatology.

[39]  Y. Li,et al.  Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting , 2016, Proceedings of the National Academy of Sciences.

[40]  Babak Ziaie,et al.  A paper-based in vitro model for on-chip investigation of the human respiratory system. , 2016, Lab on a chip.

[41]  Zhongze Gu,et al.  Organ-on-a-Chip Systems: Microengineering to Biomimic Living Systems. , 2016, Small.

[42]  Steven C George,et al.  Engineering anastomosis between living capillary networks and endothelial cell-lined microfluidic channels. , 2016, Lab on a chip.

[43]  J. Qin,et al.  Simple Spinning of Heterogeneous Hollow Microfibers on Chip , 2016, Advanced materials.

[44]  Q. Fang,et al.  Microdroplet chain array for cell migration assays. , 2016, Lab on a chip.

[45]  Rui Zhang,et al.  Rapid formation of size-controllable multicellular spheroids via 3D acoustic tweezers. , 2016, Lab on a chip.

[46]  Samuel Parry,et al.  A microphysiological model of the human placental barrier. , 2016, Lab on a chip.

[47]  N. Annabi,et al.  Microengineered cancer-on-a-chip platforms to study the metastatic microenvironment. , 2016, Lab on a chip.

[48]  Radivoje Prodanovic,et al.  Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet. , 2016, Lab on a chip.

[49]  Michael L Shuler,et al.  Design and demonstration of a pumpless 14 compartment microphysiological system , 2016, Biotechnology and bioengineering.

[50]  J. Lewis,et al.  Printing soft matter in three dimensions , 2016, Nature.

[51]  Keekyoung Kim,et al.  3D bioprinting for engineering complex tissues. , 2016, Biotechnology advances.

[52]  Albert Folch,et al.  3D-Printed Microfluidics. , 2016, Angewandte Chemie.

[53]  Qiushui Chen,et al.  Biochemical analysis on microfluidic chips , 2016 .

[54]  A. McGuigan,et al.  Development of TRACER: tissue roll for analysis of cellular environment and response , 2016, Biofabrication.

[55]  L. Bergers,et al.  Immune-competent human skin disease models. , 2016, Drug discovery today.

[56]  Anthony Atala,et al.  Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling. , 2016, Drug discovery today.

[57]  Jinyi Wang,et al.  On-Chip Construction of Liver Lobule-like Microtissue and Its Application for Adverse Drug Reaction Assay. , 2016, Analytical chemistry.

[58]  F. Bäckhed,et al.  Signals from the gut microbiota to distant organs in physiology and disease , 2016, Nature Medicine.

[59]  Radhakrishnan Mahadevan,et al.  A 3D engineered tumour for spatial snap-shot analysis of cell metabolism and phenotype in hypoxic gradients , 2015, Nature materials.

[60]  Ning Hu,et al.  Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors , 2017, Proceedings of the National Academy of Sciences.

[61]  Jeong-Yeol Yoon,et al.  Organ-on-a-chip for assessing environmental toxicants. , 2017, Current opinion in biotechnology.

[62]  Zhongze Gu,et al.  Bioinspired Helical Microfibers from Microfluidics , 2017, Advanced materials.

[63]  Aarathi Balijepalli,et al.  Organs-on-chips: research and commercial perspectives. , 2017, Drug discovery today.

[64]  Roger D. Kamm,et al.  A 3D neurovascular microfluidic model consisting of neurons, astrocytes and cerebral endothelial cells as a blood-brain barrier. , 2017, Lab on a chip.

[65]  L A Low,et al.  Tissue chips - innovative tools for drug development and disease modeling. , 2017, Lab on a chip.

[66]  M. Radisic,et al.  Organ-on-a-chip devices advance to market. , 2017, Lab on a chip.

[67]  Yue Yu,et al.  A disease model of diabetic nephropathy in a glomerulus-on-a-chip microdevice. , 2017, Lab on a chip.

[68]  James Friend,et al.  Cell agglomeration in the wells of a 24-well plate using acoustic streaming. , 2017, Lab on a chip.

[69]  G. Luo,et al.  Bioinspired Microfibers with Embedded Perfusable Helical Channels , 2017, Advanced materials.

[70]  O. B. Usta,et al.  Generation and manipulation of hydrogel microcapsules by droplet-based microfluidics for mammalian cell culture. , 2017, Lab on a chip.

[71]  Ziyi He,et al.  Recent advances in microfluidic 3D cellular scaffolds for drug assays , 2017 .

[72]  X. Cui,et al.  Advances in multicellular spheroids formation , 2017, Journal of The Royal Society Interface.

[73]  Utkan Demirci,et al.  Bioacoustic-enabled patterning of human iPSC-derived cardiomyocytes into 3D cardiac tissue. , 2017, Biomaterials.

[74]  Richard M Maceiczyk,et al.  Microfluidic Technology: Uncovering the Mechanisms of Nanocrystal Nucleation and Growth. , 2017, Accounts of chemical research.

[75]  Meng Shi,et al.  Paper-based cell culture platform and its emerging biomedical applications , 2017 .

[76]  S. Sugiura,et al.  A multi-throughput multi-organ-on-a-chip system on a plate formatted pneumatic pressure-driven medium circulation platform. , 2017, Lab on a chip.

[77]  Uwe Marx,et al.  Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model , 2017, Scientific Reports.

[78]  Jong Hwan Sung,et al.  Organ‐on‐a‐Chip Technology for Reproducing Multiorgan Physiology , 2018, Advanced healthcare materials.

[79]  Charles S Henry,et al.  Powering ex vivo tissue models in microfluidic systems. , 2018, Lab on a chip.

[80]  A. Seyfoori,et al.  Self-filling microwell arrays (SFMAs) for tumor spheroid formation. , 2018, Lab on a chip.

[81]  C. Bouten,et al.  A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions , 2018, Lab on a chip.

[82]  Myeongwoo Kang,et al.  Microstructure guided multi-scale liquid patterning on an open surface. , 2018, Lab on a chip.

[83]  T. Gaborski,et al.  Use of porous membranes in tissue barrier and co-culture models. , 2018, Lab on a chip.

[84]  Martin Weiss,et al.  Organ‐on‐a‐Chip Systems for Women's Health Applications , 2018, Advanced healthcare materials.

[85]  Anne Riu,et al.  Investigation of the effect of hepatic metabolism on off-target cardiotoxicity in a multi-organ human-on-a-chip system. , 2018, Biomaterials.

[86]  Mahadevabharath R. Somayaji,et al.  Physiologically Based Pharmacokinetic and Pharmacodynamic Analysis Enabled by Microfluidically Linked Organs-on-Chips. , 2018, Annual review of pharmacology and toxicology.

[87]  Seung‐Woo Cho,et al.  High-resolution acoustophoretic 3D cell patterning to construct functional collateral cylindroids for ischemia therapy , 2018, Nature Communications.

[88]  Stephanie J Hachey,et al.  Applications of tumor chip technology. , 2018, Lab on a chip.

[89]  James P K Armstrong,et al.  Engineering Anisotropic Muscle Tissue using Acoustic Cell Patterning , 2018, Advanced materials.

[90]  Seiichi Ishida,et al.  Organs-on-a-chip: Current applications and consideration points for in vitro ADME-Tox studies. , 2018, Drug metabolism and pharmacokinetics.

[91]  Behnaz Heidary Araghi,et al.  Controlling Differentiation of Stem Cells for Developing Personalized Organ‐on‐Chip Platforms , 2018, Advanced healthcare materials.

[92]  M Wiklund,et al.  Acoustic formation of multicellular tumor spheroids enabling on-chip functional and structural imaging. , 2018, Lab on a chip.

[93]  E. Young,et al.  Microfluidic lung airway-on-a-chip with arrayable suspended gels for studying epithelial and smooth muscle cell interactions. , 2018, Lab on a chip.

[94]  Michael L Shuler,et al.  A pumpless body-on-a-chip model using a primary culture of human intestinal cells and a 3D culture of liver cells. , 2018, Lab on a chip.

[95]  Julia Hoeng,et al.  A lung/liver-on-a-chip platform for acute and chronic toxicity studies. , 2018, Lab on a chip.

[96]  X. Mu,et al.  Design and fabrication of a liver-on-a-chip platform for convenient, highly efficient, and safe in situ perfusion culture of 3D hepatic spheroids. , 2018, Lab on a chip.

[97]  Milica Radisic,et al.  Advances in organ-on-a-chip engineering , 2018, Nature Reviews Materials.

[98]  Daniel Irimia,et al.  Inflammation-on-a-Chip: Probing the Immune System Ex Vivo. , 2018, Trends in biotechnology.

[99]  Y. S. Zhang,et al.  Microfluidics‐Enabled Multimaterial Maskless Stereolithographic Bioprinting , 2018, Advanced materials.

[100]  Donald E. Ingber,et al.  Modelling cancer in microfluidic human organs-on-chips , 2019, Nature Reviews Cancer.

[101]  A. van den Berg,et al.  Personalised organs-on-chips: functional testing for precision medicine , 2018, Lab on a chip.

[102]  Dino Di Carlo,et al.  Nonlinear Microfluidics. , 2018, Analytical chemistry.

[103]  Jong Hwan Sung,et al.  Recent Advances in Body-on-a-Chip Systems. , 2018, Analytical chemistry.

[104]  Sarah Hedtrich,et al.  3D organ models—Revolution in pharmacological research? , 2018, Pharmacological Research.

[105]  Hanna Nykvist,et al.  Impact of macronutrients printability and 3D-printer parameters on 3D-food printing: A review. , 2019, Food chemistry.

[106]  Yi Zhao,et al.  Multi-Organs-on-Chips: Towards Long-Term Biomedical Investigations , 2019, Molecules.