Physiological role of cGMP and cGMP-dependent protein kinase in the cardiovascular system.

[1]  F. Morel,et al.  Atrial natriuretic peptide effects on cGMP and cAMP contents in microdissected glomeruli and segments of the rat and rabbit nephrons , 1987, Pflügers Archiv.

[2]  F. Hofmann,et al.  Cyclic GMP-dependent protein kinase stimulates the plasmalemmal Ca2+ pump of smooth muscle via phosphorylation of phosphatidylinositol. , 1988, The Biochemical journal.

[3]  S. Nakashima,et al.  Inhibitory action of cyclic GMP on secretion, polyphosphoinositide hydrolysis and calcium mobilization in thrombin-stimulated human platelets. , 1986, Biochemical and biophysical research communications.

[4]  L. Ignarro,et al.  Regulation of purified soluble guanylate cyclase by porphyrins and metalloporphyrins: a unifying concept. , 1984, Advances in cyclic nucleotide and protein phosphorylation research.

[5]  J. Zwiller,et al.  Protein kinase C catalyzes phosphorylation of guanylate cyclase in vitro. , 1985, The Journal of biological chemistry.

[6]  J. Exton.  Mechanisms of action of calcium‐mobilizing agonists: some variations on a young theme , 1988, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[7]  U. Kaupp,et al.  Mechanism of photoreception in vertebrate vision , 1986 .

[8]  E. Krebs,et al.  Studies on the site in the regulatory subunit of type I cAMP-dependent protein kinase phosphorylated by cGMP-dependent protein kinase. , 1981, The Journal of biological chemistry.

[9]  D. Nelson,et al.  A novel cGMP-dependent protein kinase from Paramecium. , 1988, The Journal of biological chemistry.

[10]  Y. Nozawa,et al.  Inhibition by cyclic AMP of guanine nucleotide‐induced activation of phosphoinositide‐specific phospholipase C in human platelets , 1989, FEBS letters.

[11]  V. Manganiello,et al.  Effects of atrial natriuretic factor on cyclic guanosine monophosphate and cyclic adenosine monophosphate accumulation in microdissected nephron segments from rats. , 1987, The Journal of clinical investigation.

[12]  M. Hinescu,et al.  The mechanism of cGMP-induced relaxation in vascular smooth muscle. , 1985, European journal of pharmacology.

[13]  U. Walter,et al.  Intracellular mechanism of action of vasodilators. , 1988, European heart journal.

[14]  M. Haddox,et al.  Activation of soluble splenic cell guanylate cyclase by prostaglandin endoperoxides and fatty acid hydroperoxides. , 1978, The Journal of biological chemistry.

[15]  L. Ignarro,et al.  The pharmacological and physiological role of cyclic GMP in vascular smooth muscle relaxation. , 1985, Annual review of pharmacology and toxicology.

[16]  E. Carafoli,et al.  The Ca2+-pumping ATPase and the major substrates of the cGMP-dependent protein kinase in smooth muscle sarcolemma are distinct entities. , 1988, European journal of biochemistry.

[17]  F. Murad,et al.  Sodium nitroprusside-induced protein phosphorylation in intact rat aorta is mimicked by 8-bromo cyclic GMP. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[18]  F. Hofmann,et al.  cGMP and cAMP inhibit tension development in skinned coronary arteries , 1984, Pflügers Archiv.

[19]  J. Vane,et al.  Endothelium-derived relaxing factor reduces platelet adhesion to bovine endothelial cells. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[20]  U. Walter,et al.  cGMP-dependent protein kinase is present in high concentrations in contractile cells of the kidney vasculature. , 1986, Journal of cyclic nucleotide and protein phosphorylation research.

[21]  T. Lincoln,et al.  Phosphorylation of mammalian myosin light chain kinases by the catalytic subunit of cyclic AMP-dependent protein kinase and by cyclic GMP-dependent protein kinase. , 1984, The Journal of biological chemistry.

[22]  C. Le Peuch,et al.  Regulation of calcium accumulation and efflux from platelet vesicles. Possible role for cyclic-AMP-dependent phosphorylation and calmodulin. , 1983, Biochimica et biophysica acta.

[23]  Geoffrey H. Gold,et al.  A cyclic nucleotide-gated conductance in olfactory receptor cilia , 1987, Nature.

[24]  P. Greengard,et al.  Localization in mammalian brain of G-substrate, a specific substrate for guanosine 3',5'-cyclic monophosphate-dependent protein kinase , 1984, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[25]  Beavo Ja.  Multiple isozymes of cyclic nucleotide phosphodiesterase. , 1988 .

[26]  J. Felbel,et al.  Regulation of cytosolic calcium by cAMP and cGMP in freshly isolated smooth muscle cells from bovine trachea. , 1988, The Journal of biological chemistry.

[27]  S. Holzmann.  Endothelium-induced relaxation by acetylcholine associated with larger rises in cyclic GMP in coronary arterial strips. , 1982, Journal of cyclic nucleotide research.

[28]  E. Gerber,et al.  Regulation of the intracellular calcium level in human blood platelets: cyclic adenosine 3',5'-monophosphate dependent phosphorylation of a 22,000 dalton component in isolated Ca2+-accumulating vesicles. , 1979, Biochimica et biophysica acta.

[29]  M. O’Donnell,et al.  Role of cyclic GMP in atrial natriuretic factor stimulation of Na+,K+,Cl- cotransport in vascular smooth muscle cells. , 1986, The Journal of biological chemistry.

[30]  T. Inagami,et al.  Identification and characterization of three distinct atrial natriuretic factor receptors. Evidence for tissue-specific heterogeneity of receptor subtypes in vascular smooth muscle, kidney tubular epithelium, and Leydig tumor cells by ligand binding, photoaffinity labeling, and tryptic proteolysis. , 1988, The Journal of biological chemistry.

[31]  J. Schultz,et al.  Calcium/calmodulin-regulated guanylate cyclases in the ciliary membranes from Paramecium and tetrahymena. , 1984, Advances in cyclic nucleotide and protein phosphorylation research.

[32]  E. Böhme,et al.  Guanyl cyclase. Determination of enzyme activity. , 1969, Life sciences.

[33]  C. C. Reynolds,et al.  Identification of glycoprotein Ib beta as one of the major proteins phosphorylated during exposure of intact platelets to agents that activate cyclic AMP-dependent protein kinase. , 1987, The Journal of biological chemistry.

[34]  U. Walter,et al.  Purification of a vasodilator-regulated phosphoprotein from human platelets. , 1989, European journal of biochemistry.

[35]  P. Greengard,et al.  Guanosine 3':5'-cyclic monophosphate-dependent phosphorylation of endogenous substrate proteins in membranes of mammalian smooth muscle. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[36]  L. Forte,et al.  cAMP-dependent reduction in membrane fluxes during relaxation of arterial smooth muscle. , 1984, The American journal of physiology.

[37]  E. E. Fesenko,et al.  Induction by cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segment , 1985, Nature.

[38]  F. Murad,et al.  Cyclic GMP synthesis and function. , 1987, Pharmacological reviews.

[39]  P. Greengard,et al.  A specific substrate from rabbit cerebellum for guanosine 3':5'-monophosphate-dependent protein kinase. II. Kinetic studies on its phosphorylation by guanosine 3':5'-monophosphate-dependent and adenosine 3':5'-monophosphate-dependent protein kinases. , 1981, The Journal of biological chemistry.

[40]  G. Schultz,et al.  Regulation of cyclic GMP formation by soluble guanylate cyclase: stimulation by NO-containing compounds. , 1984, Advances in cyclic nucleotide and protein phosphorylation research.

[41]  R. Furchgott,et al.  The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine , 1980, Nature.

[42]  G. Schultz,et al.  Modulations of voltage-dependent ion channels by extracellular signals , 1987 .

[43]  R. Butcher,et al.  Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. , 1962, The Journal of biological chemistry.

[44]  P. Needleman,et al.  Atriopeptin: a cardiac hormone intimately involved in fluid, electrolyte, and blood-pressure homeostasis. , 1986, The New England journal of medicine.

[45]  L. Dangott,et al.  Covalent coupling of a resact analogue to guanylate cyclase. , 1986, The Journal of biological chemistry.

[46]  R. D. Wade,et al.  Guanosine cyclic 3',5'-phosphate dependent protein kinase, a chimeric protein homologous with two separate protein families. , 1984, Biochemistry.

[47]  D. Goeddel,et al.  Membrane guanylate cyclase is a cell-surface receptor with homology to protein kinases , 1988, Nature.

[48]  F. Murad,et al.  Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine. , 1977, Journal of cyclic nucleotide research.

[49]  P. Greengard,et al.  A specific substrate from rabbit cerebellum for guanosine-3':5'-monophosphate-dependent protein kinase. III. Amino acid sequences at the two phosphorylation sites. , 1981, The Journal of biological chemistry.

[50]  U. Kaupp,et al.  Cyclic GMP directly regulates a cation conductance in membranes of bovine rods by a cooperative mechanism. , 1985, The Journal of biological chemistry.

[51]  R. Ardaillou,et al.  Stimulation of cyclic GMP synthesis in human cultured glomerular cells by atrial natriuretic peptide , 1986, FEBS letters.

[52]  R. Roskoski.  [1] Assays of protein kinase , 1983 .

[53]  L. Ignarro,et al.  Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[54]  F. Murad,et al.  Nitric oxide activates guanylate cyclase and increases guanosine 3':5'-cyclic monophosphate levels in various tissue preparations. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[55]  F. Murad,et al.  Co-purification of an atrial natriuretic factor receptor and particulate guanylate cyclase from rat lung. , 1986, The Journal of biological chemistry.

[56]  M. O’Donnell,et al.  Atrial natriuretic factor stimulates Na/K/Cl cotransport in vascular smooth muscle cells. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[57]  Takahiro Matsumoto,et al.  8‐Bromoguanosine 3′:5′‐cyclic monophosphate decreases intracellular free calcium concentrations in cultured vascular smooth muscle cells from rat aorta , 1987, FEBS letters.

[58]  J. Beavo,et al.  Immunological identification of the major platelet low-Km cAMP phosphodiesterase: probable target for anti-thrombotic agents. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[59]  P. Greengard,et al.  9 Phosphorylation of Brain Proteins , 1987 .

[60]  L. Ignarro,et al.  Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates. , 1981, The Journal of pharmacology and experimental therapeutics.

[61]  F. Murad,et al.  Properties and regulation of guanylate cyclase and some proposed functions for cyclic GMP. , 1979, Advances in cyclic nucleotide research.

[62]  G. M. Walton,et al.  Phosphorylation of high mobility group 14 protein by cyclic nucleotide-dependent protein kinases. , 1982, The Journal of biological chemistry.

[63]  F. Jackson,et al.  Cloning, sequence, and expression of the Drosophila cAMP-dependent protein kinase catalytic subunit gene. , 1988, The Journal of biological chemistry.

[64]  W. Welch,et al.  Regulation of actin microfilament integrity in living nonmuscle cells by the cAMP-dependent protein kinase and the myosin light chain kinase , 1988, The Journal of cell biology.

[65]  D. Hr.  Cyclic GMP-dependent protein kinase in intestinal brushborders. , 1981 .

[66]  M. Berridge,et al.  Inositol trisphosphate and diacylglycerol: two interacting second messengers. , 1987, Annual review of biochemistry.

[67]  P. Mäenpää,et al.  Phosphorylation of high mobility group protein HMG 14 by a cyclic GMP-dependent protein kinase from avian liver nucleoli. , 1981, Biochimica et biophysica acta.

[68]  T. Lincoln,et al.  Regulation of intracellular Ca2+ levels in cultured vascular smooth muscle cells. Reduction of Ca2+ by atriopeptin and 8-bromo-cyclic GMP is mediated by cyclic GMP-dependent protein kinase. , 1989, The Journal of biological chemistry.

[69]  J. Hughes,et al.  Role of cyclic GMP in the action of heat-stable enterotoxin of Escherichia coli , 1978, Nature.

[70]  U. Walter,et al.  Regulation of the cellular and subcellular concentrations and distribution of cyclic nucleotide-dependent protein kinases. , 1984, Advances in cyclic nucleotide and protein phosphorylation research.

[71]  T. Lincoln,et al.  Purification and characterization of two forms of cyclic GMP-dependent protein kinase from bovine aorta. , 1988, Journal of Biological Chemistry.

[72]  J. Kuo.  Changes in relative levels of guanosine-3':5'-monophosphate-dependent and adenosine-3':5'-monophosphate-dependent protein kinases in lung, heart, and brain of developing guinea pigs. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[73]  T. Lincoln,et al.  Effects of nitroprusside, glyceryl trinitrate, and 8-bromo cyclic GMP on phosphorylase a formation and myosin light chain phosphorylation in rat aorta. , 1985, Molecular pharmacology.

[74]  F. Murad,et al.  Cyclic guanosine monophosphate as a mediator of vasodilation. , 1986, The Journal of clinical investigation.

[75]  A. Edelman,et al.  Protein serine/threonine kinases. , 1987, Annual review of biochemistry.

[76]  R. Gerzer,et al.  Calcium-induced release from platelet membranes of fatty acids that modulate soluble guanylate cyclase. , 1983, The Journal of pharmacology and experimental therapeutics.

[77]  R. Furchgott.  The role of endothelium in the responses of vascular smooth muscle to drugs. , 1984, Annual review of pharmacology and toxicology.

[78]  Y. Tawada,et al.  Regulation of the plasma membrane Ca2+ pump by cyclic nucleotides in cultured vascular smooth muscle cells. , 1988, The Journal of biological chemistry.

[79]  J. Diamond,et al.  Effects of potassium chloride and smooth muscle relaxants on tension and cyclic nucleotide levels in rat myometrium. , 1975, Canadian journal of physiology and pharmacology.

[80]  M. Verstraete.  Thrombosis and haemostasis 1987 , 1987 .

[81]  E. Böhme,et al.  The primary structure of the 70 kDa subunit of bovine soluble guanylate cyclase , 1988, FEBS letters.

[82]  G. Schultz,et al.  Relaxation of hormonally stimulated smooth muscular tissues by the 8-bromo derivative of cyclic GMP , 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

[83]  K. Jakobs,et al.  Demonstration of cGMP-dependent protein kinase and cGMP-dependent phosphorylation in cell-free extracts of platelets. , 1986, European journal of biochemistry.

[84]  P. Greengard,et al.  Immunological distinction between guanosine 3':5'-monophosphate-dependent and adenosine 3':5'-monophosphate-dependent protein kinases. , 1980, The Journal of biological chemistry.

[85]  W. Siffert,et al.  Protein kinase C enhances Ca2+ mobilization in human platelets by activating Na+/H+ exchange. , 1988, The Journal of biological chemistry.

[86]  J. Laragh,et al.  Atrial natriuretic hormone, the renin-aldosterone axis, and blood pressure-electrolyte homeostasis. , 1985, The New England journal of medicine.

[87]  R. Gerzer,et al.  Activation of soluble guanylate cyclase by arachidonic acid and 15-lipoxygenase products. , 1986, Biochimica et biophysica acta.

[88]  G. Schultz,et al.  Sodium nitroprusside and other smooth muscle-relaxants increase cyclic GMP levels in rat ductus deferens , 1977, Nature.

[89]  D. Glass,et al.  Sites in histone H1 selectively phosphorylated by guanosine 3':5'-monophosphate-dependent protein kinase. , 1981, The Journal of biological chemistry.

[90]  Robert M. Rapoport,et al.  Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation , 1983, Nature.

[91]  S. Moncada,et al.  Vascular endothelial cells synthesize nitric oxide from L-arginine , 1988, Nature.

[92]  M. Melicow,et al.  Isolation of adenosine 3', 5'-monophosphate and guanosine 3', 5'-monophosphate from rat urine. , 1963, Biochemical and biophysical research communications.

[93]  L. Heilmeyer.  Signal Transduction and Protein Phosphorylation , 1987, NATO ASI Series.

[94]  S. Moncada,et al.  Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor , 1987, Nature.

[95]  E. Lapetina,et al.  A role for Gi in control of thrombin receptor-phospholipase C coupling in human platelets. , 1988, The Journal of biological chemistry.

[96]  Y. Nishizuka,et al.  Membrane phospholipid metabolism and signal transduction for protein phosphorylation. , 1984, Advances in cyclic nucleotide and protein phosphorylation research.

[97]  J. Palvimo,et al.  Differential phosphorylation of high mobility group protein hmg 14 from calf thymus and avian erythrocytes by a cyclic gmp-dependent protein kinase. , 1983, Biochemical and biophysical research communications.

[98]  H. C. Hartzell,et al.  Opposite effects of cyclic GMP and cyclic AMP on Ca2+ current in single heart cells , 1986, Nature.

[99]  R. Rapoport.  Cyclic Guanosine Monophosphate Inhibition of Contraction May be Mediated through Inhibition of Phosphatidylinositol Hydrolysis in Rat Aorta , 1986, Circulation research.

[100]  W. Dean,et al.  Regulation of human platelet membrane Ca2+ transport by cAMP- and calmodulin-dependent phosphorylation. , 1987, Biochimica et biophysica acta.

[101]  F. Murad,et al.  Atrial natriuretic peptide binding, cross-linking, and stimulation of cyclic GMP accumulation and particulate guanylate cyclase activity in cultured cells. , 1988, The Journal of biological chemistry.

[102]  F. Murad,et al.  Characterization of the receptor for heat-stable enterotoxin from Escherichia coli in rat intestine. , 1986, The Journal of biological chemistry.

[103]  H. Jonge.  The mechanism of action of Escherichia coli heat-stable toxin. , 1984 .

[104]  D. Macintyre,et al.  Regulation of platelet cytosolic free calcium by cyclic nucleotides and protein kinase C , 1985, FEBS letters.

[105]  P. Greengard,et al.  Cyclic GMP-dependent protein phosphorylation in intact medial tissue and isolated cells from vascular smooth muscle. , 1980, The Journal of biological chemistry.

[106]  D. Øgreid,et al.  Studies of cGMP analog specificity and function of the two intrasubunit binding sites of cGMP-dependent protein kinase. , 1986, The Journal of biological chemistry.

[107]  T. Rink,et al.  Stimulation of Ca2+ efflux from fura‐2‐loaded platelets activated by thrombin or phorbol myristate acetate , 1987, FEBS letters.

[108]  D. Carr,et al.  Stimulation of human platelet guanylate cyclase by fatty acids. , 1977, The Journal of biological chemistry.

[109]  D. Goeddel,et al.  A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor , 1989, Nature.

[110]  T. Lincoln,et al.  Effects of 8-bromo-cGMP on Ca2+ levels in vascular smooth muscle cells: possible regulation of Ca2+-ATPase by cGMP-dependent protein kinase. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[111]  F. Murad,et al.  Atriopeptin II elevates cyclic GMP, activates cyclic GMP-dependent protein kinase and causes relaxation in rat thoracic aorta. , 1985, Biochimica et biophysica acta.

[112]  S. Moncada,et al.  Endothelium-derived relaxing factor. Identification as nitric oxide and role in the control of vascular tone and platelet function. , 1988, Biochemical pharmacology.

[113]  P. Greengard,et al.  Subcellular localization of cyclic GMP-dependent protein kinase and its substrates in vascular smooth muscle. , 1980, The Journal of biological chemistry.

[114]  T. Lincoln,et al.  Cyclic GMP and mechanisms of vasodilation. , 1989, Pharmacology & therapeutics.

[115]  P. Greengard,et al.  Anatomy of cerebellar Purkinje cells in the rat determined by a specific immunohistochemical marker , 1984, Neuroscience.

[116]  D. Glass,et al.  Phosphorylation by cyclic GMP-dependent protein kinase of a synthetic peptide corresponding to the autophosphorylation site in the enzyme. , 1983, The Journal of biological chemistry.

[117]  H. Kanaide,et al.  Cytosolic-free calcium transients in cultured vascular smooth muscle cells: microfluorometric measurements. , 1985, Science.

[118]  D. B. Evans,et al.  Multiple molecular forms of cyclic nucleotide phosphodiesterase in cardiac and smooth muscle and in platelets. Isolation, characterization, and effects of various reference phosphodiesterase inhibitors and cardiotonic agents. , 1986, Biochemical pharmacology.

[119]  R. Sharma,et al.  Coexistence of guanylate cyclase and atrial natriuretic factor receptor in a 180-kD protein. , 1987, Science.

[120]  U. Walter.  Distribution of cyclic-GMP-dependent protein kinase in various rat tissues and cell lines determined by a sensitive and specific radioimmunoassay. , 2005, European journal of biochemistry.

[121]  P. Smith,et al.  Heat-stable enterotoxin of Escherichia coli: in vitro effects on guanylate cyclase activity, cyclic GMP concentration, and ion transport in small intestine. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[122]  F. Hofmann,et al.  A protein kinase activity from rat cerebellum stimulated by guanosine-3':5'-monophosphate. , 1972, Biochemical and biophysical research communications.

[123]  J. Corbin,et al.  Properties of a cGMP-dependent monomeric protein kinase from bovine aorta. , 1989, The Journal of biological chemistry.

[124]  J. Garthwaite,et al.  Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain , 1988, Nature.

[125]  J. Tse,et al.  Increase in nuclear cyclic GMP-dependent protein kinase following partial hepatectomy. , 1981, Life sciences.

[126]  A. Lompré,et al.  Different sensitivity to trypsin of the human platelet plasma and intracellular membrane Ca2+ pumps. , 1988, The Journal of biological chemistry.

[127]  G. Drummond,et al.  Enzymatic hydrolysis of adenosine 3',5'-phosphoric acid. , 1961, The Journal of biological chemistry.

[128]  P. Greengard,et al.  Immunohistochemical localization of cyclic GMP-dependent protein kinase in mammalian brain. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[129]  D. Kalderon,et al.  Molecular cloning and predicted full‐length amino acid sequence of the type Iβ isozyme of cGMP‐dependent protein kinase from human placenta , 1989 .

[130]  H. Rasmussen,et al.  Protein kinase C in the regulation of smooth muscle contraction , 1987, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[131]  J. Meldolesi,et al.  Pathways of Ca2+ influx at the plasma membrane: voltage-, receptor-, and second messenger-operated channels. , 1987, Experimental cell research.

[132]  F. Murad,et al.  cGMP-dependent protein kinase activation in intact tissues. , 1988, Methods in enzymology.

[133]  F. Hofmann,et al.  The cDNA of the two isoforms of bovine cGMP‐dependent protein kinase , 1989, FEBS letters.

[134]  J E Gander,et al.  Magnitude of increase in retinal cGMP metabolic flux determined by 18O incorporation into nucleotide alpha-phosphoryls corresponds with intensity of photic stimulation. , 1983, The Journal of biological chemistry.

[135]  G. Aurbach,et al.  Detection of guanyl cyclase in mammalian tissues. , 1969, Biochimica et biophysica acta.

[136]  P. Greengard,et al.  Protein kinases in the brain. , 1985, Annual review of biochemistry.

[137]  J. Hardman,et al.  Guanyl cyclase, an enzyme catalyzing the formation of guanosine 3',5'-monophosphate from guanosine trihosphate. , 1969, The Journal of biological chemistry.

[138]  E. Sutherland,et al.  THE PROPERTIES OF AN ADENINE RIBONUCLEOTIDE PRODUCED WITH CELLULAR PARTICLES, ATP, Mg++, AND EPINEPHRINE OR GLUCAGON , 1957 .

[139]  M. Cantin,et al.  The atrial natriuretic factor: its physiology and biochemistry. , 1988, Reviews of physiology, biochemistry and pharmacology.

[140]  G. M. Walton,et al.  Purification and characterization of 3':5'-cyclic GMP-dependent protein kinase. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[141]  M. Nelson,et al.  Calcium channels in thrombin-activated human platelet membrane , 1988, Nature.

[142]  E. Lapetina,et al.  The rapid formation of inositol phosphates in human platelets by thrombin is inhibited by prostacyclin. , 1984, The Journal of biological chemistry.

[143]  F. Murad,et al.  Atrial natriuretic factor selectively activates particulate guanylate cyclase and elevates cyclic GMP in rat tissues. , 1984, The Journal of biological chemistry.

[144]  R. Adelstein,et al.  Increased phosphorylation of myosin light chain kinase after an increase in cyclic AMP in intact smooth muscle. , 1984, Science.

[145]  C. Soria,et al.  Possible involvement of two proteins (phosphoprotein and CD9(p24)) in regulation of platelet calcium fluxes , 1985, FEBS letters.

[146]  P. Greengard,et al.  A specific substrate from rabbit cerebellum for guanosine 3':5'-monophosphate-dependent protein kinase. I. Purification and characterization. , 1981, The Journal of biological chemistry.

[147]  T. Brunton.  ON THE USE OF NITRITE OF AMYL IN ANGINA PECTORIS. , 1867 .

[148]  R. Busse,et al.  Endothelium-derived relaxant factor inhibits platelet activation , 1987, Naunyn-Schmiedeberg's Archives of Pharmacology.

[149]  Y. Nishizuka,et al.  Counteraction of calcium-activated, phospholipid-dependent protein kinase activation by adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in platelets. , 1982, Journal of biochemistry.

[150]  A. Hassid.  Atriopeptin II decreases cytosolic free Ca in cultured vascular smooth muscle cells. , 1986, The American journal of physiology.

[151]  F. Hofmann,et al.  A catalytically active fragment of cGMP-dependent protein kinase. Occupation of its cGMP-binding sites does not affect its phosphotransferase activity. , 1987, European journal of biochemistry.

[152]  J. Keirns,et al.  Regulation of cyclic nucleotide concentrations in photoreceptors: an ATP-dependent stimulation of cyclic nucleotide phosphodiesterase by light. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[153]  U. Walter,et al.  Prostaglandin-E 1 - and Sodium Nitroprusside-Regulated Protein Phosphorylation in Platelets , 1987 .

[154]  A. Vaandrager,et al.  Cyclic nucleotide-dependent protein kinase inhibition by H-8: effects on ion transport. , 1988, The American journal of physiology.

[155]  N. Aiyar,et al.  Vasopressin-mediated inhibition of atrial natriuretic factor-stimulated cGMP accumulation in an established smooth muscle cell line. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[156]  P. Greengard,et al.  An endogenous substrate for cGMP-dependent protein kinase in mammalian cerebellum , 1978, Nature.

[157]  F. Hofmann,et al.  Injection of subunits of cyclic AMP-dependent protein kinase into cardiac myocytes modulates Ca2+ current , 1982, Nature.

[158]  R. Gerzer,et al.  The increase of cGMP by atrial natriuretic factor correlates with the distribution of particulate guanylate cyclase , 1985, FEBS letters.

[159]  N. Joyce,et al.  Morphologic and biochemical evidence for a contractile cell network within the rat intestinal mucosa. , 1987, Gastroenterology.

[160]  F. Hofmann,et al.  cGMP‐dependent protein kinase decreases calcium sensitivity of skinned cardiac fibers , 1982, FEBS letters.

[161]  P. Greengard,et al.  Cyclic nucleotide-dependent protein kinases. VI. Isolation and partial purification of a protein kinase activated by guanosine 3',5'-monophosphate. , 1970, The Journal of biological chemistry.

[162]  G. L. Le Breton,et al.  Modulation of Ca2+ fluxes in isolated platelet vesicles: effects of cAMP-dependent protein kinase and protein kinase inhibitor on Ca2+ sequestration and release. , 1987, Biochimica et biophysica acta.

[163]  G. Schultz,et al.  Purification of a soluble, sodium-nitroprusside-stimulated guanylate cyclase from bovine lung. , 1981, European journal of biochemistry.

[164]  J. Beavo,et al.  Isolation and characterization of bovine cardiac muscle cGMP-inhibited phosphodiesterase: a receptor for new cardiotonic drugs. , 1986, Molecular pharmacology.

[165]  F. Murad,et al.  Guanylate cyclase: activation by azide, nitro compounds, nitric oxide, and hydroxyl radical and inhibition by hemoglobin and myoglobin. , 1978, Advances in cyclic nucleotide research.

[166]  E. Krebs,et al.  Concentrations of cyclic AMP-dependent protein kinase subunits in various tissues. , 1977, The Journal of biological chemistry.

[167]  F. Murad,et al.  Myosin light chain phosphorylation in contraction and relaxation of intact rat thoracic aorta. , 1986, The International journal of biochemistry.

[168]  E. Haber,et al.  The heart and cardiovascular system , 1986 .

[169]  S. Sage,et al.  The kinetics of changes in intracellular calcium concentration in fura-2-loaded human platelets. , 1987, The Journal of biological chemistry.

[170]  E Carafoli.  Intracellular calcium homeostasis. , 1987, Annual review of biochemistry.

[171]  W. George,et al.  Elevation of guanosine 3',5'-cyclic phosphate in rat heart after perfusion with acetylcholine. , 1970, Proceedings of the National Academy of Sciences of the United States of America.

[172]  N. Joyce,et al.  Pericytes, like vascular smooth muscle cells, are immunocytochemically positive for cyclic GMP-dependent protein kinase. , 1984, Microvascular research.

[173]  L. Stryer,et al.  Highly cooperative feedback control of retinal rod guanylate cyclase by calcium ions , 1988, Nature.

[174]  J. Nargeot,et al.  Direct evidence for the modulation of human platelet cytosolic free Ca2+ by intracellular cyclic AMP produced with a photoactivatable derivative. , 1987, Biochemical and biophysical research communications.

[175]  T. Lincoln,et al.  Regulation of cardiac cyclic GMP-dependent protein kinase. , 1981, Biochimica et biophysica acta.

[176]  M. Shoji,et al.  Stimulatory modulator of guanosine 3':5'-monophosphate-dependent protein kinase from mammalian tissues. , 1976, Biochimica et biophysica acta.

[177]  L. Stryer,et al.  Cyclic GMP cascade of vision. , 1986, Annual review of neuroscience.

[178]  G. Rubin,et al.  cGMP-dependent protein kinase genes in Drosophila. , 1989, The Journal of biological chemistry.

[179]  F. Hofmann,et al.  Phosphorylation of cGMP-dependent protein kinase increases the affinity for cyclic AMP. , 1986, European journal of biochemistry.

[180]  F. Murad,et al.  Soluble guanylate cyclase from rat lung exists as a heterodimer. , 1986, The Journal of biological chemistry.

[181]  P. Miller,et al.  Studies on regulation and cellular localization of cAMP- and cGMP-dependent protein kinases. , 1982, Progress in clinical and biological research.

[182]  P. Greengard,et al.  The cyclic nucleotide-dependent phosphorylation of aortic smooth muscle membrane proteins. , 1987, Archives of biochemistry and biophysics.

[183]  H. Nakamura,et al.  Cyclic GMP regulation of the plasma membrane (Ca2+-Mg2+)ATPase in vascular smooth muscle. , 1987, Journal of biochemistry.

[184]  J. Beavo,et al.  Stimulation of adenosine 3',5'-monophosphate hydrolysis by guanosine 3',5'-monophosphate. , 1971, The Journal of biological chemistry.

[185]  G. Schultz,et al.  Soluble guanylate cyclase purified from bovine lung contains heme and copper , 1981, FEBS letters.

[186]  A. D. de Bold,et al.  A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats. , 1981, Life sciences.

[187]  H. Schmidt,et al.  Arginine is a physiological precursor of endothelium-derived nitric oxide. , 1988, European journal of pharmacology.

[188]  F. Hofmann,et al.  Regulation of the L-type calcium channel , 1987 .

[189]  N. Sperelakis,et al.  Cyclic nucleotides depress action potentials in cultured aortic smooth muscle cells. , 1987, European journal of pharmacology.

[190]  K. Morgan,et al.  Alteration of cytoplasmic ionized calcium levels in smooth muscle by vasodilators in the ferret. , 1984, The Journal of physiology.

[191]  F. Murad,et al.  Agonist‐Induced Endothelium‐Dependent Relaxation in Rat Thoracic Aorta May Be Mediated through cGMP , 1983, Circulation research.

[192]  F. Murad,et al.  Endothelium-dependent and nitrovasodilator-induced activation of cyclic GMP-dependent protein kinase in rat aorta. , 1983, Journal of cyclic nucleotide and protein phosphorylation research.

[193]  S. Snyder,et al.  Cyclic AMP-dependent phosphorylation of a brain inositol trisphosphate receptor decreases its release of calcium. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[194]  T. Lincoln,et al.  Angiotensin decreases cyclic GMP accumulation produced by atrial natriuretic factor. , 1987, The American journal of physiology.

[195]  M. Scrutton.  Platelets: Cellular Response Mechanisms and their Biological Significance , 1981 .

[196]  F. Hofmann,et al.  Cyclic GMP-dependent protein kinase phosphorylates phospholamban in isolated sarcoplasmic reticulum from cardiac and smooth muscle. , 1988, The Biochemical journal.

[197]  P. Greengard,et al.  cGMP-dependent protein kinase enhances Ca2+ current and potentiates the serotonin-induced Ca2+ current increase in snail neurones , 1986, Nature.

[198]  A. Guidotti,et al.  Ontogenetic studies of cGMP‐dependent protein kinase in rat cerebellum , 1979, Journal of neurochemistry.

[199]  U. Walter,et al.  Cyclic nucleotide elevating vasodilators inhibit platelet aggregation at an early step of the activation cascade. , 1989, European journal of pharmacology.

[200]  H. Hidaka,et al.  Phorbol ester-induced activation of human platelets is associated with protein kinase C phosphorylation of myosin light chains , 1983, Nature.

[201]  U. Walter,et al.  Vasodilator-stimulated protein phosphorylation in platelets is mediated by cAMP- and cGMP-dependent protein kinases. , 1987, European journal of biochemistry.

[202]  U. Walter,et al.  Dibutyryl cAMP treatment of neuroblastoma‐glioma hybrid cells results in selective increase in cAMP‐receptor protein (R‐I) as measured by monospecific antibodies. , 1983, The EMBO journal.

[203]  A. Vardanis.  A unique cyclic nucleotide-dependent protein kinase. , 1980, Journal of Biological Chemistry.