Combined diode laser cyclophotocoagulation and intravitreal bevacizumab (Avastin) in neovascular glaucoma

Background:  Intravitreal injection of bevacizumab (Avastin) in eyes with neovascular glaucoma (NVG) has recently been shown to induce rapid regression of anterior segment neovascularization and has promise as adjunct treatment to diode laser cyclophotocoagulation (CPC) to control intraocular pressure (IOP). This study presents the outcome of concomitant treatment with CPC and intravitreal bevacizumab in painful poor visual potential eyes in a case series of consecutively diagnosed NVG.

[1]  Y. Tano,et al.  Intravitreal bevacizumab to treat iris neovascularization and neovascular glaucoma secondary to ischemic retinal diseases in 41 consecutive cases. , 2008, Ophthalmology.

[2]  W. Tasman,et al.  COMBINATION INTRAVITREAL BEVACIZUMAB/PANRETINAL PHOTOCOAGULATION VERSUS PANRETINAL PHOTOCOAGULATION ALONE IN THE TREATMENT OF NEOVASCULAR GLAUCOMA , 2008, Retina.

[3]  A. Metheetrairut,et al.  Surgical outcome of intravitreal bevacizumab and filtration surgery in neovascular glaucoma , 2008, Advances in therapy.

[4]  S. Garg,et al.  Role of intravitreal bevacizumab in neovascular glaucoma. , 2007, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

[5]  S. Yazdani,et al.  Intravitreal bevacizumab (Avastin) injection for neovascular glaucoma. , 2007, Journal of glaucoma.

[6]  J. Grigg,et al.  Bevacizumab (Avastin) for the treatment of neovascular glaucoma , 2007, Clinical & experimental ophthalmology.

[7]  M. Iliev,et al.  Long-term outcome of trans-scleral diode laser cyclophotocoagulation in refractory glaucoma , 2007, British Journal of Ophthalmology.

[8]  S. Mohammadi,et al.  Pars plana Ahmed valve implant and vitrectomy in the management of neovascular glaucoma. , 2006, Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye.

[9]  M. Nagpal,et al.  The use of intravitreal bevacizumab in neovascular glaucoma: a case report. , 2007, Bulletin de la Societe belge d'ophtalmologie.

[10]  S. Wolf,et al.  Intravitreal bevacizumab (Avastin) in the treatment of neovascular glaucoma. , 2006, American journal of ophthalmology.

[11]  Michael A. Albert,et al.  Regression of neovascular iris vessels by intravitreal injection of bevacizumab. , 2006, Retina.

[12]  I. Scott,et al.  Short-term results of intravitreal bevacizumab (Avastin) on anterior segment neovascularization in neovascular glaucoma. , 2006, Acta ophthalmologica Scandinavica.

[13]  F. Davidorf,et al.  Rapid improvement of rubeosis iridis from a single bevacizumab (Avastin) injection. , 2006, Retina.

[14]  J. Diamond,et al.  A two centre study of the dose-response relation for transscleral diode laser cyclophotocoagulation in refractory glaucoma , 2003, The British journal of ophthalmology.

[15]  J. Sivak-Callcott,et al.  Evidence-based recommendations for the diagnosis and treatment of neovascular glaucoma. , 2001, Ophthalmology.

[16]  K. Martin,et al.  Cyclodiode laser therapy for painful, blind glaucomatous eyes , 2001, The British journal of ophthalmology.

[17]  M. Walland Diode laser cyclophotocoagulation: longer term follow up of a standardized treatment protocol , 2000, Clinical & experimental ophthalmology.

[18]  K. Chalam,et al.  Increased level of vascular endothelial growth factor in aqueous humor of patients with neovascular glaucoma. , 1998, Ophthalmology.

[19]  Joan W. Miller,et al.  Vascular endothelial growth factor is sufficient to produce iris neovascularization and neovascular glaucoma in a nonhuman primate. , 1996, Archives of ophthalmology.

[20]  E S Gragoudas,et al.  Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate. , 1996, Archives of ophthalmology.

[21]  P. Khaw,et al.  Combined transscleral diode laser cyclophotocoagulation and transscleral retinal photocoagulation for refractory neovascular glaucoma. , 1996, Retina.

[22]  G. Brown,et al.  Efficacy of panretinal photocoagulation in preventing neovascular glaucoma following ischemic central retinal vein obstruction. , 1982, Ophthalmology.

[23]  R. Smith Rubeotic glaucoma. , 1981, British Journal of Ophthalmology.

[24]  W. Tasman,et al.  Effects of argon laser photocoagulation on rubeosis iridis and angle neovascularization. , 1980, Ophthalmology.

[25]  W. M. Grant,et al.  Effects of panretinal photocoagulation on rubeosis iridis, angle neovascularization, and neovascular glaucoma. , 1978, American journal of ophthalmology.