Gold nanoparticles decorated liposomes and their SERS performance in tumor cells

Due to their unique properties, liposomes have been widely used as drug nanocarriers. Herein a liposome-Au nanohybrid has been demonstrated as a SERS active intracellular drug nanocarrier. In this study, cationic Raman reporter tagged gold nanoparticles (Au@4MBA@PAH) were anchored onto the surfaces of anionic liposomes via electrostatic interactions. Using SKBR3 cells as model cells, we revealed that the hybrid formulation can be effectively taken up by tumor cells and tracked by the SERS signals. Collectively, the liposome-Au nanohybrids hold great promise in biomedical applications.

[1]  Sebastian Schlücker,et al.  Label-free SERS monitoring of chemical reactions catalyzed by small gold nanoparticles using 3D plasmonic superstructures. , 2013, Journal of the American Chemical Society.

[2]  G. Frens Controlled Nucleation for the Regulation of the Particle Size in Monodisperse Gold Suspensions , 1973 .

[3]  John C Kraft,et al.  Emerging research and clinical development trends of liposome and lipid nanoparticle drug delivery systems. , 2014, Journal of pharmaceutical sciences.

[4]  Kostas Kostarelos,et al.  Liposomes: from a clinically established drug delivery system to a nanoparticle platform for theranostic nanomedicine. , 2011, Accounts of chemical research.

[5]  Liangfang Zhang,et al.  Hydrogel Containing Nanoparticle-Stabilized Liposomes for Topical Antimicrobial Delivery , 2014, ACS nano.

[6]  Mark B. Carter,et al.  Erratum: The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers (Nature Materials (2011) 10 (389-397)) , 2011 .

[7]  P. McEuen,et al.  Supported lipid bilayer/carbon nanotube hybrids. , 2007, Nature nanotechnology.

[8]  Alaaldin M. Alkilany,et al.  Gold nanorods: their potential for photothermal therapeutics and drug delivery, tempered by the complexity of their biological interactions. , 2012, Advanced drug delivery reviews.

[9]  C Jeffrey Brinker,et al.  Electrostatically mediated liposome fusion and lipid exchange with a nanoparticle-supported bilayer for control of surface charge, drug containment, and delivery. , 2009, Journal of the American Chemical Society.

[10]  Zhe Wang,et al.  Photosensitizer-conjugated silica-coated gold nanoclusters for fluorescence imaging-guided photodynamic therapy. , 2013, Biomaterials.

[11]  Bing Yan,et al.  SERS tags: novel optical nanoprobes for bioanalysis. , 2013, Chemical reviews.

[12]  M. Yeh,et al.  Clinical development of liposome-based drugs: formulation, characterization, and therapeutic efficacy , 2011, International journal of nanomedicine.

[13]  A. Bangham,et al.  Diffusion of univalent ions across the lamellae of swollen phospholipids. , 1965, Journal of molecular biology.

[14]  Hye-Young Park,et al.  Size Correlation of Optical and Spectroscopic Properties for Gold Nanoparticles , 2007 .

[15]  P. Cullis,et al.  Liposomal drug delivery systems: from concept to clinical applications. , 2013, Advanced drug delivery reviews.

[16]  Lain-Jong Li,et al.  Integrating carbon nanotubes and lipid bilayer for biosensing. , 2010, Biosensors & bioelectronics.

[17]  Steve Granick,et al.  How to stabilize phospholipid liposomes (using nanoparticles). , 2006, Nano letters.

[18]  Tuan Vo-Dinh,et al.  Gold Nanostars For Surface-Enhanced Raman Scattering: Synthesis, Characterization and Optimization. , 2008, The journal of physical chemistry. C, Nanomaterials and interfaces.