Inhibition of transcription factors with small organic molecules.
暂无分享,去创建一个
[1] T. Berg. Signal Transducers and Activators of Transcription as Targets for Small Organic Molecules , 2008, Chembiochem : a European journal of chemical biology.
[2] Judith M. Müller,et al. Discovery of Chromone‐Based Inhibitors of the Transcription Factor STAT5 , 2008, Chembiochem : a European journal of chemical biology.
[3] D. Boger,et al. Disruption of the MYC transcriptional function by a small-molecule antagonist of MYC/MAX dimerization. , 2008, Oncology reports.
[4] William P. Katt,et al. An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects. , 2007, ACS chemical biology.
[5] Dirk Eick,et al. Transcribing RNA Polymerase II Is Phosphorylated at CTD Residue Serine-7 , 2007, Science.
[6] Christopher L. McClendon,et al. Reaching for high-hanging fruit in drug discovery at protein–protein interfaces , 2007, Nature.
[7] M. Raes,et al. Dual effect of echinomycin on hypoxia‐inducible factor‐1 activity under normoxic and hypoxic conditions , 2007, The FEBS journal.
[8] G. Semenza,et al. Hypoxia-Inducible Factor 1 (HIF-1) Pathway , 2007, Science's STKE.
[9] G. Semenza. Evaluation of HIF-1 inhibitors as anticancer agents. , 2007, Drug discovery today.
[10] R. Kornberg,et al. The molecular basis of eukaryotic transcription (Nobel Lecture). , 2007, Angewandte Chemie.
[11] P. Dervan,et al. Modulating hypoxia-inducible transcription by disrupting the HIF-1-DNA interface. , 2007, ACS chemical biology.
[12] A. Mapp,et al. Disrupting Mediator with a Short Peptide Ligand , 2007, Chembiochem : a European journal of chemical biology.
[13] Bianca Sperl,et al. Selective Inhibition of c‐Myc/Max Dimerization by a Pyrazolo[1,5‐a]pyrimidine , 2007, ChemMedChem.
[14] W. Guida,et al. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity , 2007, Proceedings of the National Academy of Sciences.
[15] J. McMurray,et al. Solid-phase synthesis of Stat3 inhibitors incorporating O-carbamoylserine and O-carbamoylthreonine as glutamine mimics. , 2007, Bioorganic & medicinal chemistry letters.
[16] John P. Overington,et al. How many drug targets are there? , 2006, Nature Reviews Drug Discovery.
[17] Bianca Sperl,et al. Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. , 2006, Chemistry & biology.
[18] P. Imming,et al. Drugs, their targets and the nature and number of drug targets , 2006, Nature Reviews Drug Discovery.
[19] M. Henriksson,et al. Myc Overexpression Enhances Apoptosis Induced by Small Molecules , 2006, Cell cycle.
[20] D. Felsher,et al. Tumor Dormancy: Death and Resurrection of Cancer As Seen through Transgenic Mouse Models , 2006, Cell cycle.
[21] B. Groner,et al. The Biological Functions of the Versatile Transcription Factors STAT3 and STAT5 and New Strategies for their Targeted Inhibition , 2006, Journal of Mammary Gland Biology and Neoplasia.
[22] M. Cole,et al. Mechanism of transcriptional activation by the Myc oncoproteins. , 2006, Seminars in cancer biology.
[23] Kathryn A. O’Donnell,et al. The c-Myc target gene network. , 2006, Seminars in cancer biology.
[24] M. Henriksson,et al. The Myc oncoprotein as a therapeutic target for human cancer. , 2006, Seminars in cancer biology.
[25] P. Dervan,et al. Programmable oligomers for minor groove DNA recognition. , 2006, Journal of the American Chemical Society.
[26] R. Shoemaker,et al. Targeting the PAS-A Domain of HIF-1α for Development of Small Molecule Inhibitors of HIF-1 , 2006, Cell cycle.
[27] Hans‐Dieter Arndt. Small molecule modulators of transcription. , 2006, Angewandte Chemie.
[28] Dirk Eick,et al. Selective inhibition of c-Myc/Max dimerization and DNA binding by small molecules. , 2006, Chemistry & biology.
[29] A. Chapman-Smith,et al. Novel DNA Binding by a Basic Helix-Loop-Helix Protein , 2006, Journal of Biological Chemistry.
[30] M. Henriksson,et al. Identification of small molecules that induce apoptosis in a Myc-dependent manner and inhibit Myc-driven transformation. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[31] P. Vogt,et al. A credit-card library approach for disrupting protein-protein interactions. , 2006, Bioorganic & medicinal chemistry.
[32] J. Grandis,et al. STAT3 as a therapeutic target in head and neck cancer , 2006, Expert opinion on biological therapy.
[33] Chinmay Y. Majmudar,et al. Chemical approaches to transcriptional regulation. , 2005, Current opinion in chemical biology.
[34] A. Monks,et al. Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. , 2005, Cancer research.
[35] M. Eilers,et al. Transcriptional regulation and transformation by Myc proteins , 2005, Nature Reviews Molecular Cell Biology.
[36] J. Darnell,et al. Validating Stat3 in cancer therapy , 2005, Nature Medicine.
[37] D. Scudiero,et al. A high-throughput fluorescence-anisotropy screen that identifies small molecule inhibitors of the DNA binding of B-ZIP transcription factors. , 2005, Analytical biochemistry.
[38] Renxiao Wang,et al. A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[39] J. Klco,et al. Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[40] J. Turkson,et al. Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity. , 2004, Molecular cancer therapeutics.
[41] John S Lazo,et al. Low molecular weight inhibitors of Myc–Max interaction and function , 2003, Oncogene.
[42] Stephen K. Burley,et al. X-Ray Structures of Myc-Max and Mad-Max Recognizing DNA Molecular Bases of Regulation by Proto-Oncogenic Transcription Factors , 2003, Cell.
[43] A. Hopkins,et al. The druggable genome , 2002, Nature Reviews Drug Discovery.
[44] D. Boger,et al. Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[45] W. Delano. The PyMOL Molecular Graphics System , 2002 .
[46] J. Turkson,et al. Phosphotyrosyl Peptides Block Stat3-mediated DNA Binding Activity, Gene Regulation, and Cell Transformation* , 2001, The Journal of Biological Chemistry.
[47] B. Kräutler,et al. Structure, function, and dynamics of the dimerization and DNA-binding domain of oncogenic transcription factor v-Myc. , 2001, Journal of molecular biology.
[48] S. Becker,et al. Three-dimensional structure of the Stat3β homodimer bound to DNA , 1998, Nature.
[49] W. DeGrado,et al. DNA-induced increase in the alpha-helical content of C/EBP and GCN4. , 1991, Biochemistry.