Analysis of the Code Relating Sequence to Secondary Structure in Proteins

PROTEIN conformation depends for its specificity and stability on the interactions of side-chain groups. A complete analysis of the stability of such frequently occurring features as helical regions in terms of the energy of interaction of atoms and groups of atoms is very complex, and there has therefore been considerable interest in empirical rules for the formation of helical regions1,2. Attempts have been made to correlate helicity with amino-acids taken singly3–6 and in pairs7,9. The importance of amino-acid sequence as well as content has been established8,9.

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