Food, reproduction and longevity: is the extended lifespan of calorie-restricted animals an evolutionary adaptation?

Calorie restriction results in an increased lifespan and reduced fecundity of rodents. In a natural environment the availability of food will vary greatly. It is suggested that Darwinian fitness will be increased if animals cease breeding during periods of food deprivation and invest saved resources in maintenance of the adult body, or soma. This would increase the probability of producing viable offspring during an extended lifespan. The diversion of limited energy resources from breeding to maintenance of the soma is seen as an evolutionary adaptation, fully compatible with the 'disposable soma' theory of the evolution of ageing.

[1]  B. Merry,et al.  THE EXPERIMENTAL MANIPULATION OF AGEING BY DIET , 1986, Biological reviews of the Cambridge Philosophical Society.

[2]  E. Masoro.  State of knowledge on action of food restriction and aging. , 1985, Basic life sciences.

[3]  R B Setlow,et al.  Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[4]  A. Schwartz,et al.  Inverse correlation between species life span and capacity of cultured fibroblasts to bind 7,12-dimethylbenz(a)anthracene to DNA. , 1977, Experimental cell research.

[5]  R. Holliday.  Toward a Biological Understanding of the Ageing Process , 2015, Perspectives in biology and medicine.

[6]  A. Schwartz,et al.  Effect of food restriction, dehydroepiandrosterone, or obesity on the binding of 3H-7,12-dimethylbenz(a)anthracene to mouse skin DNA. , 1983, Journal of gerontology.

[7]  R. Walford,et al.  Correlation between ultraviolet-induced DNA repair in primate lymphocytes and fibroblasts and species maximum achievable life span , 1984, Mechanisms of Ageing and Development.

[8]  B. Merry,et al.  Lifetime breeding studies in fully fed and dietary restricted female CFY Sprague-Dawley rats. 1. Effect of age, housing conditions and diet on fecundity , 1985, Mechanisms of Ageing and Development.

[9]  D. Röhme.  Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[10]  Y. Courtois,et al.  Correlation between DNA excision repair and mammalian lifespan in lens epithelial cells. , 1982, Cell biology international reports.

[11]  T. Kirkwood,et al.  The biology of human ageing: Ageing as a consequence of natural selection , 1986 .

[12]  A. Aiyar,et al.  Some biochemical parameters of ageing in relation to dietary protein , 1983, Mechanisms of Ageing and Development.

[13]  V. L. Wilson,et al.  DNA methylation decreases in aging but not in immortal cells. , 1983, Science.

[14]  B. Merry,et al.  Onset of puberty and duration of fertility in rats fed a restricted diet. , 1979, Journal of reproduction and fertility.

[15]  W. Lee,et al.  The relationship of DNA excision repair of ultraviolet-induced lesions to the maximum life span of mammals , 1981, Mechanisms of Ageing and Development.

[16]  T. Johnson,et al.  A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. , 2002, Genetics.

[17]  T. Kirkwood,et al.  The evolution of ageing and longevity , 1979, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[18]  B. Merry,et al.  Serum profiles of LH, FSH, testosterone and 5α-DHT from 21 to 1000 days of age in AD Libitum fed and dietary restricted rats , 1981, Experimental Gerontology.

[19]  T. Kirkwood.  Evolution of ageing , 1977, Nature.

[20]  M. R. Mickey,et al.  Survival and disease patterns in C57BL/6J mice subjected to undernutrition , 1980, Experimental Gerontology.

[21]  M B VISSCHER,et al.  The effects of dietary caloric restriction on maturity and senescence, with particular reference to fertility and longevity. , 1947, The American journal of physiology.