Alexander Haddow, 18 January 1907 - 21 January 1976

The central figure of this biographical memoir, Alexander Haddow (‘Alex’ to many so that reference to him by this name will continue throughout the following pages), worked a year or two before his death on a draft for a full autobiography with its introductory chapter headed ‘Prolegomena’; it was never finished or published, except in form of a short version [94].* If it had been completed in time and edited, it would have been the ideal record of his life. As it will be gratefully acknowledged later on, I made, I hope, good use of these valuable notes (38),f dictated by a totally blind man, especially those pertaining to his origins, childhood, schooldays and university studies. In addition, I employed as excellent sources his own ventures into biographical studies, such as the extended version of the Fourth Kennaway Memorial Lecture [92], informative obituaries and his numerous publications of research results or essays with more contemplative, speculative and philosophical contents. Furthermore, apart from having access to some of his correspondence with eminent contemporaries, I was also greatly helped through recent contacts, mainly by exchange of letters with a considerable number of people who knew him well, to refresh my own recollections of him, stretching back over forty years, and to extend my knowledge of periods outside my personal experience.

[1]  A. Haddow,et al.  Tumour Growth-inhibitory Alkyl Sulphonates , 1956, Nature.

[2]  A. Haddow Addendum to "molecular repair, wound healing, and carcinogenesis: tumor production a possible overhealing"? , 1974, Advances in cancer research.

[3]  A. Haddow The influence of carcinogenic substances on sarcomata induced by the same and other compounds , 1938 .

[4]  W. Ross The interaction of chlorambucil with human γ-globulin , 1974 .

[5]  D. Galton Myleran in chronic myeloid leukaemia; results of treatment. , 1953, Lancet.

[6]  J. Wolff,et al.  Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid. , 1948, The New England journal of medicine.

[7]  A. Haddow On the Biological Alkylating Agents , 1972, Recenti progressi in medicina.

[8]  A. Haddow,et al.  The Influence of Various Polycyclic Hydrocarbons on the Growth Rate of Transplantable Tumours , 1937 .

[9]  J. Watkinson,et al.  Plasma Acid Phosphatase in Carcinoma of Prostate: Effect of Stilboestrol , 1944, British medical journal.

[10]  A. Haddow,et al.  Myleran in chronic myeloid leukaemia; chemical constitution and biological action. , 1953, Lancet.

[11]  R. Scott The Chemotherapy of Malignant Disease* , 1958, British medical journal.

[12]  A. Haddow Chemical carcinogens and their modes of action. , 1958, British medical bulletin.

[13]  A. Haddow The Artificial Induction of Coat Colour—a Final Report and a Review , 2015, Perspectives in biology and medicine.

[14]  A. Haddow The influence of carcinogenic compounds and related substances on the rate of growth of spontaneous tumours of the mouse , 1938 .

[15]  J. Shirlaw THE METABOLISM OF TUMOURS , 1931 .

[16]  P. D. Lawley The relative reactivities of deoxyribonucleotides and of the bases of DNA towards alkylating agents. , 1957, Biochimica et biophysica acta.

[17]  J. Miller,et al.  Immunological function of the thymus. , 1961, Lancet.

[18]  J. Trosko,et al.  Platinum Compounds: a New Class of Potent Antitumour Agents , 1969, Nature.

[19]  A. Haddow,et al.  A Perspective in Time , 2015, Perspectives in biology and medicine.

[20]  P. D. Lawley Mechanism of Action of Alkylating Agents: Comparisons with other Cytotoxic, Mutagenic and Carcinogenic Agents , 1966 .

[21]  J. Roberts,et al.  Metabolic and Chemical Studies of ‘Myleran’: Formation of 3-Hydroxytetrahydrothiophene-1,1-Dioxide In Vivo, and Reactions With Thiols In Vitro , 1959, Nature.

[22]  W. V. Mayneord On a Law of Growth of Jensen's Rat Sarcoma , 1932 .

[23]  R. Wade,et al.  The use of macromolecules as carriers of cytotoxic groups (part II) nitrogen mustard--protein complexes. , 1972, Neoplasma.

[24]  A. Haddow Erythrocyte individuality in relation to the transplantation of an induced fowl sarcoma , 1934 .

[25]  A. Haddow,et al.  The inhibition of growth by chemical compounds , 1942, Proceedings of the Royal Society of London. Series B - Biological Sciences.

[26]  A. Haddow Mode of action of chemical carcinogens. , 1946, British medical bulletin.

[27]  W. Ross The conjugation of chlorambucil with human gamma-globulin: confirmation that the drug is bound in an active form. , 1975, Chemico-biological interactions.

[28]  R. J. GOLDACRE,et al.  Mode of Production of Chromosome Abnormalities by the Nitrogen Mustards The Possible Role of Cross-Linking , 1949, Nature.

[29]  L. Hogben Francis Albert Eley Crew, 1886-1973 , 1974, Biographical Memoirs of Fellows of the Royal Society.

[30]  A. Haddow Biological Hazards of Atomic Energy: Being the Papers Read at the Conference Convened by the Institute of Biology and the Atomic Scientists' Association, October, 1950 , 1952 .

[31]  A. Haddow,et al.  The Association of Carcinogenicity and Growth-Inhibitory Power in the Polycyclic Hydrocarbons and other Substances , 1939 .

[32]  A. Haddow The biochemistry of cancer. , 1955, Annual review of biochemistry.

[33]  A. Gutman,et al.  AN " ACID " PHOSPHATASE OCCURRING IN THE SERUM OF PATIENTS WITH METASTASIZING CARCINOMA OF THE PROSTATE GLAND. , 1938, The Journal of clinical investigation.

[34]  A. Haddow,et al.  The influence of certain carcinogenic and other hydrocarbons on body growth in the rat. , 1937 .

[35]  A. Haddow On Secondary Colony Development In Bacteria And An Analogy With Tumour Production In Higher Forms , 1937 .

[36]  R. Robinson,et al.  Œstrogenic Activity of Certain Synthetic Compounds , 1938, Nature.

[37]  R. Linstead George Armand Robert Kon 1892-1951 , 1952, Obituary Notices of Fellows of the Royal Society.

[38]  J. Broome Evidence that the L-Asparaginase Activity of Guinea Pig Serum is responsible for its Antilymphoma Effects , 1961, Nature.

[39]  A HADDOW Advances in the Study of Chemical Carcinogenesis , 1951, Proceedings of the Royal Society of Medicine.

[40]  G. I. Bell Models of carcinogenesis as an escape from mitotic inhibitors. , 1976, Science.

[41]  P. Brookes Covalent interaction of carcinogens with DNA. , 1975, Life sciences.

[42]  J. Roberts,et al.  Metabolism of Myleran (1 : 4-Dimethanesulphonyloxybutane) , 1959, Nature.

[43]  A. Haddow IMMUNOLOGY OF THE CANCER CELL: TUMOUR-SPECIFIC ANTIGENS. , 1965, British medical bulletin.

[44]  P. Brookes Quantitative aspects of the reaction of some carcinogens with nucleic acids and the possible significance of such reactions in the process of carcinogenesis. , 1966, Cancer research.

[45]  A. Haddow Mode of action of carcinogenic agents on cells. , 1953, Acta - Unio Internationalis Contra Cancrum.

[46]  A. Haddow An autobiographical essay. , 1974, Cancer research.

[47]  H. Holzer,et al.  Molekulare Biologie des Malignen Wachstums , 1966 .

[48]  R. Wade,et al.  Some Serum Protein Nitrogen Mustard Complexes with High Chemotherapeutic Selectivity , 1967, Nature.

[49]  I. Blake,et al.  Neoplasms in fish: A report of six cases with a summary of the literature , 1933 .

[50]  E. Boyland COLLOIDAL SOLUTIONS OF 1 : 2 : 5 : 6-DIBENZANTHRACENE , 1932 .

[51]  A. Haddow,et al.  Influence of Synthetic Oestrogens on Advanced Malignant Disease , 1944, British medical journal.

[52]  C. Huggins,et al.  Studies on prostatic cancer: I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate , 1941, CA: a cancer journal for clinicians.

[53]  I. Pastan,et al.  Cell surface protein partially restores morphology, adhesiveness, and contact inhibition of movement to transformed fibroblasts. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[54]  A. Haddow Note on the chemotherapy of cancer. , 1946, British medical bulletin.

[55]  A. Haddow,et al.  Influence of Certain Polycyclic Hydrocarbons on the Growth of the Jensen Rat Sarcoma , 1935, Nature.

[56]  A. Haddow,et al.  Chemistry of carcinogenic compounds. , 1946, British medical bulletin.

[57]  R. Wade,et al.  The use of macromolecules as carriers of cytotoxic groups (part I) conjugates of nitrogen mustards with proteins, polypeptidyl proteins and polypeptides. , 1972, Neoplasma.

[58]  H. Richmond Induction of Sarcoma in the Rat by Iron—Dextran Complex , 1959, British medical journal.

[59]  P. D. Lawley,et al.  Tissue distribution and mode of DNA methylation in mice by methyl methanesulphonate and N-methyl-N′-nitro-N-nitrosoguanidine: Lack of thymic lymphoma induction and low extent of methylation of target tissue DNA at O-6 of guanine , 1976 .

[60]  F. Bergel Carcinogenic hazards in natural and man-made environments , 1974, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[61]  A. Haddow Oncology: its scope and prospects. , 1971, Proceedings of the Royal Society of Medicine.

[62]  C. Oberling Neoplastic Diseases (Cancer) , 1959 .

[63]  A. Haddow Transformation of Cells and Viruses , 1944, Nature.

[64]  A. Haddow The application of vital staining to the histogenesis of the rous sarcoma i , 1933 .

[65]  A. Haddow The Liver in Relation to Normal and Malignant Growth: A Review , 1934 .

[66]  A. Haddow The biological characters of spontaneous tumours of the mouse, with special reference to rate of growth , 1938 .

[67]  F. Bergel Some Chemical Aspects Of Abnormal Growth , 1954, Nature.

[68]  R. Harvey,et al.  The reaction of (±)‐7α, 8β‐dihydroxy‐9β, 10β‐epoxy‐7,8,9,10‐tetrahydrobenzo(a)pyrene with dna , 1976 .

[69]  T. A. Connors,et al.  Platinum Coordination Complexes in Cancer Chemotherapy , 1974, Recent Results in Cancer Research.