New insights into the pathology of white matter tracts in cerebral palsy from diffusion magnetic resonance imaging: a systematic review

Aim  Structural connectivity analysis using diffusion magnetic resonance imaging (dMRI) and tractography has become the method of choice for studying white matter pathology and reorganization in children with congenital hemiplegia. To evaluate its role in the research domain, we systematically reviewed the literature about children with cerebral palsy (CP) to document common findings and identify strengths and possible limitations of this neuroimaging technology.

[1]  S. Jang,et al.  Diffusion tensor imaging demonstrates focal lesions of the corticospinal tract in hemiparetic patients with cerebral palsy , 2007, Neuroscience Letters.

[2]  K. Himmelmann,et al.  Function and neuroimaging in cerebral palsy: a population‐based study , 2011, Developmental medicine and child neurology.

[3]  Iwona Stepniewska,et al.  Thalamocortical connections of functional zones in posterior parietal cortex and frontal cortex motor regions in New World monkeys. , 2010, Cerebral cortex.

[4]  J. Shimony,et al.  Imaging for Diagnosis and Treatment of Cerebral Palsy , 2008, Clinical obstetrics and gynecology.

[5]  P. O'mahony,et al.  Interrater reliability of the Melbourne Assessment of Unilateral Upper Limb Function for children with hemiplegic cerebral palsy. , 2011, The American journal of occupational therapy : official publication of the American Occupational Therapy Association.

[6]  Daniel C. Alexander,et al.  Chapter 4 – Multiple Fibers: Beyond the Diffusion Tensor , 2009 .

[7]  R. Henry,et al.  Diffusion Tensor MR Imaging Tractography of the Pyramidal Tracts Correlates with Clinical Motor Function in Children with Congenital Hemiparesis , 2007, American Journal of Neuroradiology.

[8]  G. Birbeck,et al.  A Systematic Review of Neuroimaging for Cerebral Palsy , 2007, Journal of child neurology.

[9]  J. Carlin,et al.  Rates of cerebral palsy in Victoria, Australia, 1970 to 2004: has there been a change? , 2011, Developmental medicine and child neurology.

[10]  Peter Boesiger,et al.  Combining fMRI and DTI: A framework for exploring the limits of fMRI-guided DTI fiber tracking and for verifying DTI-based fiber tractography results , 2008, NeuroImage.

[11]  Uwe Klose,et al.  Reproducibility and consistency of evaluation techniques for HARDI data , 2009, Magnetic Resonance Materials in Physics, Biology and Medicine.

[12]  Dong Gyu Lee,et al.  Diffusion tensor imaging demonstrated radiologic differences between diplegic and quadriplegic cerebral palsy , 2012, Neuroscience Letters.

[13]  Kei Yamada,et al.  Fiber-Tracking Techniques Can Predict the Degree of Neurologic Impairment for Periventricular Leukomalacia , 2008, Pediatrics.

[14]  B. Banker,et al.  Periventricular leukomalacia of infancy. A form of neonatal anoxic encephalopathy. , 1962, Archives of neurology.

[15]  M. Kumar,et al.  Treatment-induced plasticity in cerebral palsy: a diffusion tensor imaging study. , 2008, Pediatric neurology.

[16]  P. Basser,et al.  MR diffusion tensor spectroscopy and imaging. , 1994, Biophysical journal.

[17]  Sung Ho Jang,et al.  Combined study of transcranial magnetic stimulation and diffusion tensor tractography for prediction of motor outcome in patients with corona radiata infarct. , 2011, Journal of rehabilitation medicine.

[18]  A. Hoon,et al.  Pathogenesis, neuroimaging and management in children with cerebral palsy born preterm. , 2010, Developmental disabilities research reviews.

[19]  Diffusion MRI in corticofugal fibers correlates with hand function in unilateral cerebral palsy , 2011, Neurology.

[20]  S. Jang,et al.  Diffusion tensor tractography can predict hemiparesis in infants with high risk factors , 2009, Neuroscience Letters.

[21]  P. Basser,et al.  Toward a quantitative assessment of diffusion anisotropy , 1996, Magnetic resonance in medicine.

[22]  Eung Yeop Kim,et al.  Motor pathway injury in patients with periventricular leucomalacia and spastic diplegia. , 2011, Brain : a journal of neurology.

[23]  Esben Meulengracht Flachs,et al.  Attentional and executive impairments in children with spastic cerebral palsy , 2010, Developmental medicine and child neurology.

[24]  Daniel Rueckert,et al.  Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data , 2006, NeuroImage.

[25]  S. Mori,et al.  Athetotic and spastic cerebral palsy: anatomic characterization based on diffusion-tensor imaging. , 2011, Radiology.

[26]  P. Basser,et al.  Water Diffusion Changes in Wallerian Degeneration and Their Dependence on White Matter Architecture , 2000 .

[27]  S. Lo,et al.  Improving quality of life of children with cerebral palsy: a systematic review of clinical trials. , 2012, Child: care, health and development.

[28]  M. Moseley,et al.  Diffusion tensor brain imaging findings at term-equivalent age may predict neurologic abnormalities in low birth weight preterm infants. , 2003, AJNR. American journal of neuroradiology.

[29]  Derek K. Jones Challenges and limitations of quantifying brain connectivity in vivo with diffusion MRI , 2010 .

[30]  G. Cosnard,et al.  Corticospinal Dysgenesis and Upper-Limb Deficits in Congenital Hemiplegia: A Diffusion Tensor Imaging Study , 2007, Pediatrics.

[31]  Ingeborg Krägeloh-Mann,et al.  Cerebral palsy update , 2009, Brain and Development.

[32]  E. Stejskal Use of Spin Echoes in a Pulsed Magnetic‐Field Gradient to Study Anisotropic, Restricted Diffusion and Flow , 1965 .

[33]  Michael I. Miller,et al.  Atlas-based analysis of neurodevelopment from infancy to adulthood using diffusion tensor imaging and applications for automated abnormality detection , 2010, NeuroImage.

[34]  G. Molenaers,et al.  Quantitative diffusion tensor imaging in cerebral palsy due to periventricular white matter injury. , 2005, Brain : a journal of neurology.

[35]  P C M van Zijl,et al.  Diffusion Tensor Imaging in Children with Periventricular Leukomalacia: Variability of Injuries to White Matter Tracts , 2007, American Journal of Neuroradiology.

[36]  S. Mori,et al.  Principles of Diffusion Tensor Imaging and Its Applications to Basic Neuroscience Research , 2006, Neuron.

[37]  G. Pearlson,et al.  In vivo visualization of human neural pathways by magnetic resonance imaging , 2000, Annals of neurology.

[38]  Stephen E. Rose,et al.  MRI Structural Connectivity, Disruption of Primary Sensorimotor Pathways, and Hand Function in Cerebral Palsy , 2011, Brain Connect..

[39]  A. Bastian,et al.  Sensory and motor deficits in children with cerebral palsy born preterm correlate with diffusion tensor imaging abnormalities in thalamocortical pathways , 2009, Developmental medicine and child neurology.

[40]  Meritxell Bach Cuadra,et al.  A review of atlas-based segmentation for magnetic resonance brain images , 2011, Comput. Methods Programs Biomed..

[41]  A. Eliasson,et al.  Development of the Assisting Hand Assessment: A Rasch-built Measure intended for Children with Unilateral Upper Limb Impairments , 2003 .

[42]  I. Krägeloh-Mann,et al.  The role of magnetic resonance imaging in elucidating the pathogenesis of cerebral palsy: a systematic review , 2007, Developmental medicine and child neurology.

[43]  S. Yoshida,et al.  Quantitative diffusion tensor tractography of the motor and sensory tract in children with cerebral palsy , 2010, Developmental medicine and child neurology.

[44]  Michael I. Miller,et al.  Quantitative analysis of brain pathology based on MRI and brain atlases—Applications for cerebral palsy , 2011, NeuroImage.

[45]  P. V. van Zijl,et al.  Three‐dimensional tracking of axonal projections in the brain by magnetic resonance imaging , 1999, Annals of neurology.

[46]  M. Kubicki,et al.  Anisotropy of transcallosal motor fibres indicates functional impairment in children with periventricular leukomalacia , 2011, Developmental medicine and child neurology.

[47]  Mark W. Woolrich,et al.  Probabilistic diffusion tractography with multiple fibre orientations: What can we gain? , 2007, NeuroImage.

[48]  Kai Eriksson,et al.  Executive Functions in Youth With Spastic Cerebral Palsy , 2011, Journal of child neurology.

[49]  P. Grant,et al.  Neuroimaging in CP : Issues in pathogenesis and diagnosis , 1997 .

[50]  M. Solaiyappan,et al.  Diffusion tensor imaging of periventricular leukomalacia shows affected sensory cortex white matter pathways , 2002, Neurology.

[51]  P. Basser,et al.  Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. , 1996, Journal of magnetic resonance. Series B.

[52]  I. Corouge,et al.  Analysis of brain white matter via fiber tract modeling , 2004, The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[53]  J. Thiran,et al.  Understanding diffusion MR imaging techniques: from scalar diffusion-weighted imaging to diffusion tensor imaging and beyond. , 2006, Radiographics : a review publication of the Radiological Society of North America, Inc.

[54]  W. Chang,et al.  Comparing quantitative tractography metrics of motor and sensory pathways in children with periventricular leukomalacia and different levels of gross motor function , 2012, Neuroradiology.

[55]  Wolfgang Grodd,et al.  Functional topography of early periventricular brain lesions in relation to cytoarchitectonic probabilistic maps , 2008, Brain and Language.

[56]  B. Dan,et al.  A report: the definition and classification of cerebral palsy April 2006 , 2007, Developmental medicine and child neurology. Supplement.

[57]  Rakesh K. Gupta,et al.  Correlation of quantitative sensorimotor tractography with clinical grade of cerebral palsy , 2010, Neuroradiology.

[58]  N. Makris,et al.  High angular resolution diffusion imaging reveals intravoxel white matter fiber heterogeneity , 2002, Magnetic resonance in medicine.

[59]  D. Cadman,et al.  THE GROSS MOTOR FUNCTION MEASURE: A MEANS TO EVALUATE THE EFFECTS OF PHYSICAL THERAPY , 1989, Developmental medicine and child neurology.

[60]  Louise Bøttcher Children with Spastic Cerebral Palsy, Their Cognitive Functioning, and Social Participation: A Review , 2010, Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence.