Carbon dots for optical imaging in vivo.

It was found and recently reported that small carbon nanoparticles can be surface-passivated by organic or biomolecules to become strongly fluorescent. These fluorescent carbon nanoparticles, dubbed "carbon dots", can be successfully used for in vitro cell imaging with both one- and two-photon excitations, as already demonstrated in the literature. Here we report the first study using carbon dots for optical imaging in live mice. The results suggest that the carbon dots remain strongly fluorescent in vivo, which, coupled with their biocompatibility and nontoxic characteristics, might offer great potential for imaging and related biomedical applications.

[1]  Jing Yang,et al.  One-step synthesis of fluorescent carbon nanoparticles by laser irradiation , 2009 .

[2]  Vincent M. Rotello,et al.  Applications of Nanoparticles in Biology , 2008 .

[3]  Ya‐Ping Sun,et al.  Doped Carbon Nanoparticles as a New Platform for Highly Photoluminescent Dots. , 2008, The journal of physical chemistry. C, Nanomaterials and interfaces.

[4]  Dai-Wen Pang,et al.  Facile preparation of low cytotoxicity fluorescent carbon nanocrystals by electrooxidation of graphite. , 2008, Chemical communications.

[5]  B. Nemery,et al.  Acute Toxicity and Prothrombotic Effects of Quantum Dots: Impact of Surface Charge , 2008, Environmental health perspectives.

[6]  Ming-Hsien Tsai,et al.  Computational and ultrastructural toxicology of a nanoparticle, Quantum Dot 705, in mice. , 2008, Environmental science & technology.

[7]  Leaf Huang,et al.  Pharmacokinetics and biodistribution of nanoparticles. , 2008, Molecular pharmaceutics.

[8]  Robert Sinclair,et al.  Real-time intravital imaging of RGD-quantum dot binding to luminal endothelium in mouse tumor neovasculature. , 2008, Nano letters.

[9]  E. Giannelis,et al.  Surface functionalized carbogenic quantum dots. , 2008, Small.

[10]  M. Bawendi,et al.  Renal clearance of quantum dots , 2007, Nature Biotechnology.

[11]  Ya‐Ping Sun,et al.  Carbon dots for multiphoton bioimaging. , 2007, Journal of the American Chemical Society.

[12]  C. Mao,et al.  Fluorescent carbon nanoparticles derived from candle soot. , 2007, Angewandte Chemie.

[13]  R. Li,et al.  An electrochemical avenue to blue luminescent nanocrystals from multiwalled carbon nanotubes (MWCNTs). , 2007, Journal of the American Chemical Society.

[14]  Ya‐Ping Sun,et al.  Quantum-sized carbon dots for bright and colorful photoluminescence. , 2006, Journal of the American Chemical Society.

[15]  Ron C. Hardman.  A Toxicologic Review of Quantum Dots: Toxicity Depends on Physicochemical and Environmental Factors , 2005, Environmental health perspectives.

[16]  S. Gambhir,et al.  Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics , 2005, Science.

[17]  S. Nie,et al.  In vivo cancer targeting and imaging with semiconductor quantum dots , 2004, Nature Biotechnology.

[18]  T. Mihaljevic,et al.  Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping , 2004, Nature Biotechnology.

[19]  S. Nie,et al.  Quantum dot bioconjugates for ultrasensitive nonisotopic detection. , 1998, Science.

[20]  A. Alivisatos.  Semiconductor Clusters, Nanocrystals, and Quantum Dots , 1996, Science.