Promoter polymorphisms of hepatic lipase gene influence HDL(2) but not HDL(3) in African American men: CARDIA study.

Hepatic lipase encoded by the hepatic lipase gene (LIPC) is involved in the metabolism of several lipoproteins. Four promoter polymorphisms in LIPC have been found to be in complete disequilibrium and associated with high density lipoprotein cholesterol (HDL-C) and apolipoprotein (apo)A-I levels in both white and black populations. We investigated the association between the promoter polymorphism and lipid profiles as well as anthropometric phenotypes in African American men in the Coronary Artery Risk Development in Young Adults study. We performed serial cross-sectional analyses and longitudinal analyses of lipids from 578 subjects in five examinations over 10 years of follow-up. Results showed that the allele frequency (0.52) in our black population was consistent with that reported in black subjects but much higher than that reported (approximately 0.2) in white populations. Analysis of covariance tests of the three genotypic means in each examination showed that the P values ranged from 0.01 to 0.08 for HDL-C (except P = 0.54 in the fourth examination), from 0.006 to 0.01 for HDL(2)-C, and from 0.06 to 0.07 for apoA-I. Mean HDL(3)-C levels were essentially identical among the three genotypes. Total cholesterol, low density lipoprotein cholesterol (LDL-C), triglycerides, and apoB, which are mainly involved in the very low density lipoprotein-LDL pathway, were not significantly different according to the promoter polymorphism, except for triglycerides in the third examination (P = 0.01). No significant association was found between anthropometric phenotypes and the LIPC polymorphism in any of five examinations. The change of the anthropometric variables was not significantly associated with genotypes. In conclusion, our results indicated that the LIPC promoter polymorphism has exclusive effects on HDL(2)-C but not HDL(3)-C levels.

[1]  B. Zinman,et al.  Variable association between genetic variation in the CYP7 gene promoter and plasma lipoproteins in three Canadian populations. , 1999, Atherosclerosis.

[2]  C. Bouchard,et al.  Race, visceral adipose tissue, plasma lipids, and lipoprotein lipase activity in men and women: the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) family study. , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[3]  P. Wilson,et al.  Association of the C-514T polymorphism in the hepatic lipase gene with variations in lipoprotein subclass profiles: The Framingham Offspring Study. , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[4]  S. Deeb,et al.  The C-514T polymorphism in the human hepatic lipase gene promoter diminishes its activity. , 2000, Journal of lipid research.

[5]  J. Gardin,et al.  Anthropometric and physiologic correlates of mitral valve prolapse in a biethnic cohort of young adults: the CARDIA study. , 1999, American heart journal.

[6]  J. Cigarroa,et al.  Hepatic lipase (LIPC) promoter polymorphism in men with coronary artery disease. Allele frequency and effects on hepatic lipase activity and plasma HDL-C concentrations. , 1999, Arteriosclerosis, thrombosis, and vascular biology.

[7]  E. Kass,et al.  Metabolic and genetic determinants of HDL metabolism and hepatic lipase activity in normolipidemic females. , 1999, Journal of lipid research.

[8]  L. Almasy,et al.  Human pedigree-based quantitative-trait-locus mapping: localization of two genes influencing HDL-cholesterol metabolism. , 1999, American journal of human genetics.

[9]  J. Hokanson,et al.  Evidence for a new pathophysiological mechanism for coronary artery disease regression: hepatic lipase-mediated changes in LDL density. , 1999, Circulation.

[10]  S. Grundy,et al.  Hepatic lipase activity influences high density lipoprotein subclass distribution in normotriglyceridemic men. Genetic and pharmacological evidence. , 1999, Journal of lipid research.

[11]  P. Talmud,et al.  The T allele of the hepatic lipase promoter variant C-480T is associated with increased fasting lipids and HDL and increased preprandial and postprandial LpCIII:B : European Atherosclerosis Research Study (EARS) II. , 1999, Arteriosclerosis, thrombosis, and vascular biology.

[12]  B. Zinman,et al.  Absence of association between genetic variation in the LIPC gene promoter and plasma lipoproteins in three Canadian populations. , 1999, Atherosclerosis.

[13]  J. Hokanson,et al.  Common variants in the promoter of the hepatic lipase gene are associated with lower levels of hepatic lipase activity, buoyant LDL, and higher HDL2 cholesterol. , 1998, Arteriosclerosis, thrombosis, and vascular biology.

[14]  S. Grundy,et al.  The -514 polymorphism in the hepatic lipase gene (LIPC) does not influence androgen-mediated stimulation of hepatic lipase activity. , 1998, Journal of lipid research.

[15]  J. Kobayashi,et al.  Lipoprotein lipase mass and activity in post‐heparin plasma from subjects with intra‐abdominal visceral fat accumulation , 1998, Clinical endocrinology.

[16]  M. Taskinen,et al.  Association of variation in hepatic lipase activity with promoter variation in the hepatic lipase gene. The LOCAT Study Invsestigators. , 1998, The Journal of clinical investigation.

[17]  S. Grundy,et al.  Hepatic lipase activity is lower in African American men than in white American men: effects of 5' flanking polymorphism in the hepatic lipase gene (LIPC). , 1998, Journal of lipid research.

[18]  J. Jukema,et al.  Common C-to-T substitution at position -480 of the hepatic lipase promoter associated with a lowered lipase activity in coronary artery disease patients. , 1997, Arteriosclerosis, thrombosis, and vascular biology.

[19]  L. Tiret,et al.  Hepatic lipase gene polymorphisms influence plasma HDL levels. Results from Finnish EARS participants. European Atherosclerosis Research Study. , 1997, Arteriosclerosis, thrombosis, and vascular biology.

[20]  M. Leppert,et al.  Recessive inheritance of obesity in familial non-insulin-dependent diabetes mellitus, and lack of linkage to nine candidate genes. , 1997, American journal of human genetics.

[21]  S. Grundy,et al.  A hepatic lipase (LIPC) allele associated with high plasma concentrations of high density lipoprotein cholesterol. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[22]  A. Folsom,et al.  Increase in fasting insulin and glucose over seven years with increasing weight and inactivity of young adults. The CARDIA Study. Coronary Artery Risk Development in Young Adults. , 1996, American journal of epidemiology.

[23]  D. Berryman,et al.  Genetics and molecular biology of hepatic lipase , 1996, Current opinion in lipidology.

[24]  D. Jacobs,et al.  Change and secular trends in physical activity patterns in young adults: a seven-year longitudinal follow-up in the Coronary Artery Risk Development in Young Adults Study (CARDIA). , 1996, American journal of epidemiology.

[25]  C. Packard,et al.  Relations between plasma lipids and postheparin plasma lipases and VLDL and LDL subfraction patterns in normolipemic men and women. , 1995, Arteriosclerosis, thrombosis, and vascular biology.

[26]  G Cutter,et al.  A study of the reliability and comparative validity of the cardia dietary history. , 1994, Ethnicity & disease.

[27]  S. Grundy,et al.  Variation at the hepatic lipase and apolipoprotein AI/CIII/AIV loci is a major cause of genetically determined variation in plasma HDL cholesterol levels. , 1994, The Journal of clinical investigation.

[28]  J. Hokanson,et al.  Effect of hepatic lipase on LDL in normal men and those with coronary artery disease. , 1993, Arteriosclerosis and thrombosis : a journal of vascular biology.

[29]  U. Garbin,et al.  High-density lipoprotein cholesterol concentrations and postheparin hepatic and lipoprotein lipases in obesity: relationships with plasma insulin levels. , 1993, Annals of nutrition & metabolism.

[30]  D. Jacobs,et al.  Meat consumption and its associations with other diet and health factors in young adults: the CARDIA study. , 1991, The American journal of clinical nutrition.

[31]  J. Kobayashi,et al.  Isolation and characterization of the human hepatic lipase gene. , 1990, The Journal of biological chemistry.

[32]  L. Chan,et al.  Structure of the human hepatic triglyceride lipase gene. , 1989, Biochemistry.

[33]  A. Dyer,et al.  Ethnic differences in blood pressure, pulse rate, and related characteristics in young adults. The CARDIA study. , 1989, Hypertension.

[34]  C. Bouchard,et al.  Role of hepatic-triglyceride lipase activity in the association between intra-abdominal fat and plasma HDL cholesterol in obese women. , 1989, Arteriosclerosis.

[35]  M. Emi,et al.  Genotyping and sequence analysis of apolipoprotein E isoforms. , 1988, Genomics.

[36]  D. Jacobs,et al.  Relationships of low density lipoprotein cholesterol with age and other factors: a cross-sectional analysis of the CARDIA study. , 1988, Annals of clinical research.

[37]  S B Hulley,et al.  CARDIA: study design, recruitment, and some characteristics of the examined subjects. , 1988, Journal of clinical epidemiology.

[38]  J. Albers,et al.  Comparison of commercial kits for apoprotein A-I and apoprotein B with standardized apoprotein A-I and B radioimmunoassays performed at the Northwest Lipid Research Center. , 1988, Journal of lipid research.

[39]  S. Zeger,et al.  Longitudinal data analysis using generalized linear models , 1986 .

[40]  K Y Liang,et al.  Longitudinal data analysis for discrete and continuous outcomes. , 1986, Biometrics.

[41]  Warnick Gr.  Enzymatic methods for quantification of lipoprotein lipids. , 1986 .

[42]  G. Warnick.  Enzymatic methods for quantification of lipoprotein lipids. , 1986, Methods in enzymology.

[43]  P. Bachorik,et al.  Precipitation methods for quantification of lipoproteins. , 1986, Methods in enzymology.

[44]  G. R. Warnick,et al.  Postheparin Plasma Triglyceride Lipases , 1985, Arteriosclerosis.

[45]  B. Howard,et al.  Characterization of lipase activities in obese Pima indians. Decreases with weight reduction. , 1982, The Journal of clinical investigation.

[46]  J. Albers,et al.  Dextran sulfate-Mg2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol. , 1982, Clinical chemistry.

[47]  G. L. Jensen,et al.  Triacylglycerol lipase, monoacylglycerol lipase and phospholipase activities of highly purified rat hepatic lipase. , 1982, Biochimica et biophysica acta.

[48]  E. Nikkilä,et al.  Evidence for the role of hepatic endothelial lipase in the metabolism of plasma high density lipoprotein2 in man. , 1980, Atherosclerosis.

[49]  D. Jacobs,et al.  Scoring systems for evaluating dietary pattern effect on serum cholesterol. , 1979, Preventive medicine.

[50]  W. Hazzard,et al.  Immunoassay of human plasma apolipoprotein B. , 1975, Metabolism: clinical and experimental.

[51]  R. Levy,et al.  Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. , 1972, Clinical chemistry.

[52]  A. Keys,et al.  Serum cholesterol response to changes in the diet: II. The effect of cholesterol in the diet. , 1965, Metabolism: clinical and experimental.