A Wireless Narrowband Imaging Chip for Capsule Endoscope

This paper presents a dual-mode capsule gastrointestinal endoscope device. An endoscope combined with a narrowband image (NBI), has been shown to be a superior diagnostic tool for early stage tissue neoplasms detection. Nevertheless, a wireless capsule endoscope with the narrowband imaging technology has not been presented in the market up to now. The narrowband image acquisition and power dissipation reduction are the main challenges of NBI capsule endoscope. In this paper, we present the first narrowband imaging capsule endoscope that can assist clinical doctors to effectively diagnose early gastrointestinal cancers, profited from our dedicated dual-mode complementary metal-oxide semiconductor (CMOS) sensor. The dedicated dual-mode CMOS sensor can offer white-light and narrowband images. Implementation results show that the proposed 512 × 512 CMOS sensor consumes only 2 mA at a 3-V power supply. The average current of the NBI capsule with an 8-Mb/s RF transmitter is nearly 7 ~ 8 mA that can continuously work for 6 ~ 8 h with two 1.5-V 80-mAh button batteries while the frame rate is 2 fps. Experimental results on backside mucosa of a human tongue and pig's small intestine showed that the wireless NBI capsule endoscope can significantly improve the image quality, compared with a commercial-of-the-shelf capsule endoscope for gastrointestinal tract diagnosis.

[1]  Yasushi Sano,et al.  Narrow band imaging: a new diagnostic approach to visualize angiogenesis in superficial neoplasia. , 2005, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[2]  Guolin Li,et al.  A Low-Power Digital IC Design Inside the Wireless Endoscopic Capsule , 2006, IEEE Journal of Solid-State Circuits.

[3]  Lan-Rong Dung,et al.  A wireless narrow-band imaging chip for capsule endoscope , 2009, 2009 IEEE Biomedical Circuits and Systems Conference.

[4]  Prateek Sharma,et al.  Narrow band imaging in Barrett’s esophagus , 2007, Expert review of gastroenterology & hepatology.

[5]  L. H. Lai,et al.  Obscure GI bleeding: is capsule endoscopy sufficient? , 2008, Gastrointestinal endoscopy.

[6]  Masahiro Yamaguchi,et al.  Appearance of enhanced tissue features in narrow-band endoscopic imaging. , 2004, Journal of biomedical optics.

[7]  Rastislav Lukac,et al.  Color filter arrays: design and performance analysis , 2005, IEEE Transactions on Consumer Electronics.

[8]  P. Swain,et al.  Wireless capsule endoscopy. , 2002, The Israel Medical Association journal : IMAJ.

[9]  R.W. Schafer,et al.  Demosaicking: color filter array interpolation , 2005, IEEE Signal Processing Magazine.

[10]  Victoria Porter,et al.  Negative capsule endoscopy in patients with obscure GI bleeding predicts low rebleeding rates. , 2008, Gastrointestinal endoscopy.

[11]  Lan-Rong Dung,et al.  A cardinal image compressor for capsule endoscope , 2006, 2006 IEEE Biomedical Circuits and Systems Conference.

[12]  Zhihua Wang,et al.  A Wireless Capsule Endoscope System With Low-Power Controlling and Processing ASIC , 2009, IEEE Transactions on Biomedical Circuits and Systems.

[13]  Masahiro Yamaguchi,et al.  Endoscopic Observation of Tissue by Narrowband Illumination , 2003 .

[14]  K. Gono,et al.  Multifunctional Endoscopic Imaging System for Support of Early Cancer Diagnosis , 2008, IEEE Journal of Selected Topics in Quantum Electronics.

[15]  Lan-Rong Dung,et al.  A modified H.264 intra-frame video encoder for capsule endoscope , 2008, 2008 IEEE Biomedical Circuits and Systems Conference.