Irreversible Electroporation

Irreversible electroporation (IRE) is a predominantly nonthermal ablative technology that uses high-voltage, low-energy DC current pulses to induce cell death. Thermal ablative technologies such as radiofrequency ablation, microwave ablation, and cryoablation have several applications in oncology but have limitations that have been established. IRE has shown promise to overcome some of these limitations. This article reviews the basics of the technology, patient selection, clinical applications, practical pointers, and the published data.

[1]  S. Solomon,et al.  Percutaneous ablation of peribiliary tumors with irreversible electroporation. , 2014, Journal of vascular and interventional radiology : JVIR.

[2]  Boris Rubinsky,et al.  In vivo results of a new focal tissue ablation technique: irreversible electroporation , 2006, IEEE Transactions on Biomedical Engineering.

[3]  H. Ahmed,et al.  INITIAL ASSESSMENT OF SAFETY AND CLINICAL FEASIBILITY OF IRREVERSIBLE ELECTROPORATION IN THE FOCAL TREATMENT OF PROSTATE CANCER , 2014, Prostate Cancer and Prostatic Disease.

[4]  G. Kazemier,et al.  Ablation of colorectal liver metastases by irreversible electroporation: results of the COLDFIRE-I ablate-and-resect study , 2014, European Radiology.

[5]  Vic Velanovich,et al.  Irreversible Electroporation in Locally Advanced Pancreatic Cancer: Potential Improved Overall Survival , 2013, Annals of Surgical Oncology.

[6]  C. Bassi,et al.  Feasibility and safety of radiofrequency ablation for locally advanced pancreatic cancer , 2010, The British journal of surgery.

[7]  Helen Kavnoudias,et al.  Investigation of the safety of irreversible electroporation in humans. , 2011, Journal of vascular and interventional radiology : JVIR.

[8]  Boris Rubinsky,et al.  Irreversible Electroporation: Implications for Prostate Ablation , 2007, Technology in cancer research & treatment.

[9]  A. Jemal,et al.  Global Cancer Statistics , 2011 .

[10]  Yuman Fong,et al.  Ablation of perivascular hepatic malignant tumors with irreversible electroporation. , 2012, Journal of the American College of Surgeons.

[11]  Boris Rubinsky,et al.  Irreversible Electroporation: A New Ablation Modality — Clinical Implications , 2007, Technology in cancer research & treatment.

[12]  N. Michalopoulos,et al.  High operative risk of cool‐tip radiofrequency ablation for unresectable pancreatic head cancer. John S, Anastasios D, Nikolaos M, Spiros K, Archodia V, Athanasios R, Athina C. 2007. J Surg Oncol 96: 89–90 , 2008, Journal of surgical oncology.

[13]  Stephen T Kee,et al.  Advanced hepatic ablation technique for creating complete cell death: irreversible electroporation. , 2010, Radiology.

[14]  G. Narayanan,et al.  Vessel Patency Post Irreversible Electroporation , 2014, CardioVascular and Interventional Radiology.

[15]  Boris Rubinsky,et al.  Cancer Cells Ablation with Irreversible Electroporation , 2005, Technology in cancer research & treatment.

[16]  Boris Rubinsky,et al.  Irreversible Electroporation in Medicine , 2007, Technology in cancer research & treatment.

[17]  H. Kourie,et al.  Optimum chemotherapy in the management of metastatic pancreatic cancer. , 2014, World journal of gastroenterology.