An Overview of Analeptic Applications of Omega-3 Fatty Acids

This article is an examination of the Analeptic Applications of Omega-3. The scientific development and subsequent clinical applications of Omega-3 in Healthcare continue to influence researchers all over the globe today. This article examines the research done and published by researchers and scientists. Consideration of current trends and data in scientific queries and demonstrates further aspects of the applications of Omega-3 on various health backgrounds, including. Cardiovascular Health: The study addresses the comparison of Omega-3 and Omega-6 in cardiovascular diseases. Higher intake of dietary Omega-3 helps activation, inhibition, and alteration of metabolic and signaling pathways which is associated with better cardiovascular health, while Omega-6 decreases the risk of coronary heart diseases and cardiovascular disease mortality. Immunology: Omega-3 Polyunsaturated Fatty Acids (PUFAs) have been found to show an anti-inflammatory effect in the body by downregulating the activation of various immune cells. They regulate immunological functions via eicosanoids and resolvins which are anti-inflammatory. External supplementation can reduce chronic and acute inflammation as well as reduce the chances of graft rejection. The regulatory effect is shown by modifying gene expression and/or signal transduction in human cells. They are also involved in altering the membrane composition of Fatty Acids(FA) and as a result, they affect the lipid raft structure and also membrane trafficking. Joint Health: The study shows the effects of omega-3 and other fatty acid consumption in Rheumatoid Arthritis(RA), bone marrow lesions, and knee cartilage lesions. It notes the interrelations between synovitis, plasma levels of Omega-3 and Omega-6 PUFAs in OsteoArthritis (OA) patients along with risk factors for OA, which could help consider liable treatments for improvement of OA. The study highlights the importance of the Omega-6:Omega-3 PUFA ratio and clinical and functional outcome measures which can help us in better understanding the role of PUFAs and possible treatments for people with knee osteoarthritis while showing the effect of Omega-3 fatty acids on muscle health in RA. Skin Disorders: Fish oils rich in PUFAs are reported to improve several inflammatory disorders, including rheumatoid arthritis and psoriasis. They have also been broadly reported as a potential supplement to ameliorate the severity of some skin disorders such as photoaging, skin cancer, allergy, dermatitis, cutaneous wounds, and melanogenesis. The significance of omega-3 in skin structure was proved by describing a syndrome caused by stringent fat reduction in the diet that leads to erythema with scaling, hair loss, itching, and increased water loss.

[1]  M. Rozalski,et al.  Effects of Omega-3 Polyunsaturated Fatty Acids and Their Metabolites on Haemostasis—Current Perspectives in Cardiovascular Disease , 2021, International journal of molecular sciences.

[2]  R. Donkin,et al.  Long Chain Omega-3 Polyunsaturated Fatty Acids Improve Vascular Stiffness in Abdominal Aortic Aneurysm: A Randomized Controlled Trial , 2020, Nutrients.

[3]  Sang Hoon Lee,et al.  Resolvin D3 controls mouse and human TRPV1-positive neurons and preclinical progression of psoriasis , 2020, Theranostics.

[4]  A. Franco‐Cereceda,et al.  Omega-3 Polyunsaturated Fatty Acids Decrease Aortic Valve Disease Through the Resolvin E1 and ChemR23 Axis , 2020, Circulation.

[5]  I. Kostoglou-Athanassiou,et al.  The Effect of Omega-3 Fatty Acids on Rheumatoid Arthritis , 2020, Mediterranean journal of rheumatology.

[6]  M. Sapijaszko,et al.  The Potential Uses of Omega-3 Fatty Acids in Dermatology: A Review , 2020, Journal of cutaneous medicine and surgery.

[7]  Deepak L. Bhatt,et al.  Emerging Mechanisms of Cardiovascular Protection for the Omega-3 Fatty Acid Eicosapentaenoic Acid , 2020, Arteriosclerosis, thrombosis, and vascular biology.

[8]  B. Marinovic,et al.  Omega-3 Versus Omega-6 Polyunsaturated Fatty Acids in the Prevention and Treatment of Inflammatory Skin Diseases , 2020, International journal of molecular sciences.

[9]  F. Capel,et al.  Could Omega 3 Fatty Acids Preserve Muscle Health in Rheumatoid Arthritis? , 2020, Nutrients.

[10]  L. Kanim,et al.  Omega-3 Fatty Acid Supplementation Reduces Intervertebral Disc Degeneration , 2019, Medical science monitor : international medical journal of experimental and clinical research.

[11]  M. Johansson,et al.  Effects of Omega-3 Fatty Acids on Immune Cells , 2019, International journal of molecular sciences.

[12]  S. Pham,et al.  Cardiovascular, electrophysiologic, and hematologic effects of omega-3 fatty acids beyond reducing hypertriglyceridemia: as it pertains to the recently published REDUCE-IT trial , 2019, Cardiovascular Diabetology.

[13]  L. Ilag Are Long-Chain Polyunsaturated Fatty Acids the Link between the Immune System and the Microbiome towards Modulating Cancer? , 2018, Medicines.

[14]  Pei-Wen Wang,et al.  Cosmetic and Therapeutic Applications of Fish Oil’s Fatty Acids on the Skin , 2018, Marine drugs.

[15]  R. Fillingim,et al.  Omega-6: Omega-3 PUFA Ratio, Pain, Functioning, and Distress in Adults With Knee Pain , 2017, The Clinical journal of pain.

[16]  H. Kusuhara,et al.  Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation , 2017, Nature Medicine.

[17]  I. Dichi,et al.  n-3 polyunsaturated fatty acids supplementation in psoriasis: a review , 2017, Nutrire.

[18]  Xiaoliang Wang,et al.  Effects of a purified krill oil phospholipid rich in long-chain omega-3 fatty acids on cardiovascular disease risk factors in non-human primates with naturally occurring diabetes type-2 and dyslipidemia , 2017, Lipids in Health and Disease.

[19]  R. Chapkin,et al.  Omega-3 fatty acids, lipid rafts, and T cell signaling. , 2016, European journal of pharmacology.

[20]  J. Fialkow Omega-3 Fatty Acid Formulations in Cardiovascular Disease: Dietary Supplements are Not Substitutes for Prescription Products , 2016, American Journal of Cardiovascular Drugs.

[21]  V. Gudnason,et al.  Higher Plasma Phospholipid n-3 PUFAs, but Lower n-6 PUFAs, Are Associated with Lower Pulse Wave Velocity among Older Adults. , 2015, The Journal of nutrition.

[22]  M. Moreno-Aliaga,et al.  An update on the role of omega-3 fatty acids on inflammatory and degenerative diseases , 2015, Journal of Physiology and Biochemistry.

[23]  S. Datta,et al.  Effects of Parental Omega-3 Fatty Acid Intake on Offspring Microbiome and Immunity , 2014, PloS one.

[24]  L. Cleland,et al.  Osteoarthritis: Omega-3 fatty acids and synovitis in osteoarthritic knees , 2012, Nature Reviews Rheumatology.

[25]  J. Geleijnse,et al.  Fish oil and omega-3 fatty acids in cardiovascular disease: do they really work? , 2012, European heart journal.

[26]  V. Yadav,et al.  The Effects of Omega-3 Fatty Acids on Matrix Metalloproteinase-9 Production and Cell Migration in Human Immune Cells: Implications for Multiple Sclerosis , 2011, Autoimmune diseases.

[27]  L. Rhodes,et al.  Omega‐3 polyunsaturated fatty acids: photoprotective macronutrients , 2011, Experimental dermatology.

[28]  J. Reichrath,et al.  Peroxisome proliferator-activated receptors (PPARs) in dermatology: Challenge and promise. , 2011, Dermato-endocrinology.

[29]  D. Kelley,et al.  Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids. , 2010, The Journal of nutritional biochemistry.

[30]  J. Harwood,et al.  Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis. , 2009, Osteoarthritis and cartilage.

[31]  P. Calder The relationship between the fatty acid composition of immune cells and their function. , 2008, Prostaglandins, leukotrienes, and essential fatty acids.

[32]  D. English,et al.  Effect of fatty acids on bone marrow lesions and knee cartilage in healthy, middle-aged subjects without clinical knee osteoarthritis. , 2008, Osteoarthritis and cartilage.

[33]  R. Goldberg,et al.  A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain , 2007, Pain.

[34]  P. Calder,et al.  Polyunsaturated fatty acids, inflammation, and immunity , 2001, Lipids.

[35]  K. Mayer,et al.  Regulatory potential of n-3 fatty acids in immunological and inflammatory processes , 2002, British Journal of Nutrition.

[36]  P. Calder Immunoregulatory and anti-inflammatory effects of n-3 polyunsaturated fatty acids. , 1998, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[37]  L. Rhodes,et al.  Dietary fish oil reduces basal and ultraviolet B-generated PGE2 levels in skin and increases the threshold to provocation of polymorphic light eruption. , 1995, The Journal of investigative dermatology.

[38]  P. Geusens,et al.  Long-term effect of omega-3 fatty acid supplementation in active rheumatoid arthritis. A 12-month, double-blind, controlled study. , 1994, Arthritis and rheumatism.