Investigation of 70SiO2-15CaO-10P2O5-5Na2O Glass Composition for Bone Regeneration Applications

Glass with the composition 70SiO 2 -15CaO -10P 2 O 5 -5Na 2 O has been prepared by using sol gel technique. Bioactive behavior of the glass sample has been checked by in vitro study using TRIS simulated body fluid. Bioactive properties of the sample has been analyzed by using XRD, Raman, FE-SEM, EDX and Brunauer Emmett Teller studies. pH study has been conducted to check the non- acidic nature of the glass sample. Drug delivery behavior of the sample has been estimated by using gentamicin as an antibiotic. Reported sample has been found to be potential candidate for bone regeneration applications.

[1]  Julian R Jones,et al.  Review of bioactive glass: from Hench to hybrids. , 2013, Acta biomaterialia.

[2]  Xiaofen Li,et al.  Synthesis of hierarchically porous bioactive glasses using natural plants as template for bone tissue regeneration , 2012, Journal of Sol-Gel Science and Technology.

[3]  M. H. Fernandes,et al.  In vitro bioactivity of 70 wt.% SiO2 — 30 wt.% CaO sol-gel glass, doped with 1, 3 and 5 wt.% NbF5 , 2012 .

[4]  D. Qiu,et al.  Bioactive glass sol-gel foam scaffolds: Evolution of nanoporosity during processing and in situ monitoring of apatite layer formation using small- and wide-angle X-ray scattering. , 2009, Journal of biomedical materials research. Part A.

[5]  A. Tilocca Structural models of bioactive glasses from molecular dynamics simulations , 2009, Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[6]  Jianlin Shi,et al.  One-pot synthesis of magnetic and mesoporous bioactive glass composites and their sustained drug release property , 2008 .

[7]  Sarit B. Bhaduri,et al.  Using a synthetic body fluid (SBF) solution of 27 mM HCO3− to make bone substitutes more osteointegrative , 2008 .

[8]  Masakazu Kawashita,et al.  Novel bioactive materials with different mechanical properties. , 2003, Biomaterials.

[9]  Eduardo Saiz,et al.  Bioactive glass coatings for orthopedic metallic implants , 2003 .

[10]  C. Rey,et al.  MicroRaman Spectral Study of the PO4 and CO3 Vibrational Modes in Synthetic and Biological Apatites , 1998, Calcified Tissue International.

[11]  A Pizzoferrato,et al.  In vitro evaluation of cell/biomaterial interaction by MTT assay. , 1993, Biomaterials.

[12]  L L Hench,et al.  Compositional dependence of the formation of calcium phosphate films on bioglass. , 1980, Journal of biomedical materials research.

[13]  E. Barrett,et al.  (CONTRIBUTION FROM THE MULTIPLE FELLOWSHIP OF BAUGH AND SONS COMPANY, MELLOX INSTITUTE) The Determination of Pore Volume and Area Distributions in Porous Substances. I. Computations from Nitrogen Isotherms , 1951 .