Experimental studies of pedunculopontine functions: are they motor, sensory or integrative?

The pedunculopontine tegmental nucleus (PPTg) is involved in Parkinson's disease and has become a therapeutic target. However, its normal functions are uncertain: are they motor, sensory or integrative? This position paper reviews PPTg structure and considers experiments designed to understand its behavioural functions. The PPTg is part of the corticostriatal architecture and, consistent with this, a core deficit following lesion is the inability to properly establish action-outcome associations. Understanding normal PPTg structure and function will provide insight into the role it has in Parkinson's disease and related disorders, and will benefit the development of surgical treatments aimed here.

[1]  M. Inase,et al.  Excitotoxic lesions of the pedunculopontine tegmental nucleus produce contralateral hemiparkinsonism in the monkey , 1997, Neuroscience Letters.

[2]  P. Redgrave,et al.  The basal ganglia: a vertebrate solution to the selection problem? , 1999, Neuroscience.

[3]  R. G. Robertson,et al.  Neural mechanisms underlying parkinsonian symptoms based upon regional uptake of 2-deoxyglucose in monkeys exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine , 1989, Neuroscience.

[4]  S. W. Ranson,et al.  The Anatomy of the Nervous System , 2010 .

[5]  A. Bass,et al.  Cholinergic neurons in the brain of a teleost fish (Porichthys notatus) located with a monoclonal antibody to choline acetyltransferase , 1988, The Journal of comparative neurology.

[6]  J. Olszewski,et al.  Cytoarchitecture of the Human Brain Stem , 1955 .

[7]  P. Winn,et al.  Examination of the role of the pedunculopontine tegmental nucleus in radial maze tasks with or without a delay , 2002, Neuroscience.

[8]  B. Kretschmer,et al.  Effects of ibotenate pedunculopontine tegmental nucleus lesions on exploratory behaviour in the open field , 2004, Behavioural Brain Research.

[9]  Stan B. Floresco,et al.  Thalamic–Cortical–Striatal Circuitry Subserves Working Memory during Delayed Responding on a Radial Arm Maze , 1999, The Journal of Neuroscience.

[10]  S. Walker,et al.  An assessment of the contributions of the pedunculopontine tegmental and cuneiform nuclei to anxiety and neophobia , 2007, Neuroscience.

[11]  N. Swerdlow,et al.  Lesions of the dorsomedial nucleus of the thalamus, medial prefrontal cortex and pedunculopontine nucleus: effects on locomotor activity mediated by nucleus accumbens-ventral pallidal circuitry , 1987, Brain Research.

[12]  B. Balleine,et al.  The role of the dorsomedial striatum in instrumental conditioning , 2005, The European journal of neuroscience.

[13]  M. Olmstead,et al.  Lesions of the pedunculopontine tegmental nucleus block drug-induced reinforcement but not amphetamine-induced locomotion , 1994, Brain Research.

[14]  P. Winn,et al.  An investigation into the role of the pedunculopontine tegmental nucleus in the mediation of locomotion and orofacial stereotypy induced by d-amphetamine and apomorphine in the rat , 1994, Neuroscience.

[15]  R. Miall,et al.  Pedunculopontine nucleus stimulation improves akinesia in a Parkinsonian monkey , 2004, Neuroreport.

[16]  Andreas Heinz,et al.  Severity of nicotine dependence modulates cue-induced brain activity in regions involved in motor preparation and imagery , 2006, Psychopharmacology.

[17]  Peter Redgrave,et al.  Layered Control Architectures in Robots and Vertebrates , 1999, Adapt. Behav..

[18]  J. Paul Bolam,et al.  Pedunculopontine nucleus and basal ganglia: distant relatives or part of the same family? , 2004, Trends in Neurosciences.

[19]  M. Kaste,et al.  MRI correlates of executive dysfunction in patients with ischaemic stroke , 2003, European journal of neurology.

[20]  A. Grace,et al.  The laterodorsal tegmentum is essential for burst firing of ventral tegmental area dopamine neurons. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[21]  W. Pan,et al.  Pedunculopontine Tegmental Nucleus Controls Conditioned Responses of Midbrain Dopamine Neurons in Behaving Rats , 2005, The Journal of Neuroscience.

[22]  P. Winn,et al.  Intravenous self‐administration of nicotine is altered by lesions of the posterior, but not anterior, pedunculopontine tegmental nucleus , 2006, The European journal of neuroscience.

[23]  Ludvic Zrinzo,et al.  The pedunculopontine and peripeduncular nuclei: a tale of two structures. , 2007, Brain : a journal of neurology.

[24]  Reply: The peripeduncular and pedunculopontine nuclei: a putative dispute not discouraging the effort to define a clinically relevant target , 2007 .

[25]  P. Stanzione,et al.  Implantation of human pedunculopontine nucleus: a safe and clinically relevant target in Parkinson's disease , 2005, Neuroreport.

[26]  P. J. Brasted,et al.  The effect of excitotoxic lesions of the pedunculopontine tegmental nucleus on performance of a progressive ratio schedule of reinforcement , 2002, Neuroscience.

[27]  C. Blaha,et al.  Pedunculopontine tegmental stimulation evokes striatal dopamine efflux by activation of acetylcholine and glutamate receptors in the midbrain and pons of the rat , 2003, The European journal of neuroscience.

[28]  J. Obeso,et al.  Bilateral deep brain stimulation of the subthalamic nucleus in Parkinson's disease. , 2000, Neurology.

[29]  H. Condé,et al.  The role of the pedunculopontine tegmental nucleus in relation to conditioned motor performance in the cat I. Context-dependent and reinforcement-related single unit activity , 1998, Experimental Brain Research.

[30]  P. Winn,et al.  Outflow from the nucleus accumbens to the pedunculopontine tegmental nucleus: A dissociation between locomotor activity and the acquisition of responding for conditioned reinforcement stimulated by d-amphetamine , 1994, Neuroscience.

[31]  P. Winn.  How best to consider the structure and function of the pedunculopontine tegmental nucleus: Evidence from animal studies , 2006, Journal of the Neurological Sciences.

[32]  J. Stein,et al.  The role of the pedunculopontine region in basal-ganglia mechanisms of akinesia , 1999, Experimental Brain Research.

[33]  P. Winn,et al.  Fusion of diphtheria toxin and urotensin II produces a neurotoxin selective for cholinergic neurons in the rat mesopontine tegmentum , 2007, Journal of neurochemistry.

[34]  A. Phillips,et al.  An examination of d-amphetamine self-administration in pedunculopontine tegmental nucleus-lesioned rats , 2004, Neuroscience.

[35]  V. Brown,et al.  On the relationships between the striatum and the pedunculopontine tegmental nucleus. , 1997, Critical reviews in neurobiology.

[36]  Douglas L. Jones,et al.  From motivation to action: Functional interface between the limbic system and the motor system , 1980, Progress in Neurobiology.

[37]  S. Gill,et al.  Bilateral deep brain stimulation of the pedunculopontine nucleus for Parkinson's disease , 2005, Neuroreport.

[38]  H. Braak,et al.  Staging of brain pathology related to sporadic Parkinson’s disease , 2003, Neurobiology of Aging.

[39]  P. Pahapill,et al.  The pedunculopontine nucleus and Parkinson's disease. , 2000, Brain : a journal of neurology.

[40]  E. Hennevin,et al.  Lesions of the pedunculopontine tegmental nucleus reduce paradoxical sleep (PS) propensity: evidence from a short‐term PS deprivation study in rats , 2001, The European journal of neuroscience.

[41]  M. Steriade.  Grouping of brain rhythms in corticothalamic systems , 2006, Neuroscience.