Trading the micro-world of combinatorial complexity for the macro-world of protein interaction domains.

[1]  Julio Saez-Rodriguez,et al.  A domain-oriented approach to the reduction of combinatorial complexity in signal transduction networks , 2006, BMC Bioinformatics.

[2]  B. Kholodenko,et al.  Signaling through receptors and scaffolds: independent interactions reduce combinatorial complexity. , 2005, Biophysical journal.

[3]  William S. Hlavacek,et al.  BioNetGen: software for rule-based modeling of signal transduction based on the interactions of molecular domains , 2004, Bioinform..

[4]  M. White,et al.  The IRS-signalling system: A network of docking proteins that mediate insulin action , 1998, Molecular and Cellular Biochemistry.

[5]  James R Faeder,et al.  The complexity of complexes in signal transduction , 2003, Biotechnology and bioengineering.

[6]  T. Hirano,et al.  The role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptors , 2003, Cancer science.

[7]  L. Kuo,et al.  Structure of apo, unactivated insulin-like growth factor-1 receptor kinase at 1.5 A resolution. , 2003, Acta crystallographica. Section D, Biological crystallography.

[8]  E. Nagata,et al.  Akt as a mediator of cell death , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[9]  S. Kimura,et al.  A computational model on the modulation of mitogen-activated protein kinase (MAPK) and Akt pathways in heregulin-induced ErbB signalling. , 2003, The Biochemical journal.

[10]  S. Shoelson,et al.  Two New Substrates in Insulin Signaling, IRS5/DOK4 and IRS6/DOK5* , 2003, Journal of Biological Chemistry.

[11]  T. Pawson,et al.  Assembly of Cell Regulatory Systems Through Protein Interaction Domains , 2003, Science.

[12]  W. S. Hlavacek,et al.  Investigation of Early Events in FcεRI-Mediated Signaling Using a Detailed Mathematical Model1 , 2003, The Journal of Immunology.

[13]  T. Hirano,et al.  Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2 , 2003, Oncogene.

[14]  James R Faeder,et al.  Investigation of early events in Fc epsilon RI-mediated signaling using a detailed mathematical model. , 2003, Journal of immunology.

[15]  Hiroaki Kitano,et al.  Next generation simulation tools: the Systems Biology Workbench and BioSPICE integration. , 2003, Omics : a journal of integrative biology.

[16]  C. Rao,et al.  Control, exploitation and tolerance of intracellular noise , 2002, Nature.

[17]  M. White,et al.  IRS proteins and the common path to diabetes. , 2002, American journal of physiology. Endocrinology and metabolism.

[18]  E. Gilles,et al.  Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors , 2002, Nature Biotechnology.

[19]  A. Saltiel,et al.  Insulin signaling pathways in time and space. , 2002, Trends in cell biology.

[20]  B. Kholodenko,et al.  Temperature dependence of the epidermal growth factor receptor signaling network can be accounted for by a kinetic model. , 2002, Biochemistry.

[21]  Nicolas Le Novère,et al.  STOCHSIM: modelling of stochastic biomolecular processes , 2001, Bioinform..

[22]  A. J. Ablooglu,et al.  Activation of the insulin receptor's kinase domain changes the rate-determining step of substrate phosphorylation. , 2001, Biochemistry.

[23]  D. Lauffenburger,et al.  A Computational Study of Feedback Effects on Signal Dynamics in a Mitogen‐Activated Protein Kinase (MAPK) Pathway Model , 2001, Biotechnology progress.

[24]  Dennis Bray,et al.  Molecular model of a lattice of signalling proteins involved in bacterial chemotaxis , 2000, Nature Cell Biology.

[25]  D. Lauffenburger,et al.  Mathematical modeling of epidermal growth factor receptor signaling through the phospholipase C pathway: mechanistic insights and predictions for molecular interventions. , 2000, Biotechnology and bioengineering.

[26]  J. Schlessinger.  Cell Signaling by Receptor Tyrosine Kinases , 2000, Cell.

[27]  D. Müller-Wieland,et al.  Identification of major tyrosine phosphorylation sites in the human insulin receptor substrate Gab-1 by insulin receptor kinase in vitro. , 2000, Biochemistry.

[28]  Jehoshua Bruck,et al.  Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[29]  Joseph Schlessinger,et al.  A Novel Positive Feedback Loop Mediated by the Docking Protein Gab1 and Phosphatidylinositol 3-Kinase in Epidermal Growth Factor Receptor Signaling , 2000, Molecular and Cellular Biology.

[30]  T. Hunter,et al.  Signaling—2000 and Beyond , 2000, Cell.

[31]  C. Yip,et al.  Mechanism of transmembrane signaling: insulin binding and the insulin receptor. , 2000, Biochemistry.

[32]  B. Kholodenko,et al.  Quantification of Short Term Signaling by the Epidermal Growth Factor Receptor* , 1999, The Journal of Biological Chemistry.

[33]  Alan Wells,et al.  Effect of Epidermal Growth Factor Receptor Internalization on Regulation of the Phospholipase C-γ1 Signaling Pathway* , 1999, The Journal of Biological Chemistry.

[34]  D A Lauffenburger,et al.  Effect of epidermal growth factor receptor internalization on regulation of the phospholipase C-gamma1 signaling pathway. , 1999, The Journal of biological chemistry.

[35]  M. Gold,et al.  The Gab1 Protein Is a Docking Site for Multiple Proteins Involved in Signaling by the B Cell Antigen Receptor* , 1998, The Journal of Biological Chemistry.

[36]  K. Siddle,et al.  Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. , 1998, The Biochemical journal.

[37]  B. Kholodenko,et al.  Control analysis of metabolic systems involving quasi-equilibrium reactions. , 1998, Biochimica et biophysica acta.

[38]  D. Bray,et al.  Signaling complexes: biophysical constraints on intracellular communication. , 1998, Annual review of biophysics and biomolecular structure.

[39]  C. J.,et al.  Predicting Temporal Fluctuations in an Intracellular Signalling Pathway , 1998 .

[40]  T. Pawson,et al.  Signaling through scaffold, anchoring, and adaptor proteins. , 1997, Science.

[41]  J. Blenis,et al.  YMXM motifs and signaling by an insulin receptor substrate 1 molecule without tyrosine phosphorylation sites , 1996, Molecular and cellular biology.

[42]  C. Roberts,et al.  Interaction between the Insulin Receptor and Its Downstream Effectors , 1996, The Journal of Biological Chemistry.

[43]  V. I. Arnol'd,et al.  Dynamical Systems V , 1994 .

[44]  V. Arnold.  Dynamical systems V. Bifurcation theory and catastrophe theory , 1994 .

[45]  J. Shafer,et al.  Evidence that insulin receptor from human placenta has a high affinity for only one molecule of insulin. , 1984, The Journal of biological chemistry.

[46]  N. K. Rozov,et al.  Differential Equations with Small Parameters and Relaxation Oscillations , 1980 .

[47]  D. Gillespie.  Exact Stochastic Simulation of Coupled Chemical Reactions , 1977 .

[48]  R Heinrich,et al.  Metabolic regulation and mathematical models. , 1977, Progress in biophysics and molecular biology.

[49]  Neil Fenichel.  Persistence and Smoothness of Invariant Manifolds for Flows , 1971 .