Simultaneous confidence bands for ratios of survival functions via empirical likelihood

We derive a simultaneous confidence band for the ratio of two survival functions based on independent right-censored data. Earlier authors have studied such bands for the difference of two survival functions, but the ratio provides a more appropriate comparison in some applications, e.g., in comparing two treatments in biomedical settings. Our approach is formulated in terms of empirical likelihood and allows us to avoid the use of simulation techniques that are often needed for Wald-type confidence bands. By the transformation-preserving property we also obtain confidence bands for the difference in the cumulative hazard functions. The approach is illustrated with a real data example.

[1]  H. J. Einmahl Con dence tubes for multiple quantile plotsvia empirical likelihoodJohn , 1998 .

[2]  Bing-Yi Jing,et al.  Two-sample empirical likelihood method , 1995 .

[3]  Jon A. Wellner,et al.  Confidence bands for a survival curve from censored data , 1980 .

[4]  D. Harrington,et al.  Counting Processes and Survival Analysis , 1991 .

[5]  Gang Li,et al.  On nonparametric likelihood ratio estimation of survival probabilities for censored data , 1995 .

[6]  C F Chung Wiener pack: a subroutine package for computing probabilities associated with Wiener and Brownian Bridge processes , 1987 .

[7]  Michael Parzen,et al.  Simultaneous Confidence Intervals for the Difference of Two Survival Functions , 1997 .

[8]  Myles Hollander,et al.  Likelihood Ratio-Based Confidence Bands for Survival Functions , 1997 .

[9]  Qin Yong,et al.  EMPIRICAL LIKELIHOOD RATIO CONFIDENCE INTERVALS FOR VARIOUS DIFFERENCES OF TWO POPULATIONS , 2000 .

[10]  A. Owen Empirical likelihood ratio confidence intervals for a single functional , 1988 .

[11]  William H. Press,et al.  Numerical Recipes in C, 2nd Edition , 1992 .

[12]  L J Wei,et al.  Nonparametric estimation for the difference or ratio of median failure times. , 1993, Biometrics.

[13]  Zhiliang Ying,et al.  A simple nonparametric estimator of the bivariate survival function under univariate censoring , 1993 .

[14]  A. Owen Empirical Likelihood Ratio Confidence Regions , 1990 .

[15]  S. Murphy Likelihood Ratio-Based Confidence Intervals in Survival Analysis , 1995 .

[16]  Niels Keiding,et al.  Statistical Models Based on Counting Processes , 1993 .

[17]  Yongsong Qin,et al.  Semi-parametric likelihood ratio confidence intervals for various differences of two populations , 1997 .

[18]  Kjell A. Doksum,et al.  Graphical comparison of cumulative hazards for two populations , 1989 .

[19]  Vijayan N. Nair,et al.  Confidence Bands for Survival Functions With Censored Data: A Comparative Study , 1984 .

[20]  J. Klein,et al.  Statistical Models Based On Counting Process , 1994 .

[21]  William H. Press,et al.  Numerical recipes in C , 2002 .

[22]  Jing Qin,et al.  Semi-empirical likelihood ratio confidence intervals for the difference of two sample means , 1994 .

[23]  DavidR . Thomas,et al.  Confidence Interval Estimation of Survival Probabilities for Censored Data , 1975 .