Short-term inhibition of peroxisome proliferator-activated receptor-γ coactivator-1α expression reverses diet-induced diabetes mellitus and hepatic steatosis in mice

[1]  A. Vercesi,et al.  Cold-induced PGC-1alpha expression modulates muscle glucose uptake through an insulin receptor/Akt-independent, AMPK-dependent pathway. , 2004, American journal of physiology. Endocrinology and metabolism.

[2]  J. Speakman Obesity: the integrated roles of environment and genetics. , 2004, The Journal of nutrition.

[3]  J. Horton,et al.  Molecular mediators of hepatic steatosis and liver injury. , 2004, The Journal of clinical investigation.

[4]  F. Krempler,et al.  Restoration of sterol-regulatory-element-binding protein-1c gene expression in HepG2 cells by peroxisome-proliferator-activated receptor-γ co-activator-1α , 2004 .

[5]  Marc Montminy,et al.  PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3 , 2004, Nature Medicine.

[6]  H. Sone,et al.  SREBP-1 Interacts with Hepatocyte Nuclear Factor-4α and Interferes with PGC-1 Recruitment to Suppress Hepatic Gluconeogenic Genes* , 2004, Journal of Biological Chemistry.

[7]  J. Flier Obesity Wars Molecular Progress Confronts an Expanding Epidemic , 2004, Cell.

[8]  Ianessa Morantte,et al.  CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-γ , 2003, Nature.

[9]  J. Carvalheira,et al.  Peroxisome proliferator-activated receptor γ coactivator-1-dependent uncoupling protein-2 expression in pancreatic islets of rats: a novel pathway for neural control of insulin secretion , 2003, Diabetologia.

[10]  L. Velloso,et al.  Cold Exposure Induces Tissue‐Specific Modulation of the Insulin‐Signalling Pathway in Rattus Norvegicus , 2003, The Journal of physiology.

[11]  U. Smith,et al.  Reduced expression of FOXC2 and brown adipogenic genes in human subjects with insulin resistance. , 2003, Obesity research.

[12]  M. Reitman,et al.  Liver Peroxisome Proliferator-activated Receptor γ Contributes to Hepatic Steatosis, Triglyceride Clearance, and Regulation of Body Fat Mass* , 2003, Journal of Biological Chemistry.

[13]  D. Langin,et al.  Acquirement of Brown Fat Cell Features by Human White Adipocytes* , 2003, Journal of Biological Chemistry.

[14]  M. Rossmeisl,et al.  Variation in type 2 diabetes--related traits in mouse strains susceptible to diet-induced obesity. , 2003, Diabetes.

[15]  L. Kozak,et al.  Dietary fat interacts with QTLs controlling induction of Pgc-1 alpha and Ucp1 during conversion of white to brown fat. , 2003, Physiological genomics.

[16]  P. Puigserver,et al.  Suppression of β Cell Energy Metabolism and Insulin Release by PGC-1α , 2003 .

[17]  Bruce M. Spiegelman,et al.  Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction , 2003, Nature.

[18]  P. Puigserver,et al.  Regulation of hepatic fasting response by PPARγ coactivator-1α (PGC-1): Requirement for hepatocyte nuclear factor 4α in gluconeogenesis , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[19]  U. Smith,et al.  Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance. , 2003, Biochemical and biophysical research communications.

[20]  P. Puigserver,et al.  Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. , 2003, Endocrine reviews.

[21]  T. Kadowaki,et al.  A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes , 2002, Diabetologia.

[22]  J. Shaw,et al.  Global and societal implications of the diabetes epidemic , 2001, Nature.

[23]  D. Moller,et al.  New drug targets for type 2 diabetes and the metabolic syndrome , 2001, Nature.

[24]  T. Hansen,et al.  Mutation analysis of peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus , 2001, Diabetologia.

[25]  Guillaume Adelmant,et al.  Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1 , 2001, Nature.

[26]  Marc Montminy,et al.  CREB regulates hepatic gluconeogenesis through the coactivator PGC-1 , 2001, Nature.

[27]  P. Puigserver,et al.  Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1 , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[28]  D. Porte,et al.  beta-cell dysfunction and failure in type 2 diabetes: potential mechanisms. , 2001, Diabetes.

[29]  N. Barzilai,et al.  Ability of insulin to modulate hepatic glucose production in aging rats is impaired by fat accumulation. , 2000, American journal of physiology. Endocrinology and metabolism.

[30]  Peirong Yang,et al.  Direct Binding and In Vivo Regulation of the Fission Yeast p21-Activated Kinase Shk1 by the SH3 Domain Protein Scd2 , 1999, Molecular and Cellular Biology.

[31]  V. Mootha,et al.  Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1 , 1999, Cell.

[32]  P. Puigserver,et al.  A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis , 1998, Cell.

[33]  D. Gauguier,et al.  Are animal models of diabetes relevant to the study of the genetics of non-insulin-dependent diabetes in humans? , 1997, Diabetes & metabolism.

[34]  E. Bonora,et al.  Relationships between insulin secretion, insulin metabolism and insulin resistance in mild glucose intolerance. , 1987, Diabete & metabolisme.

[35]  E. Rojas,et al.  A method for the simultaneous measurement of insulin release and B cell membrane potential in single mouse islets of langerhans , 1981, Diabetologia.

[36]  P. Trinder,et al.  Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen , 1969, Journal of clinical pathology.

[37]  F. Krempler,et al.  Restoration of sterol-regulatory-element-binding protein-1c gene expression in HepG2 cells by peroxisome-proliferator-activated receptor-gamma co-activator-1alpha. , 2004, The Biochemical journal.

[38]  Marc Montminy,et al.  PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. , 2004, Nature medicine.

[39]  P. Puigserver,et al.  Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. , 2003, Developmental cell.

[40]  P. Puigserver,et al.  Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis. , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[41]  Jerry Donovan,et al.  Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. , 2003, Nature.

[42]  B. Goldstein Insulin resistance: from benign to type 2 diabetes mellitus. , 2003, Reviews in cardiovascular medicine.

[43]  D. Kass,et al.  Ventricular resynchronization: pathophysiology and identification of responders. , 2003, Reviews in cardiovascular medicine.