Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.

Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex. The affected cells are precisely those that interconnect the hippocampal formation with the association cortices, basal forebrain, thalamus, and hypothalamus, structures crucial to memory. This focal pattern of pathology isolates the hippocampal formation from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.

[1]  A. Hirano,et al.  Alzheimer's neurofibrillary changes. A topographic study. , 1962, Archives of neurology.

[2]  N. Geschwind.  Disconnexion syndromes in animals and man. I. , 1965, Brain : a journal of neurology.

[3]  N. Geschwind.  Disconnexion syndromes in animals and man. II. , 1965, Brain : a journal of neurology.

[4]  M. Roth,et al.  The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects , 1968, British Journal of Psychiatry.

[5]  N Butters,et al.  Cortical Afferents to the Entorhinal Cortex of the Rhesus Monkey , 1972, Science.

[6]  M. Ball,et al.  NEUROFIBRILLARY TANGLES AND THE PATHOGENESIS OF DEMENTIA: A QUANTITATIVE STUDY , 1976 .

[7]  P. Davies,et al.  SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASE , 1976, The Lancet.

[8]  O. Steward,et al.  Topographic organization of the projections from the entorhinal area to the hippocampal formation of the rat , 1976, The Journal of comparative neurology.

[9]  G. V. Van Hoesen,et al.  Hippocampal efferents reach widespread areas of cerebral cortex and amygdala in the rhesus monkey. , 1977, Science.

[10]  W. Cowan,et al.  An autoradiographic study of the organization of intrahippocampal association pathways in the rat , 1978, The Journal of comparative neurology.

[11]  E K Perry,et al.  Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. , 1978, British medical journal.

[12]  D L Rosene,et al.  Subicular input from temporal cortex in the rhesus monkey. , 1979, Science.

[13]  M. Mesulam,et al.  Tracing neural connections of human brain with selective silver impregnation. Observations on geniculocalcarine, spinothalamic, and entorhinal pathways. , 1979, Archives of neurology.

[14]  T. Kemper,et al.  Amygdaloid changes in aging and dementia. , 1980, Archives of neurology.

[15]  A. Brun,et al.  Regional pattern of degeneration in Alzheimer's disease: neuronal loss and histopathological grading , 1981, Histopathology.

[16]  J. Coyle,et al.  Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. , 1982, Science.

[17]  M. Mishkin.  A memory system in the monkey. , 1982, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[18]  G. K. Wilcock,et al.  Plaques, tangles and dementia A quantitative study , 1982, Journal of the Neurological Sciences.

[19]  G. V. Van Hoesen,et al.  Prosopagnosia , 1982, Neurology.

[20]  R. Bartus,et al.  The cholinergic hypothesis of geriatric memory dysfunction. , 1982, Science.

[21]  G. V. Hoesen,et al.  Non-hippocampal cortical projections from the entorhinal cortex in the rat and rhesus monkey , 1982, Brain Research.

[22]  R. Marchbanks.  Biochemistry of Alzheimer's Dementia , 1982, Journal of neurochemistry.

[23]  G. V. Hoesen,et al.  The parahippocampal gyrus: New observations regarding its cortical connections in the monkey , 1982, Trends in Neurosciences.

[24]  F. E. Bloom,et al.  Loss of pigmented dopamine-β-hydroxylase positive cells from locus coeruleus in senile dementia of alzheimer's type , 1983, Neuroscience Letters.

[25]  M. Witter,et al.  Entorhinal efferents reach the caudato-putamen , 1983, Neuroscience Letters.

[26]  R. Terry,et al.  Senile dementia of the Alzheimer type , 1983, Annals of neurology.