Infection of swine ex vivo tissues with avian viruses including H7N9 and correlation with glycomic analysis

Swine have been regarded as intermediate hosts in the spread of influenza from birds to humans but studies of the sialylated glycans that comprise their respiratory tract have not been extensively studied in the past. This study analyzed the sialylated N‐glycan and O‐glycan profile of swine trachea and lung and correlated this with ex‐vivo infection of swine explants with avian influenza viruses.

[1]  Y. Guan,et al.  Infectivity, Transmission, and Pathology of Human-Isolated H7N9 Influenza Virus in Ferrets and Pigs , 2013, Science.

[2]  J. Nicholls,et al.  Effect of receptor specificity of A/Hong Kong/1/68 (H3N2) influenza virus variants on replication and transmission in pigs , 2012, Influenza and other respiratory viruses.

[3]  David L Smith,et al.  The Potential for Respiratory Droplet–Transmissible A/H5N1 Influenza Virus to Evolve in a Mammalian Host , 2012, Science.

[4]  Theo M Bestebroer,et al.  Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets , 2012, Science.

[5]  Ryan McBride,et al.  Recognition of sialylated poly-N-acetyllactosamine chains on N- and O-linked glycans by human and avian influenza A virus hemagglutinins. , 2012, Angewandte Chemie.

[6]  C. Davis,et al.  In vitro evolution of H5N1 avian influenza virus toward human-type receptor specificity. , 2012, Virology.

[7]  L. Larsen,et al.  Distribution of sialic acid receptors and influenza A virus of avian and swine origin in experimentally infected pigs , 2011, Virology Journal.

[8]  D. Jarvis,et al.  Letter to the Glyco-Forum: Effective glycoanalysis with Maackia amurensis lectins requires a clear understanding of their binding specificities , 2011 .

[9]  Gavin J. D. Smith,et al.  Long-term evolution and transmission dynamics of swine influenza A virus , 2011, Nature.

[10]  C. Davis,et al.  Receptor specificity of subtype H1 influenza A viruses isolated from swine and humans in the United States. , 2011, Virology.

[11]  N. Cox,et al.  Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza H5N1 viruses. , 2011, Virology.

[12]  Ryo Takano,et al.  Influenza A (H5N1) Viruses from Pigs, Indonesia , 2010, Emerging infectious diseases.

[13]  A. Dell,et al.  Glycan Analysis and Influenza A Virus Infection of Primary Swine Respiratory Epithelial Cells , 2010, The Journal of Biological Chemistry.

[14]  Y. Guan,et al.  Immunopathology and Infectious Diseases Tropism and Innate Host Responses of the 2009 Pandemic H 1 N 1 Influenza Virus in ex Vivo and in Vitro Cultures of Human Conjunctiva and Respiratory Tract , 2010 .

[15]  S. Dunham,et al.  Comparative distribution of human and avian type sialic acid influenza receptors in the pig , 2010, BMC veterinary research.

[16]  H. Nauwynck,et al.  Replication of avian, human and swine influenza viruses in porcine respiratory explants and association with sialic acid distribution , 2010, Virology Journal.

[17]  Kuk Jin Park,et al.  Evaluation of the Efficacy and Cross-Protectivity of Recent Human and Swine Vaccines against the Pandemic (H1N1) 2009 Virus Infection , 2009, PloS one.

[18]  H. Shiota,et al.  Influenza vaccine with Surfacten, a modified pulmonary surfactant, induces systemic and mucosal immune responses without side effects in minipigs. , 2009, Vaccine.

[19]  Hideo Goto,et al.  In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses , 2009, Nature.

[20]  Fang Fang,et al.  DAS181 Inhibits H5N1 Influenza Virus Infection of Human Lung Tissues , 2009, Antimicrobial Agents and Chemotherapy.

[21]  Yin Wu,et al.  MR study of the effect of infarct size and location on left ventricular functional and microstructural alterations in porcine models , 2009, Journal of magnetic resonance imaging : JMRI.

[22]  D. Suarez,et al.  Domestic Pigs Have Low Susceptibility to H5N1 Highly Pathogenic Avian Influenza Viruses , 2008, PLoS pathogens.

[23]  J. Gern,et al.  Identification of amino acids in the HA of H3 influenza viruses that determine infectivity levels in primary swine respiratory epithelial cells. , 2008, Virus research.

[24]  M. Kinoshita,et al.  Rapid and sensitive analysis of mucin-type glycans using an in-line flow glycan-releasing apparatus. , 2007, Analytical biochemistry.

[25]  A. J. Bourne,et al.  Sialic acid receptor detection in the human respiratory tract: evidence for widespread distribution of potential binding sites for human and avian influenza viruses , 2007, Respiratory research.

[26]  Ron A M Fouchier,et al.  Immunopathology and Infectious Disease Human and Avian Influenza Viruses Target Different Cells in the Lower Respiratory Tract of Humans and Other Mammals , 2010 .

[27]  David F. Smith,et al.  Receptor binding specificity of recent human H3N2 influenza viruses , 2007, Virology Journal.

[28]  Naoyuki Taniguchi,et al.  Comparison of the methods for profiling glycoprotein glycans--HUPO Human Disease Glycomics/Proteome Initiative multi-institutional study. , 2007, Glycobiology.

[29]  Y. Guan,et al.  Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract , 2007, Nature Medicine.

[30]  K. Van Reeth.  Avian and swine influenza viruses: our current understanding of the zoonotic risk. , 2007, Veterinary research.

[31]  Yoshihiro Kawaoka,et al.  Avian flu: Influenza virus receptors in the human airway , 2006, Nature.

[32]  Mark Sutton-Smith,et al.  Glycomic profiling of cells and tissues by mass spectrometry: fingerprinting and sequencing methodologies. , 2006, Methods in enzymology.

[33]  Takashi Yamada,et al.  Evaluation of the ESPLINE® INFLUENZA A&B‐N Kit for the Diagnosis of Avian and Swine Influenza , 2005, Microbiology and immunology.

[34]  K. Hartshorn,et al.  Interactions of influenza A virus with sialic acids present on porcine surfactant protein D. , 2004, American journal of respiratory cell and molecular biology.

[35]  Yoshihiro Kawaoka,et al.  Molecular Basis for the Generation in Pigs of Influenza A Viruses with Pandemic Potential , 1998, Journal of Virology.

[36]  R. Webster,et al.  Potential for transmission of avian influenza viruses to pigs. , 1994, The Journal of general virology.

[37]  R. Cummings,et al.  Frameshift and nonsense mutations in a human genomic sequence homologous to a murine UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase cDNA. , 1990, The Journal of biological chemistry.

[38]  J. Paulson,et al.  Sialyloligosaccharides of the respiratory epithelium in the selection of human influenza virus receptor specificity. , 1990, Acta histochemica. Supplementband.

[39]  C. Scholtissek,et al.  The nucleoprotein as a possible major factor in determining host specificity of influenza H3N2 viruses. , 1985, Virology.

[40]  I. Wilson,et al.  Single amino acid substitutions in influenza haemagglutinin change receptor binding specificity , 1983, Nature.

[41]  J. Paulson,et al.  Receptor determinants of human and animal influenza virus isolates: differences in receptor specificity of the H3 hemagglutinin based on species of origin. , 1983, Virology.