Mitochondrial aconitase suppresses immunity by modulating oxaloacetate and the mitochondrial unfolded protein response

[1]  A. Zahler,et al.  A forward genetic screen in C. elegans identifies conserved residues of spliceosomal proteins PRP8 and SNRNP200/BRR2 with a role in maintaining 5′ splice site identity , 2022, Nucleic acids research.

[2]  Jianlin Tan,et al.  NHR-80 senses the mitochondrial UPR to rewire citrate metabolism for lipid accumulation in Caenorhabditis elegans. , 2022, Cell reports.

[3]  M. Mistry,et al.  Mild mitochondrial impairment enhances innate immunity and longevity through ATFS‐1 and p38 signaling , 2021, EMBO reports.

[4]  M. Mistry,et al.  Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors , 2021, Life Science Alliance.

[5]  M. Francesconi,et al.  Real age prediction from the transcriptome with RAPToR , 2021, Nature Methods.

[6]  M. Mistry,et al.  Genetic basis of enhanced stress resistance in long‐lived mutants highlights key role of innate immunity in determining longevity , 2021, bioRxiv.

[7]  C. Murphy,et al.  Reduced insulin/IGF1 signaling prevents immune aging via ZIP-10/bZIP–mediated feedforward loop , 2021, The Journal of cell biology.

[8]  Benson Otarigho,et al.  Immunity-longevity tradeoff neurally controlled by GABAergic transcription factor PITX1/UNC-30 , 2021, bioRxiv.

[9]  A. Antebi,et al.  Regulation of the one carbon folate cycle as a shared metabolic signature of longevity , 2020, Nature Communications.

[10]  Kyong-Tai Kim,et al.  VRK-1 extends life span by activation of AMPK via phosphorylation , 2020, Science Advances.

[11]  A. Antebi,et al.  NFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin , 2020, Nature metabolism.

[12]  L. O’Neill,et al.  Cytokine-like Roles for Metabolites in Immunity. , 2020, Molecular cell.

[13]  Tae-Young Roh,et al.  Inhibition of the oligosaccharyl transferase in Caenorhabditis elegans that compromises ER proteostasis suppresses p38-dependent protection against pathogenic bacteria , 2020, PLoS genetics.

[14]  N. Chandel,et al.  Mitochondrial TCA cycle metabolites control physiology and disease , 2020, Nature Communications.

[15]  A. Mehta,et al.  The SDHB Arg230His mutation causing familial paraganglioma alters glycolysis in a new Caenorhabditis elegans model , 2020, Disease Models & Mechanisms.

[16]  G. Maulucci,et al.  Aconitase 2 inhibits the proliferation of MCF-7 cells promoting mitochondrial oxidative metabolism and ROS/FoxO1-mediated autophagic response , 2019, British Journal of Cancer.

[17]  G. Pazour,et al.  WormCat: An Online Tool for Annotation and Visualization of Caenorhabditis elegans Genome-Scale Data , 2019, Genetics.

[18]  Chen-Yu Liao,et al.  Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice , 2019, bioRxiv.

[19]  M. Driscoll,et al.  The longevity-promoting factor, TCER-1, widely represses stress resistance and innate immunity , 2019, Nature Communications.

[20]  Michael J. Steinbaugh,et al.  Dietary Restriction Extends Lifespan through Metabolic Regulation of Innate Immunity. , 2019, Cell metabolism.

[21]  L. Zhu,et al.  Mitochondrial UPR repression during Pseudomonas aeruginosa infection requires the bZIP protein ZIP-3 , 2019, Proceedings of the National Academy of Sciences.

[22]  P. Nicotera,et al.  Multi‐omics identify xanthine as a pro‐survival metabolite for nematodes with mitochondrial dysfunction , 2019, The EMBO journal.

[23]  Vincent L. Butty,et al.  Global transcriptional regulation of innate immunity by ATF-7 in C. elegans , 2019, PLoS genetics.

[24]  Edward T Chouchani,et al.  Coupling Krebs cycle metabolites to signalling in immunity and cancer , 2018, Nature Metabolism.

[25]  A. Antebi,et al.  Nucleolar fibrillarin is an evolutionarily conserved regulator of bacterial pathogen resistance , 2018, Nature Communications.

[26]  Mu Xu,et al.  Oxaloacetate induces apoptosis in HepG2 cells via inhibition of glycolysis , 2018, Cancer medicine.

[27]  J. V. Van Raamsdonk,et al.  Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans , 2018, PLoS genetics.

[28]  J. Auwerx,et al.  The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress , 2017, Nature Communications.

[29]  Cole M. Haynes,et al.  The mitochondrial UPR: mechanisms, physiological functions and implications in ageing , 2017, Nature Reviews Molecular Cell Biology.

[30]  L. Partridge,et al.  Small nucleoli are a cellular hallmark of longevity , 2017, Nature Communications.

[31]  Liuqin He,et al.  Administration of alpha-ketoglutarate improves epithelial restitution under stress injury in early-weaning piglets , 2017, Oncotarget.

[32]  L. O’Neill,et al.  Mitochondria are the powerhouses of immunity , 2017, Nature Immunology.

[33]  C. Ha,et al.  Mitochondrial chaperone HSP‐60 regulates anti‐bacterial immunity via p38 MAP kinase signaling , 2017, The EMBO journal.

[34]  Modi Safra,et al.  Innate immunity mediated longevity and longevity induced by germ cell removal converge on the C-type lectin domain protein IRG-7 , 2017, PLoS genetics.

[35]  Annie L. Conery,et al.  Tribbles ortholog NIPI-3 and bZIP transcription factor CEBP-1 regulate a Caenorhabditis elegans intestinal immune surveillance pathway , 2016, BMC Biology.

[36]  Jae-Seong Yang,et al.  OASIS 2: online application for survival analysis 2 with features for the analysis of maximal lifespan and healthspan in aging research , 2016, Oncotarget.

[37]  Cole M. Haynes,et al.  The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR , 2016, Current Biology.

[38]  Evan G. Williams,et al.  Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity , 2016, Cell.

[39]  Stuart K. Kim,et al.  Deactivation of the GATA Transcription Factor ELT-2 Is a Major Driver of Normal Aging in C. elegans , 2016, PLoS genetics.

[40]  Y. Pinto,et al.  A targeted metabolomics assay for cardiac metabolism and demonstration using a mouse model of dilated cardiomyopathy , 2016, Metabolomics.

[41]  S. Weinberg,et al.  Mitochondria in the regulation of innate and adaptive immunity. , 2015, Immunity.

[42]  G. Ruvkun,et al.  Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa , 2015, Proceedings of the National Academy of Sciences.

[43]  W. Brooks,et al.  Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis. , 2014, Human molecular genetics.

[44]  W. Huber,et al.  Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.

[45]  A. Munnich,et al.  Mutations in the tricarboxylic acid cycle enzyme, aconitase 2, cause either isolated or syndromic optic neuropathy with encephalopathy and cerebellar atrophy , 2014, Journal of Medical Genetics.

[46]  Cole M. Haynes,et al.  Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection , 2014, Nature.

[47]  Nnamdi E. Ihuegbu,et al.  Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes. , 2014, Immunity.

[48]  Hilary A. Godwin,et al.  The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR , 2014, Nature.

[49]  G. Ruvkun,et al.  Caenorhabditis elegans pathways that surveil and defend mitochondria , 2014, Nature.

[50]  J. Nunnari,et al.  Mitochondrial form and function , 2014, Nature.

[51]  H. Hutter,et al.  The NHR-8 nuclear receptor regulates cholesterol and bile acid homeostasis in C. elegans. , 2013, Cell metabolism.

[52]  John Canfield,et al.  Malate and Fumarate Extend Lifespan in Caenorhabditis elegans , 2013, PloS one.

[53]  Cole M. Haynes,et al.  Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation , 2012, Science.

[54]  G. Ruvkun,et al.  Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses , 2012, Cell.

[55]  P. Csermely,et al.  A Role for SKN-1/Nrf in Pathogen Resistance and Immunosenescence in Caenorhabditis elegans , 2012, PLoS pathogens.

[56]  L. Feuk,et al.  Infantile cerebellar-retinal degeneration associated with a mutation in mitochondrial aconitase, ACO2. , 2012, American journal of human genetics.

[57]  Jae-Seong Yang,et al.  OASIS: Online Application for the Survival Analysis of Lifespan Assays Performed in Aging Research , 2011, PloS one.

[58]  Colin N. Dewey,et al.  RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome , 2011, BMC Bioinformatics.

[59]  R. Medzhitov Inflammation 2010: New Adventures of an Old Flame , 2010, Cell.

[60]  Frederick M. Ausubel,et al.  bZIP transcription factor zip-2 mediates an early response to Pseudomonas aeruginosa infection in Caenorhabditis elegans , 2010, Proceedings of the National Academy of Sciences.

[61]  Tanja Diemer,et al.  Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO‐dependent pathway , 2009, Aging cell.

[62]  C. Murphy,et al.  Condition‐adapted stress and longevity gene regulation by Caenorhabditis elegans SKN‐1/Nrf , 2009, Aging cell.

[63]  Leonid Kruglyak,et al.  A Polymorphism in npr-1 Is a Behavioral Determinant of Pathogen Susceptibility in C. elegans , 2009, Science.

[64]  Trupti Kawli,et al.  Pseudomonas aeruginosa Suppresses Host Immunity by Activating the DAF-2 Insulin-Like Signaling Pathway in Caenorhabditis elegans , 2008, PLoS pathogens.

[65]  T. Johnson,et al.  Relationship Between Mitochondrial Electron Transport Chain Dysfunction, Development, and Life Extension in Caenorhabditis elegans , 2007, PLoS biology.

[66]  Hedi Peterson,et al.  g:Profiler—a web-based toolset for functional profiling of gene lists from large-scale experiments , 2007, Nucleic Acids Res..

[67]  Varsha Singh,et al.  Heat-shock transcription factor (HSF)-1 pathway required for Caenorhabditis elegans immunity , 2006, Proceedings of the National Academy of Sciences.

[68]  Richard O Jenkins,et al.  Toxicology of fluoroacetate: a review, with possible directions for therapy research , 2006, Journal of applied toxicology : JAT.

[69]  D. Toroser,et al.  Aconitase is the main functional target of aging in the citric acid cycle of kidney mitochondria from mice , 2006, Mechanisms of Ageing and Development.

[70]  Pablo Tamayo,et al.  Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[71]  David E Hill,et al.  Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. , 2004, Genome research.

[72]  F. Ausubel,et al.  Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[73]  Gary Ruvkun,et al.  Long-Lived C. elegans daf-2 Mutants Are Resistant to Bacterial Pathogens , 2003, Science.

[74]  Andrew G Fraser,et al.  Rates of Behavior and Aging Specified by Mitochondrial Function During Development , 2002, Science.

[75]  R. S. Sohal,et al.  Selectivity of protein oxidative damage during aging in Drosophila melanogaster. , 2001, The Biochemical journal.

[76]  F. Ausubel,et al.  Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[77]  R. S. Sohal,et al.  Oxidative damage during aging targets mitochondrial aconitase. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[78]  K. Yoshikawa Studies on Anti-diabetic Effect of Sodium Oxalcacetate , 1968 .

[79]  Thomas R. Gingeras,et al.  STAR: ultrafast universal RNA-seq aligner , 2013, Bioinform..

[80]  Eyal Gottlieb,et al.  Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. , 2005, Cancer cell.

[81]  Gary Ruvkun,et al.  A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity , 2003, Nature Genetics.