A2A antagonist prevents dopamine agonist-induced motor complications in animal models of Parkinson’s disease

[1]  Alfred I Geller,et al.  Gene transfer of constitutively active protein kinase C into striatal neurons accelerates onset of levodopa-induced motor response alterations in parkinsonian rats , 2003, Brain Research.

[2]  P. Greengard,et al.  Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[3]  Michele Zoli,et al.  Coaggregation, Cointernalization, and Codesensitization of Adenosine A2A Receptors and Dopamine D2Receptors* , 2002, The Journal of Biological Chemistry.

[4]  E. Bézard,et al.  From single extracellular unit recording in experimental and human Parkinsonism to the development of a functional concept of the role played by the basal ganglia in motor control , 2002, Progress in Neurobiology.

[5]  E. Ongini,et al.  Persistent Behavioral Sensitization to Chronic l-DOPA Requires A2A Adenosine Receptors , 2002, The Journal of Neuroscience.

[6]  P. D. Hughes,et al.  Antagonistic effects of dopaminergic signaling and ethanol on protein kinase A-mediated phosphorylation of DARPP-32 and the NR1 subunit of the NMDA receptor. , 2002, Alcoholism, clinical and experimental research.

[7]  C. Duarte,et al.  Phosphorylation of GluR4 AMPA‐type glutamate receptor subunit by protein kinase C in cultured retina amacrine neurons , 2002, The European journal of neuroscience.

[8]  B. Fredholm,et al.  Diverse inhibitors of intracellular signalling act as adenosine receptor antagonists. , 2002, Cellular signalling.

[9]  K. Ikeda,et al.  Neuroprotection by adenosine A2A receptor blockade in experimental models of Parkinson's disease , 2002, Journal of neurochemistry.

[10]  N. Wierup,et al.  Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson's disease , 2002, The European journal of neuroscience.

[11]  D. Brooks,et al.  Evaluation of [4‐O‐methyl‐11C]KW‐6002 as a potential PET ligand for mapping central adenosine A2A receptors in rats , 2001, Synapse.

[12]  T. Chase,et al.  Serotonin 5-HT1A agonist improves motor complications in rodent and primate parkinsonian models , 2001, Neurology.

[13]  Y. Agid,et al.  LY293558, an AMPA glutamate receptor antagonist, prevents and reverses levodopa‐induced motor alterations in Parkinsonian rats , 2001, Synapse.

[14]  M. Andersson,et al.  Persistent changes in striatal gene expression induced by long‐term l‐DOPA treatment in a rat model of Parkinson's disease , 2001, The European journal of neuroscience.

[15]  P. Janak,et al.  In Vivo Extracellular Recording of Striatal Neurons in the Awake Rat Following Unilateral 6-Hydroxydopamine Lesions , 2001, Experimental Neurology.

[16]  M. Schwarzschild,et al.  Neuroprotection by Caffeine and A2A Adenosine Receptor Inactivation in a Model of Parkinson's Disease , 2001, The Journal of Neuroscience.

[17]  K. Keefe,et al.  Examination of the involvement of protein kinase A in D2 dopamine receptor antagonist‐induced immediate early gene expression , 2001, Journal of neurochemistry.

[18]  J. Linden,et al.  Ultrastructural localization of adenosine A2A receptors suggests multiple cellular sites for modulation of GABAergic neurons in rat striatum , 2001, The Journal of comparative neurology.

[19]  M. Morelli,et al.  Interaction between dopamine and adenosine A2A receptors as a basis for the treatment of Parkinson's disease , 2001, Neurological Sciences.

[20]  R. Cunha,et al.  Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: different roles, different sources and different receptors , 2001, Neurochemistry International.

[21]  H. Kase.  New Aspects of Physiological and Pathophysiological Functions of Adenosine A2A Receptor in Basal Ganglia , 2001, Bioscience, biotechnology, and biochemistry.

[22]  M. Ochi,et al.  Adenosine A(2A) receptor antagonists KF17837 and KW-6002 potentiate rotation induced by dopaminergic drugs in hemi-Parkinsonian rats. , 2000, European journal of pharmacology.

[23]  C. Duarte,et al.  Regulation of AMPA Receptors by Phosphorylation , 2000, Neurochemical Research.

[24]  T. Chase,et al.  Striatal dopamine- and glutamate-mediated dysregulation in experimental parkinsonism , 2000, Trends in Neurosciences.

[25]  R. Cunha,et al.  Adenosine A2A receptor facilitation of synaptic transmission in the CA1 area of the rat hippocampus requires protein kinase C but not protein kinase A activation , 2000, Neuroscience Letters.

[26]  Hiroshi Kase,et al.  Rescue of Locomotor Impairment in Dopamine D2 Receptor-Deficient Mice by an Adenosine A2A Receptor Antagonist , 2000, The Journal of Neuroscience.

[27]  M. Bear,et al.  Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity , 2000, Nature.

[28]  D. Rosenbaum,et al.  Signal transduction mechanisms involved in ischemic preconditioning in the rat retina in vivo. , 2000, Experimental eye research.

[29]  S. Konitsiotis,et al.  AMPA receptor blockade improves levodopa-induced dyskinesia in MPTP monkeys , 2000, Neurology.

[30]  A. Benabid,et al.  Dyskinesias and the subthalamic nucleus. , 2000, Annals of neurology.

[31]  R. Malinow,et al.  Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction. , 2000, Science.

[32]  P. Jenner,et al.  Alterations in preproenkephalin and adenosine‐2a receptor mRNA, but not preprotachykinin mRNA correlate with occurrence of dyskinesia in normal monkeys chronically treated with l‐DOPA , 2000, The European journal of neuroscience.

[33]  L. Butcher,et al.  Overexpression of neurotrophin receptor p75 contributes to the excitotoxin-induced cholinergic neuronal death in rat basal forebrain , 2000, Brain Research.

[34]  P. Svenningsson,et al.  Distribution, biochemistry and function of striatal adenosine A2A receptors , 1999, Progress in Neurobiology.

[35]  L. Grégoire,et al.  Antiparkinsonian effect of a new selective adenosine A2A receptor antagonist in MPTP-treated monkeys , 1999, Neurology.

[36]  T. Chase,et al.  Effect of dopamine denervation and dopamine agonist administration on serine phosphorylation of striatal nmda receptor subunits , 1999, Brain Research.

[37]  J. Linden,et al.  Immunohistochemical localization of adenosine A2A receptors in the rat central nervous system , 1998, The Journal of comparative neurology.

[38]  P. Jenner,et al.  Adenosine A2A Antagonist: A novel antiparkinsonian agent that does not provoke dyskinesia in Parkinsonian monkeys , 1998, Annals of neurology.

[39]  N. Choksi,et al.  2-Phenylaminoadenosine stimulates dopamine synthesis in rat forebrain in vitro and in vivo via adenosine A2 receptors , 1997, Brain Research.

[40]  T. Chase,et al.  Protein kinase A inhibitor attenuates levodopa-induced motor response alterations in the hemi-parkinsonian rat , 1997, Neuroscience Letters.

[41]  Kyong-Tai Kim,et al.  A2A Adenosine Receptors Inhibit ATP‐Induced Ca2+ Influx in PC12 Cells by Involving Protein Kinase A , 1997, Journal of neurochemistry.

[42]  B. Fredholm,et al.  Pharmacology of adenosine A2A receptors. , 1996, Trends in pharmacological sciences.

[43]  S. Latini,et al.  A2 adenosine receptors: their presence and neuromodulatory role in the central nervous system. , 1996, General pharmacology.

[44]  A. Gubitz,et al.  Dual Signalling by the Adenosine A2a Receptor Involves Activation of Both N‐ and P‐Type Calcium Channels by Different G Proteins and Protein Kinases in the Same Striatal Nerve Terminals , 1996, Journal of neurochemistry.

[45]  R. Huganir,et al.  Characterization of Multiple Phosphorylation Sites on the AMPA Receptor GluR1 Subunit , 1996, Neuron.

[46]  R. Ebstein,et al.  Release of norepinephrine and dopamine from brain vesicular preparations: Effects of adenosine analogues , 1982, Cellular and Molecular Neurobiology.

[47]  T. Szabo,et al.  Synaptic structure of the lateral line lobe nucleus in mormyrid fish , 1976, Neuroscience Letters.

[48]  N. J. Giarman,et al.  5‐HYDROXYTRYPTAMINE (SEROTONIN, ENTERAMINE) CONTENT OF STRUCTURES OF THE LIMBIC SYSTEM * , 1957, Journal of neurochemistry.

[49]  J. Bennett,et al.  Effects of single and multiple treatments with L‐dihydroxyphenylalanine (L‐DOPA) on dopamine receptor–G protein interactions and supersensitive immediate early gene responses in striata of rats after reserpine treatment or with unilateral nigrostriatal lesions , 1999, Journal of neuroscience research.

[50]  G. Paxinos,et al.  The Rat Brain in Stereotaxic Coordinates , 1983 .