Polymorphisms in the Aromatase Gene Predict Areal BMD as a Result of Affected Cortical Bone Size: The GOOD Study

The association between aromatase gene polymorphisms, bone parameters, and sex steroid levels was studied in 1068 men (18.9 ± 0.6 years of age). Several aromatase gene polymorphisms were found to be associated with serum testosterone levels and cortical bone size but not with trabecular volumetric BMD.

[1]  J. Pasco,et al.  Femoral neck geometry and hip fracture risk: the Geelong osteoporosis study , 2005, Osteoporosis International.

[2]  D. Mellström,et al.  Free Testosterone Is a Positive, Whereas Free Estradiol Is a Negative, Predictor of Cortical Bone Size in Young Swedish Men: The GOOD Study , 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[3]  D. Mellström,et al.  Age of Attainment of Peak Bone Mass Is Site Specific in Swedish Men—The GOOD Study , 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[4]  J. Riancho,et al.  Aromatase gene and osteoporosis: relationship of ten polymorphic loci with bone mineral density. , 2005, Bone.

[5]  C. Slemenda,et al.  The contribution of bone loss to postmenopausal osteoporosis , 1990, Osteoporosis International.

[6]  R. Rizzoli,et al.  Peak bone mass , 2005, Osteoporosis International.

[7]  J. Bilezikian,et al.  Aromatase activity and bone homeostasis in men. , 2004, The Journal of clinical endocrinology and metabolism.

[8]  U. Stenman,et al.  Serum estradiol, testosterone, and sex hormone-binding globulin as regulators of peak bone mass and bone turnover rate in young Finnish men. , 2004, The Journal of clinical endocrinology and metabolism.

[9]  J. Riancho,et al.  Age-related influence of common aromatase gene polymorphisms on bone mass of healthy men. , 2004, Bone.

[10]  M. Brandi,et al.  A polymorphic CYP19 TTTA repeat influences aromatase activity and estrogen levels in elderly men: effects on bone metabolism. , 2004, The Journal of clinical endocrinology and metabolism.

[11]  J. Riancho,et al.  A common polymorphism in the 5'-untranslated region of the aromatase gene influences bone mass and fracture risk. , 2004, European journal of endocrinology.

[12]  S. Ralston,et al.  Polymorphisms in the P450 c17 (17-hydroxylase/17,20-Lyase) and P450 c19 (aromatase) genes: association with serum sex steroid concentrations and bone mineral density in postmenopausal women. , 2004, The Journal of clinical endocrinology and metabolism.

[13]  J. Kaufman,et al.  Bioavailable estradiol and an aromatase gene polymorphism are determinants of bone mineral density changes in men over 70 years of age. , 2003, The Journal of clinical endocrinology and metabolism.

[14]  M. Bouxsein,et al.  Predicting the failure load of the distal radius , 2003, Osteoporosis International.

[15]  R. Rauramaa,et al.  Aerobic exercise and bone mineral density in middle-aged finnish men: a controlled randomized trial with reference to androgen receptor, aromatase, and estrogen receptor α gene polymorphisms , 2003 .

[16]  E. Orwoll.  Men, bone and estrogen: unresolved issues , 2003, Osteoporosis International.

[17]  R. Honkanen,et al.  Relation of aromatase gene polymorphism and hormone replacement therapy to serum estradiol levels, bone mineral density, and fracture risk in early postmenopausal women* , 2003, Annals of medicine.

[18]  R. Rauramaa,et al.  Aerobic exercise and bone mineral density in middle-aged finnish men: a controlled randomized trial with reference to androgen receptor, aromatase, and estrogen receptor alpha gene polymorphisms. , 2003, Bone.

[19]  P. Delmas,et al.  Independent predictors of all osteoporosis-related fractures in healthy postmenopausal women: the OFELY study. , 2003, Bone.

[20]  O. Cussenot,et al.  Impact of constitutional genetic variation in androgen/oestrogen-regulating genes on age-related changes in human prostate. , 2002, European journal of endocrinology.

[21]  Sundeep Khosla,et al.  Sex steroids and the construction and conservation of the adult skeleton. , 2002, Endocrine reviews.

[22]  L. Melton,et al.  Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men. , 2001, The Journal of clinical endocrinology and metabolism.

[23]  M. Brandi,et al.  Polymorphism of the aromatase gene in postmenopausal Italian women: distribution and correlation with bone mass and fracture risk. , 2001, The Journal of clinical endocrinology and metabolism.

[24]  E. Simpson,et al.  Role of aromatase in sex steroid action. , 2000, Journal of molecular endocrinology.

[25]  D. Grobbee,et al.  Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men. , 2000, The Journal of clinical endocrinology and metabolism.

[26]  J. Gustafsson,et al.  Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[27]  P. Lønning,et al.  Genetic variants of CYP19 (aromatase) and breast cancer risk , 2000, Breast Cancer Research.

[28]  O. Johnell,et al.  Long-Term Risk of Osteoporotic Fracture in Malmö , 2000, Osteoporosis International.

[29]  R. Lorentzon,et al.  The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 1999 by The Endocrine Society Estrogen Receptor Gene Polymorphism, But Not Estradiol Levels, Is Related to Bone Density in Healthy Adolescent Boys: A Cross-Sectional and , 2022 .

[30]  A. Vermeulen,et al.  A critical evaluation of simple methods for the estimation of free testosterone in serum. , 1999, The Journal of clinical endocrinology and metabolism.

[31]  Magnus Jobs,et al.  Dynamic allele-specific hybridization , 1999, Nature Biotechnology.

[32]  A. Brookes,et al.  Dynamic allele-specific hybridization. A new method for scoring single nucleotide polymorphisms. , 1999, Nature biotechnology.

[33]  R. Rizzoli,et al.  Determinants of Peak Bone Mass and Mechanisms of Bone Loss , 1999, Osteoporosis International.

[34]  E. Seeman,et al.  Osteoporosis in Men , 1999, Osteoporosis International.

[35]  A. Hofman,et al.  Hip Fracture Prediction in Elderly Men and Women: Validation in the Rotterdam Study , 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[36]  G G Klee,et al.  Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1998 by The Endocrine Society Relationship of Serum Sex Steroid Levels and Bone Turnover Markers with Bone Mineral Density in Men and Women: A Key Role for Bioavailable Estroge , 2022 .

[37]  B. L. Riggs,et al.  A Unitary Model for Involutional Osteoporosis: Estrogen Deficiency Causes Both Type I and Type II Osteoporosis in Postmenopausal Women and Contributes to Bone Loss in Aging Men , 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[38]  E. Barrett-Connor,et al.  Endogenous Sex Steroids and Bone Mineral Density in Older Women and Men: The Rancho Bernardo Study , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[39]  C. Slemenda,et al.  Sex steroids and bone mass in older men. Positive associations with serum estrogens and negative associations with androgens. , 1997, The Journal of clinical investigation.

[40]  K. Korach,et al.  Effect of testosterone and estradiol in a man with aromatase deficiency. , 1997, The New England journal of medicine.

[41]  O. Johnell,et al.  World-wide Projections for Hip Fracture , 1997, Osteoporosis International.

[42]  J. Carpten,et al.  Modulation of non-templated nucleotide addition by Taq DNA polymerase: primer modifications that facilitate genotyping. , 1996, BioTechniques.

[43]  S. Boonen,et al.  Androgens and bone. , 2004, Calcified tissue international.

[44]  E. Simpson,et al.  Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. , 1995, The Journal of clinical endocrinology and metabolism.

[45]  J. Eisman,et al.  Genetic influences on bone turnover, bone density and fracture. , 1995, European journal of endocrinology.

[46]  C C Glüer,et al.  Simple measurement of femoral geometry predicts hip fracture: The study of osteoporotic fractures , 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.