Phenotypical and functional specialization of FOXP3+ regulatory T cells

[1]  A. Liston,et al.  Regulatory T Cells , 2011, Methods in Molecular Biology.

[2]  G. Trinchieri,et al.  Type I interferon: friend or foe? , 2010, The Journal of experimental medicine.

[3]  Christophe Benoist,et al.  Stability of the Regulatory T Cell Lineage in Vivo , 2010, Science.

[4]  David Baltimore,et al.  Function of miR-146a in Controlling Treg Cell-Mediated Regulation of Th1 Responses , 2010, Cell.

[5]  S. Zheng,et al.  Cutting Edge: All-Trans Retinoic Acid Sustains the Stability and Function of Natural Regulatory T Cells in an Inflammatory Milieu , 2010, The Journal of Immunology.

[6]  M. Petri,et al.  Interferon‐alpha regulates the dynamic balance between human activated regulatory and effector T cells: implications for antiviral and autoimmune responses , 2010, Immunology.

[7]  S. Sakaguchi,et al.  Regulatory T cells in tumor immunity , 2010, International journal of cancer.

[8]  T. Chatila,et al.  Skin Inflammation Arising from Cutaneous Regulatory T Cell Deficiency Leads to Impaired Viral Immune Responses , 2010, The Journal of Immunology.

[9]  D. Umetsu,et al.  The many paths to asthma: phenotype shaped by innate and adaptive immunity , 2010, Nature Immunology.

[10]  T. Kishimoto.  IL-6: from its discovery to clinical applications. , 2010, International immunology.

[11]  W. Paul,et al.  Differentiation of effector CD4 T cell populations (*). , 2010, Annual review of immunology.

[12]  C. Weston,et al.  Distinct Roles for CCR4 and CXCR3 in the Recruitment and Positioning of Regulatory T Cells in the Inflamed Human Liver , 2010, The Journal of Immunology.

[13]  L. Fetler,et al.  Foxp3+ T cells induce perforin-dependent dendritic cell death in tumor-draining lymph nodes. , 2010, Immunity.

[14]  S. Benoit,et al.  Tumor necrosis factor alpha blockade exacerbates murine psoriasis-like disease by enhancing Th17 function and decreasing expansion of Treg cells. , 2010, Arthritis and rheumatism.

[15]  M. Izad,et al.  Effect of IFN-ß therapy on the frequency and function of CD4+CD25+ regulatory T cells and Foxp3 gene expression in relapsing–remitting multiple sclerosis (RRMS): A preliminary study , 2010, Journal of Neuroimmunology.

[16]  Xin Chen,et al.  TNF-alpha: an activator of CD4+FoxP3+TNFR2+ regulatory T cells. , 2010, Current directions in autoimmunity.

[17]  J. Thierry-Mieg,et al.  Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors. , 2009, Immunity.

[18]  A. Abbas,et al.  Cutting Edge: The Th1 Response Inhibits the Generation of Peripheral Regulatory T Cells , 2009, The Journal of Immunology.

[19]  H. Hoffman.  Therapy of autoinflammatory syndromes. , 2009, The Journal of allergy and clinical immunology.

[20]  Y. Belkaid,et al.  Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection. , 2009, Immunity.

[21]  A. Rudensky,et al.  CD4+ Regulatory T Cells Control TH17 Responses in a Stat3-Dependent Manner , 2009, Science.

[22]  Toshiharu Onodera,et al.  Constitutive Expression of IDO by Dendritic Cells of Mesenteric Lymph Nodes: Functional Involvement of the CTLA-4/B7 and CCL22/CCR4 Interactions1 , 2009, The Journal of Immunology.

[23]  D. Bourdette,et al.  Interferon-beta-1a treatment increases CD56bright natural killer cells and CD4+CD25+ Foxp3 expression in subjects with multiple sclerosis , 2009, Journal of Neuroimmunology.

[24]  G. Nepom,et al.  Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells , 2009, Journal of leukocyte biology.

[25]  J. Bluestone,et al.  Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo , 2009, Nature Immunology.

[26]  Michael L. Dustin,et al.  Feedback control of regulatory T cell homeostasis by dendritic cells in vivo , 2009, The Journal of experimental medicine.

[27]  A. Ray,et al.  STAT6 Activation Confers upon T Helper Cells Resistance to Suppression by Regulatory T Cells1 , 2009, The Journal of Immunology.

[28]  C. Benoist,et al.  Foxp3+ regulatory T cells: differentiation, specification, subphenotypes , 2009, Nature Immunology.

[29]  L. Bradley.  Faculty Opinions recommendation of The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. , 2009 .

[30]  R. Proia,et al.  S1P1 receptor overrides regulatory T cell-mediated immune suppression through Akt-mTOR , 2009, Nature Immunology.

[31]  P. Bach,et al.  Expansion of Antigen-Specific Regulatory T Cells with the Topical Vitamin D Analog Calcipotriol1 , 2009, The Journal of Immunology.

[32]  N. Nishimoto,et al.  Clinical value of blocking IL-6 receptor , 2009, Current opinion in rheumatology.

[33]  M. Swain,et al.  Natural killer T cells regulate the homing of chemokine CXC receptor 3‐positive regulatory T cells to the liver in mice , 2009, Hepatology.

[34]  R. Jessberger,et al.  Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response. , 2009, Immunity.

[35]  A. Rudensky,et al.  Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses , 2009, Nature.

[36]  Keiichiro Suzuki,et al.  Preferential Generation of Follicular B Helper T Cells from Foxp3+ T Cells in Gut Peyer's Patches , 2009, Science.

[37]  B. Malissen,et al.  Heterogeneity of natural Foxp3+ T cells: A committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity , 2009, Proceedings of the National Academy of Sciences.

[38]  Yuka Kanno,et al.  Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. , 2009, Immunity.

[39]  C. Hsieh,et al.  Antigen-specific peripheral shaping of the natural regulatory T cell population , 2008, The Journal of experimental medicine.

[40]  Chen Dong,et al.  CCR6 Regulates the Migration of Inflammatory and Regulatory T Cells1 , 2008, The Journal of Immunology.

[41]  V. Kuchroo,et al.  IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells , 2008, Nature Immunology.

[42]  Christoph Wilhelm,et al.  Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset , 2008, Nature Immunology.

[43]  D. Horwitz.  Regulatory T cells in systemic lupus erythematosus: past, present and future , 2008, Arthritis research & therapy.

[44]  V. Kuchroo,et al.  Role of Th1 and Th17 cells in organ-specific autoimmunity. , 2008, Journal of autoimmunity.

[45]  T. Nomura,et al.  CTLA-4 Control over Foxp3+ Regulatory T Cell Function , 2008, Science.

[46]  E. Shevach,et al.  Costimulatory effects of IL‐1 on the expansion/differentiation of CD4+CD25+Foxp3+ and CD4+CD25+Foxp3– T cells , 2008, Journal of leukocyte biology.

[47]  D. Campbell,et al.  Foxp3+ regulatory T cells maintain immune homeostasis in the skin , 2008, The Journal of experimental medicine.

[48]  D. Vignali,et al.  How regulatory T cells work , 2008, Nature Reviews Immunology.

[49]  S. Zheng,et al.  Cutting Edge: Foxp3+CD4+CD25+ Regulatory T Cells Induced by IL-2 and TGF-β Are Resistant to Th17 Conversion by IL-61 , 2008, The Journal of Immunology.

[50]  M. Roncarolo,et al.  CD4+ T‐regulatory cells: toward therapy for human diseases , 2008, Immunological reviews.

[51]  T. Nomura,et al.  Regulatory T Cells and Immune Tolerance , 2008, Cell.

[52]  E. Chi,et al.  Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. , 2008, Immunity.

[53]  K. Matsushima,et al.  CD4+CD25+ regulatory T cells in the small intestinal lamina propria show an effector/memory phenotype. , 2008, International immunology.

[54]  W. Strober.  Vitamin A rewrites the ABCs of oral tolerance , 2008, Mucosal Immunology.

[55]  P. Hillsamer,et al.  Human Th17 Cells Share Major Trafficking Receptors with Both Polarized Effector T Cells and FOXP3+ Regulatory T Cells1 , 2008, The Journal of Immunology.

[56]  J. O’Shea,et al.  Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation. , 2007, Seminars in immunology.

[57]  Hiromu Ito,et al.  Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model , 2007, The Journal of experimental medicine.

[58]  R. Mason,et al.  Topically Applied 1,25-Dihydroxyvitamin D3 Enhances the Suppressive Activity of CD4+CD25+ Cells in the Draining Lymph Nodes1 , 2007, The Journal of Immunology.

[59]  Y. Belkaid.  Regulatory T cells and infection: a dangerous necessity , 2007, Nature Reviews Immunology.

[60]  I. Campbell,et al.  CXCR3 Signaling Reduces the Severity of Experimental Autoimmune Encephalomyelitis by Controlling the Parenchymal Distribution of Effector and Regulatory T Cells in the Central Nervous System1 , 2007, The Journal of Immunology.

[61]  Y. Belkaid,et al.  Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid , 2007, The Journal of experimental medicine.

[62]  Y. Belkaid,et al.  A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism , 2007, The Journal of experimental medicine.

[63]  Hilde Cheroutre,et al.  Reciprocal TH17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid , 2007, Science.

[64]  S. Ziegler,et al.  IL‐2Rβ links IL‐2R signaling with Foxp3 expression , 2007 .

[65]  L. Boon,et al.  CD4+FoxP3+ regulatory T cells gradually accumulate in gliomas during tumor growth and efficiently suppress antiglioma immune responses in vivo , 2007, International journal of cancer.

[66]  D. Männel,et al.  Interaction of TNF with TNF Receptor Type 2 Promotes Expansion and Function of Mouse CD4+CD25+ T Regulatory Cells1 , 2007, The Journal of Immunology.

[67]  S. Beissert,et al.  IL-10 Controls Ultraviolet-Induced Carcinogenesis in Mice1 , 2007, The Journal of Immunology.

[68]  W. Paul,et al.  Gut flora antigens are not important in the maintenance of regulatory T cell heterogeneity and homeostasis , 2007, European journal of immunology.

[69]  A. Rudensky,et al.  Altering the distribution of Foxp3+ regulatory T cells results in tissue-specific inflammatory disease , 2007, The Journal of experimental medicine.

[70]  S. Bromley,et al.  CCR4-dependent regulatory T cell function in inflammatory bowel disease , 2007, The Journal of experimental medicine.

[71]  W. Strober,et al.  Cutting Edge: Regulatory T Cells Induce CD4+CD25−Foxp3− T Cells or Are Self-Induced to Become Th17 Cells in the Absence of Exogenous TGF-β , 2007, The Journal of Immunology.

[72]  A. Rot,et al.  CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells , 2007, The Journal of experimental medicine.

[73]  A. Hamann,et al.  Induction of organ‐selective CD4+ regulatory T cell homing , 2007, European journal of immunology.

[74]  V. Kuchroo,et al.  TH-17 cells in the circle of immunity and autoimmunity , 2007, Nature Immunology.

[75]  S. Braun,et al.  Identification of a chemokine network that recruits FoxP3(+) regulatory T cells into chronically inflamed intestine. , 2007, Gastroenterology.

[76]  Junliang Pan,et al.  DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27 , 2007, Nature Immunology.

[77]  A. Akbar,et al.  The dynamic co-evolution of memory and regulatory CD4+ T cells in the periphery , 2007, Nature Reviews Immunology.

[78]  Vincent C. Manganiello,et al.  Foxp3-dependent programme of regulatory T-cell differentiation , 2007, Nature.

[79]  A. Rudensky,et al.  Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice , 2007, Nature Immunology.

[80]  Edgar Schmitt,et al.  Epigenetic Control of the foxp3 Locus in Regulatory T Cells , 2007, PLoS biology.

[81]  S. Kang,et al.  FoxP3+ T Cells Undergo Conventional First Switch to Lymphoid Tissue Homing Receptors in Thymus but Accelerated Second Switch to Nonlymphoid Tissue Homing Receptors in Secondary Lymphoid Tissues1 , 2007, The Journal of Immunology.

[82]  T. Tedder,et al.  CD25+CD4+ Regulatory T Cell Migration Requires L-Selectin Expression: L-Selectin Transcriptional Regulation Balances Constitutive Receptor Turnover1 , 2007, The Journal of Immunology.

[83]  M. Farrar,et al.  IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells1 , 2007, The Journal of Immunology.

[84]  Ido D. Weiss,et al.  CD4+CXCR4highCD69+ T Cells Accumulate in Lung Adenocarcinoma , 2006, The Journal of Immunology.

[85]  A. Mcdonald,et al.  CCR8 Expression Identifies CD4 Memory T Cells Enriched for FOXP3+ Regulatory and Th2 Effector Lymphocytes , 2006, The Journal of Immunology.

[86]  Y. Belkaid,et al.  CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence , 2006, The Journal of experimental medicine.

[87]  R. Clark,et al.  The Majority of Human Peripheral Blood CD4+CD25highFoxp3+ Regulatory T Cells Bear Functional Skin-Homing Receptors1 , 2006, The Journal of Immunology.

[88]  D. Littman,et al.  The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells , 2006, Cell.

[89]  A. Caton,et al.  Role of TCR specificity in CD4+CD25+ regulatory T‐cell selection , 2006, Immunological reviews.

[90]  H. Broxmeyer,et al.  Regulation of Trafficking Receptor Expression in Human Forkhead Box P3+ Regulatory T Cells1 , 2006, The Journal of Immunology.

[91]  S. Curbishley,et al.  Epithelial Inflammation Is Associated with CCL28 Production and the Recruitment of Regulatory T Cells Expressing CCR101 , 2006, The Journal of Immunology.

[92]  H. Weiner,et al.  Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells , 2006, Nature.

[93]  Bogdan Tanasa,et al.  Regulation of Th2 differentiation and Il4 locus accessibility. , 2006, Annual review of immunology.

[94]  Michael Loran Dustin,et al.  Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo , 2006, The Journal of experimental medicine.

[95]  Pau Serra,et al.  Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice , 2006, Nature Immunology.

[96]  A. Scheffold,et al.  Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo. , 2005, Blood.

[97]  A. Rudensky,et al.  A function for interleukin 2 in Foxp3-expressing regulatory T cells , 2005, Nature Immunology.

[98]  P. Rutgeerts,et al.  Effects of interleukin 4 on CD25+CD4+ regulatory T cell function. , 2005, Journal of autoimmunity.

[99]  T. Denning,et al.  Cutting Edge: CD4+CD25+ Regulatory T Cells Impaired for Intestinal Homing Can Prevent Colitis12 , 2005, The Journal of Immunology.

[100]  Y. Belkaid,et al.  A Role for CD103 in the Retention of CD4+CD25+ Treg and Control of Leishmania major Infection1 , 2005, The Journal of Immunology.

[101]  M. Kleinewietfeld,et al.  CCR6 expression defines regulatory effector/memory-like cells within the CD25(+)CD4+ T-cell subset. , 2005, Blood.

[102]  Shimon Sakaguchi,et al.  Homeostatic maintenance of natural Foxp3 + CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization , 2005, The Journal of experimental medicine.

[103]  D. Holdstock.  Past, present--and future? , 2005, Medicine, conflict, and survival.

[104]  M. Peakman,et al.  Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. , 2005, Diabetes.

[105]  P. Hillsamer,et al.  Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses. , 2004, The Journal of clinical investigation.

[106]  P. Burkett,et al.  Coordinate Expression and Trans Presentation of Interleukin (IL)-15Rα and IL-15 Supports Natural Killer Cell and Memory CD8+ T Cell Homeostasis , 2004, The Journal of experimental medicine.

[107]  D. Isenberg,et al.  Compromised Function of Regulatory T Cells in Rheumatoid Arthritis and Reversal by Anti-TNFα Therapy , 2004, The Journal of experimental medicine.

[108]  Clare Baecher-Allan,et al.  Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis , 2004, The Journal of experimental medicine.

[109]  P. Farnham,et al.  T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. , 2004, Immunity.

[110]  J. Buer,et al.  Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells , 2004, The Journal of experimental medicine.

[111]  S. Szabo,et al.  Antigen-driven effector CD8 T cell function regulated by T-bet , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[112]  S. Szabo,et al.  Molecular mechanisms regulating Th1 immune responses. , 2003, Annual review of immunology.

[113]  U. Grohmann,et al.  Modulation of tryptophan catabolism by regulatory T cells , 2003, Nature Immunology.

[114]  J. Bluestone,et al.  Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells 1 , 2003, The Journal of Immunology.

[115]  E. Butcher,et al.  Chemokines in the systemic organization of immunity , 2003, Immunological reviews.

[116]  A. Rudensky,et al.  Foxp3 programs the development and function of CD4+CD25+ regulatory T cells , 2003, Nature Immunology.

[117]  Ruslan Medzhitov,et al.  Toll Pathway-Dependent Blockade of CD4+CD25+ T Cell-Mediated Suppression by Dendritic Cells , 2003, Science.

[118]  I. Orme,et al.  Materials and Methods Briefdefinitive Report Disseminated Tuberculosis in Interferon 7 Gene-disrupted Mice , 2022 .

[119]  Y. Belkaid,et al.  CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity , 2002, Nature.

[120]  C. Fathman,et al.  The Subpopulation of CD4+CD25+ Splenocytes That Delays Adoptive Transfer of Diabetes Expresses L-Selectin and High Levels of CCR71 , 2002, The Journal of Immunology.

[121]  S. Szabo,et al.  Distinct Effects of T-bet in TH1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells , 2002, Science.

[122]  J. Bluestone,et al.  B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. , 2000, Immunity.

[123]  Laurie H Glimcher,et al.  A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment , 2000, Cell.

[124]  Fiona Powrie,et al.  An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation , 1999, The Journal of experimental medicine.

[125]  S. Szabo,et al.  T helper differentiation proceeds through Stat1-dependent, Stat4-dependent and Stat4-independent phases. , 1999, Current topics in microbiology and immunology.

[126]  Richard A Flavell,et al.  The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells , 1997, Cell.

[127]  M. Bevan,et al.  Specific immunity to Listeria monocytogenes in the absence of IFN gamma. , 1995, Immunity.

[128]  R. Locksley,et al.  CD4+ effector cells default to the Th2 pathway in interferon gamma- deficient mice infected with Leishmania major , 1994, The Journal of experimental medicine.

[129]  I. Orme,et al.  Disseminated tuberculosis in interferon gamma gene-disrupted mice , 1993, The Journal of experimental medicine.

[130]  F. Ruscetti.  Biology of interleukin-2 , 1984, Survey of immunologic research.

[131]  Stephen T. C. Wong,et al.  Coordination of Early Protective Immunity to Viral Infection by Regulatory T Cells , 2022 .