An Assessment of Modafinil for Vestibular and Aviation-Related Effects

Abstract : The goal of this study was to provide data concerning both the efficacy and the safe-to-fly dosage of a relatively unique compound, modafinil. Previous studies have indicated that modafinil holds promise as an effective wake-promoting agent for military personnel assigned to sustained operations without the common side effects associated with amphetamine-like substances. The present research was conducted to examine whether 200 or 400 mg doses of modafinil have any effect upon human vestibular functioning at night, to verify its cognitive enhancement capabilities during a short-term, sleep-loss setting, and to document the presence/absence of subjective symptoms. Other measures were investigated for possible effects of over-confidence or dehydration.

[1]  D. Batejat,et al.  Disrupted Sleep-Wake Rhythm and Performance: Advantages of Modafinil , 1995 .

[2]  E. Corruble,et al.  Subjective effects of modafinil, a new central adrenergic stimulant in healthy volunteers: a comparison with amphetamine, caffeine and placebo , 1993, European Psychiatry.

[3]  Y. Wong,et al.  Single‐Dose Pharmacokinetics of Modafinil and Methylphenidate Given Alone or in Combination in Healthy Male Volunteers , 1998, Journal of clinical pharmacology.

[4]  W. E. Collins.  Some effects of sleep loss on vestibular responses. , 1988, Aviation, space, and environmental medicine.

[5]  A. Patat,et al.  Effect on postural sway of various benzodiazepine tranquillizers. , 1985, British journal of clinical pharmacology.

[6]  J. J. Collins,et al.  The effects of spaceflight on open-loop and closed-loop postural control mechanisms: human neurovestibular studies on SLS-2 , 2004, Experimental Brain Research.

[7]  John A. Caidwell,et al.  The Effects of Modafinil on Aviator Performance During 40 Hours of Continuous Wakefulness: A UH-60 Helicopter Simulator Study , 1999 .

[8]  T. McLellan,et al.  Effect of modafinil on core temperature during sustained wakefulness and exercise in a warm environment. , 2002, Aviation, space, and environmental medicine.

[9]  P. Barraud,et al.  Effects of modafinil on attentional processes during 60 hours of sleep deprivation , 1998 .

[10]  J. Caldwell,et al.  Efficacy of Dexedrine for maintaining aviator performance during 64 hours of sustained wakefulness: a simulator study. , 2000, Aviation, space, and environmental medicine.

[11]  J. Baranski,et al.  Self‐monitoring cognitive performance during sleep deprivation: effects of modafinil, d‐amphetamine and placebo , 2003, Journal of sleep research.

[12]  J. Baranski,et al.  Modafinil, d‐amphetamine and placebo during 64 hours of sustained mental work. I. Effects on mood, fatigue, cognitive performance and body temperature , 1995, Journal of sleep research.

[13]  D. Batéjat,et al.  Naps and modafinil as countermeasures for the effects of sleep deprivation on cognitive performance. , 1999, Aviation, space, and environmental medicine.

[14]  Jim Horne,et al.  Dimensions to sleepiness. , 1991 .

[15]  E. Weiller,et al.  Antagonism by modafinil of the psychomotor and cognitive impairment induced by sleep-deprivation in 12 healthy volunteers , 1991, European Psychiatry.

[16]  J. Baranski,et al.  Effects of Modafinil on Cognitive Performance During 40 Hr of Sleep Deprivation in a Warm Environment , 2002 .

[17]  Robert S. Kennedy,et al.  Simulator Sickness Questionnaire: An enhanced method for quantifying simulator sickness. , 1993 .

[18]  C D Wylie,et al.  COMMERCIAL MOTOR VEHICLE DRIVER FATIGUE AND ALERTNESS STUDY: PROJECT REPORT , 1996 .

[19]  D. Batéjat,et al.  Interest of modafinil, a new psychostimulant, during a sixty‐hour sleep deprivation experiment , 1995, Fundamental & clinical pharmacology.

[20]  R. Pigeau,et al.  Modafinil, d‐amphetamine and placebo during 64 hours of sustained mental work. II. Effects on two nights of recovery sleep , 1995, Journal of sleep research.

[21]  J. Baranski,et al.  Modafinil During 64 Hr of Sleep Deprivation: Dose-Related Effects on Fatigue, Alertness, and Cognitive Performance , 1998 .

[22]  Analysis of pursuit tracking eye movements in pilots and nonfliers. , 1994, Biomedical sciences instrumentation.

[23]  E J Engelken,et al.  A new approach to the analysis of nystagmus: an application for order-statistic filters. , 1990, Aviation, space, and environmental medicine.

[24]  H Weinberg,et al.  CC130 pilot fatigue during re-supply missions to former Yugoslavia. , 2001, Aviation, space, and environmental medicine.