Frontal EEG alpha band asymmetry as a predictor of reasoning deficiency in depressed people

ABSTRACT Cognitive deficits in depression are mostly apparent in executive functions, especially when integration of information and reasoning is required. In parallel, there are also numerous studies pointing to the frontal alpha band asymmetry as a psychophysiological marker of depression. In this study, we explored the role of frontal alpha asymmetry as a potential factor explaining the cognitive problems accompanying depression. Twenty-six depressed and 26 control participants completed a reasoning task and underwent 5 minutes of electroencephalography recording. In line with the previous studies, depressed people showed difficulties with reasoning but we did not observe the relationship between frontal asymmetry in the alpha band and depression. However, we found that in the depressed group the frontal alpha asymmetry index was characterised by larger variance than in the control group, and it was also a strong predictor of cognitive functioning exclusively in the depressed group. Our results point to the disruption of a psychophysiological balance, reflected in changed frontal alpha asymmetry (into more left-sided frontal asymmetry in the alpha band, reflecting more right-sided cortical activity) as a possible brain correlate of cognitive disturbances present in depressive disorders.

[1]  Enrico Simonotto,et al.  Limbic over-activity in depression during preserved performance on the n-back task , 2006, NeuroImage.

[2]  R. Davidson.  EEG measures of cerebral asymmetry: conceptual and methodological issues. , 1988, The International journal of neuroscience.

[3]  H. Veiel,et al.  A preliminary profile of neuropsychological deficits associated with major depression. , 1997, Journal of clinical and experimental neuropsychology.

[4]  M. Robertson,et al.  Effects of structure and clustering on recall and recognition memory in clinical depression. , 1993, Journal of abnormal psychology.

[5]  Å. Hammar,et al.  Cognitive Functioning in Major Depression – A Summary , 2009, Front. Hum. Neurosci..

[6]  J. Pardo,et al.  Neurocognitive dysfunction in antidepressant-free, non-elderly patients with unipolar depression: alerting and covert orienting of visuospatial attention. , 2006, Journal of affective disorders.

[7]  M. Çiçek,et al.  Interhemispheric asymmetry of EEG alpha activity at rest and during the Wisconsin Card Sorting Test: relations with performance , 2001, Biological Psychology.

[8]  M. Sterman,et al.  Multiband topographic EEG analysis of a simulated visuomotor aviation task. , 1994, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[9]  U. von Hecker,et al.  Effects of subclinical depression and aging on generative reasoning about linear orders: same or different processing limitations? , 2004, Journal of experimental psychology. General.

[10]  R. Davidson.  What does the prefrontal cortex “do” in affect: perspectives on frontal EEG asymmetry research , 2004, Biological Psychology.

[11]  Richel Lousberg,et al.  Validation of a neurofeedback paradigm: manipulating frontal EEG alpha-activity and its impact on mood. , 2014, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[12]  P W Foos,et al.  Effect of presentation order on the construction of linear orders , 1975, Memory & cognition.

[13]  John J. B. Allen,et al.  Frontal EEG Asymmetry as a Promising Marker of Depression Vulnerability: Summary and Methodological Considerations. , 2015, Current opinion in psychology.

[14]  H. Demaree,et al.  The Neuropsychology of Depression: A Literature Review and Preliminary Model , 2003, Neuropsychology Review.

[15]  K. Waterloo,et al.  Verbal memory performance of mildly to moderately depressed outpatient younger adults. , 2006, Journal of affective disorders.

[16]  G. Niederehe,et al.  Depression and memory impairment: a meta-analysis of the association, its pattern, and specificity. , 1995, Psychological bulletin.

[17]  M. Larsson,et al.  Cognitive functions in depressive disorders: evidence from a population-based study , 2004, Psychological Medicine.

[18]  Richard J. Davidson,et al.  Asymmetric brain function, affective style, and psychopathology: The role of early experience and plasticity , 1994, Development and Psychopathology.

[19]  Simon Dymond,et al.  Neural correlates of relational reasoning and the symbolic distance effect: involvement of parietal cortex , 2010, Neuroscience.

[20]  John J. B. Allen,et al.  Frontal EEG asymmetry, emotion, and psychopathology: the first, and the next 25 years , 2004, Biological Psychology.

[21]  P. Johnson-Laird,et al.  Mental Models: Towards a Cognitive Science of Language, Inference, and Consciousness , 1985 .

[22]  B. Sahakian,et al.  Distinct Profiles of Neurocognitive Function in Unmedicated Unipolar Depression and Bipolar II Depression , 2007, Biological Psychiatry.

[23]  Sun-Yong Chung,et al.  Is Alpha Wave Neurofeedback Effective with Randomized Clinical Trials in Depression? A Pilot Study , 2010, Neuropsychobiology.

[24]  G. Sedek,et al.  The Unique Cognitive Limitation in Subclinical Depression: The Impairment of Mental Model Construction , 2010 .

[25]  David A Lewis,et al.  Neural and behavioral substrates of mood and mood regulation , 2002, Biological Psychiatry.

[26]  J. Donoghue,et al.  Frontal and parietal lobe activation during transitive inference in humans. , 2002, Cerebral cortex.

[27]  John J. B. Allen,et al.  Frontal EEG asymmetry as a moderator and mediator of emotion , 2004, Biological Psychology.

[28]  Aneta Brzezicka,et al.  Information Transfer During a Transitive Reasoning Task , 2010, Brain Topography.

[29]  J. Allen,et al.  Resting frontal electroencephalographic asymmetry in depression: inconsistencies suggest the need to identify mediating factors. , 1998, Psychophysiology.

[30]  G. Goodwin,et al.  Cognitive deficits in depression: Possible implications for functional neuropathology , 2001, British Journal of Psychiatry.

[31]  Jordan Grafman,et al.  The functional neuroanatomy of depression: Distinct roles for ventromedial and dorsolateral prefrontal cortex , 2009, Behavioural Brain Research.

[32]  A. Beck,et al.  An inventory for measuring depression. , 1961, Archives of general psychiatry.

[33]  F. Perrin,et al.  Spherical splines for scalp potential and current density mapping. , 1989, Electroencephalography and clinical neurophysiology.

[34]  Christine L Larson,et al.  Functional coupling of simultaneous electrical and metabolic activity in the human brain , 2004, Human brain mapping.

[35]  L. Hasher,et al.  Automatic and effortful processes in memory. , 1979 .

[36]  David N. Towers,et al.  Resting frontal EEG asymmetry as an endophenotype for depression risk: sex-specific patterns of frontal brain asymmetry. , 2010, Journal of abnormal psychology.

[37]  Artur Marchewka,et al.  A role for the right prefrontal and bilateral parietal cortex in four-term transitive reasoning: an fMRI study with abstract linear syllogism tasks. , 2011, Acta neurobiologiae experimentalis.

[38]  J D Smith,et al.  Depression and category learning. , 1993, Journal of experimental psychology. General.

[39]  A. Brzezicka,et al.  Impairments in Mental Model Construction and Benefits of Defocused Attention Distinctive Facets of Subclinical Depression , 2013 .

[40]  Sangmoon Kim,et al.  Depression, anxiety, and resting frontal EEG asymmetry: a meta-analytic review. , 2006, Journal of abnormal psychology.

[41]  Sloutsky,et al.  The Neural Correlates of Logical Thinking: An Event-Related fMRI Study , 2005 .

[42]  G. A. Miller,et al.  Lateralization in Emotion and Emotional Disorders , 1998 .

[43]  B. Ravnkilde,et al.  Cognitive deficits in major depression. , 2002, Scandinavian journal of psychology.

[44]  C. Vázquez,et al.  Automatic and effortful processing in depression. , 1993, Psychological bulletin.

[45]  M. Husain,et al.  Association between depression severity and neurocognitive function in major depressive disorder: a review and synthesis. , 2010, Neuropsychology.

[46]  James K. Kroger,et al.  Recruitment of anterior dorsolateral prefrontal cortex in human reasoning: a parametric study of relational complexity. , 2002, Cerebral cortex.

[47]  T. Brennen,et al.  Automatic and Effortful Processing of Self‐Statements in Depression , 2006, Cognitive behaviour therapy.

[48]  Vladimir M. Sloutsky,et al.  fMRI Evidence for a Three-Stage Model of Deductive Reasoning , 2006, Journal of Cognitive Neuroscience.

[49]  W. Heller,et al.  The puzzle of regional brain activity in depression and anxiety: The importance of subtypes and comorbidity. , 1998 .

[50]  S Davis,et al.  Cognitive processes in depression. , 1982, Journal of clinical psychology.

[51]  P. Hertel.  On the contribution of deficient cognitive control to memory impairment in depression , 1997 .

[52]  R. Porter,et al.  Neuropsychological Impairment in Major Depression: Its Nature, Origin and Clinical Significance , 2007, The Australian and New Zealand journal of psychiatry.

[53]  D. Goldberg,et al.  The heterogeneity of “major depression” , 2011, World psychiatry : official journal of the World Psychiatric Association.

[54]  M. Kofta,et al.  Uncontrollability as a Source of Cognitive Exhaustion , 1998 .

[55]  Christine L Larson,et al.  Imbalance of default mode and regulatory networks during externally focused processing in depression. , 2015, Social cognitive and affective neuroscience.

[56]  R. Sternberg.  Representation and Process in Linear Syllogistic Reasoning. , 1980 .

[57]  E. Harmon-Jones.  Early Career Award. Clarifying the emotive functions of asymmetrical frontal cortical activity. , 2003, Psychophysiology.

[58]  S. Rude,et al.  Depressive deficits in memory: focusing attention improves subsequent recall. , 1991, Journal of experimental psychology. General.

[59]  Andreas Kleinschmidt,et al.  EEG-correlated fMRI of human alpha activity , 2003, NeuroImage.

[60]  A. Hayes.  Introduction to Mediation, Moderation, and Conditional Process Analysis: A Regression-Based Approach , 2013 .

[61]  N. Raoux,et al.  Executive functioning and verbal memory in young patients with unipolar depression and schizophrenia , 1999, Psychiatry Research.

[62]  Leanne M Williams,et al.  Toward an integrated profile of depression: evidence from the brain resource international database. , 2005, Journal of integrative neuroscience.

[63]  A S Gevins,et al.  EEG patterns during 'cognitive' tasks. I. Methodology and analysis of complex behaviors. , 1979, Electroencephalography and clinical neurophysiology.

[64]  S. Nolen-Hoeksema,et al.  The role of rumination in depressive disorders and mixed anxiety/depressive symptoms. , 2000, Journal of abnormal psychology.

[65]  Karl J. Friston,et al.  Regional cerebral blood flow in depression measured by positron emission tomography: the relationship with clinical dimensions , 1993, Psychological Medicine.