Enhanced fluorescence sensing with nano-apertures

We have been studying fluorescence enhancement from labeled oligonucleotides immobilized inside metallic nanoapertures. Fluorescence enhancement is a direct result of the localized field intensity enhancement within these nanoapertures from plasmonic excitation. We have also been developing specific surface chemistries for metallic films to localize capture oligos only inside these nanoapertures. Some of our recent results are overviewed.

[1]  S. Blair,et al.  Modeling Fluorescence Enhancement from Metallic Nanocavities , 2007 .

[2]  M. Heller.  DNA microarray technology: devices, systems, and applications. , 2002, Annual review of biomedical engineering.

[3]  T. Ebbesen,et al.  Nanoaperture-enhanced fluorescence : Towards higher detection rates with plasmonic metals , 2008 .

[4]  P. Lalanne,et al.  Microscopic theory of the extraordinary optical transmission , 2008, Nature.

[5]  H. Lezec,et al.  Control of optical transmission through metals perforated with subwavelength hole arrays. , 1999, Optics letters.

[6]  J. P. Woerdman,et al.  Fano-type interpretation of red shifts and red tails in hole array transmission spectra , 2003, physics/0401054.

[7]  A. Hubin,et al.  Study of the self-assembling of n-octylphosphonic acid layers on aluminum oxide. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[8]  H. Craighead.  Future lab-on-a-chip technologies for interrogating individual molecules , 2006, Nature.

[9]  Steve Blair,et al.  Fluorescence enhancement from an array of subwavelength metal apertures. , 2003, Optics letters.

[10]  Henri Lezec,et al.  Diffracted evanescent wave model for enhanced and suppressed optical transmission through subwavelength hole arrays. , 2004, Optics express.

[11]  A. Dereux,et al.  Selective Surface Modification of SiO 2 -TiO 2 Supports with Phosphonic Acids , 2004 .

[12]  H. Raether.  Surface Plasmons on Smooth and Rough Surfaces and on Gratings , 1988 .

[13]  J. Pendry,et al.  Theory of extraordinary optical transmission through subwavelength hole arrays. , 2000, Physical review letters.

[14]  J. Wenger,et al.  Enhancing Fluorescence with Sub-Wavelength Metallic Apertures , 2010 .