Aryl ureas represent a new class of anti-trypanosomal agents.

[1]  F. Lombardo,et al.  Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. , 2001, Advanced drug delivery reviews.

[2]  Oberg,et al.  Urea-PETT compounds as a new class of HIV-1 reverse transcriptase inhibitors. 3. Synthesis and further structure-activity relationship studies of PETT analogues , 1999, Journal of medicinal chemistry.

[3]  C. Caffrey,et al.  Trypanosoma brucei: killing of bloodstream forms in vitro and in vivo by the cysteine proteinase inhibitor Z-phe-ala-CHN2. , 1999, Experimental parasitology.

[4]  L. Vrang,et al.  Urea-PETT compounds as a new class of HIV-1 reverse transcriptase inhibitors. 3. Synthesis and further structure-activity relationship studies of PETT analogues. , 1999, Journal of medicinal chemistry.

[5]  J. Baker.  Control and surveillance of African trypanosomiasis. Report of a WHO Expert Committee. , 1999, World Health Organization technical report series.

[6]  J. McKerrow,et al.  Cysteine Protease Inhibitors Cure an Experimental Trypanosoma cruzi Infection , 1998, Journal of Experimental Medicine.

[7]  You‐Ming Zhang,et al.  Synthesis of N—Aroyl—N′—hydroxyethyl (Hydroxyphenyl) Thiourea Derivatives Under the Condition of Phase Transfer Catalysis , 1998 .

[8]  J. Thornton,et al.  Tess: A geometric hashing algorithm for deriving 3D coordinate templates for searching structural databases. Application to enzyme active sites , 1997, Protein science : a publication of the Protein Society.

[9]  M. Hommel.  Trypanosomiasis and leishmaniasis: Biology and control , 1997 .

[10]  R J Fletterick,et al.  Structural determinants of specificity in the cysteine protease cruzain , 1997, Protein science : a publication of the Protein Society.

[11]  A. Tsuruoka,et al.  Synthesis and antifungal activity of novel thiazole-containing triazole antifungals. , 1997, Chemical & pharmaceutical bulletin.

[12]  Todd J. A. Ewing,et al.  Critical evaluation of search algorithms for automated molecular docking and database screening , 1997, J. Comput. Chem..

[13]  You‐Ming Zhang,et al.  Phase-Transfer-Catalyzed Synthesis Of N-Aryl-N′-(2-chlorobenzoyl)-thiourea Derivatives , 1997 .

[14]  M Okada,et al.  Studies on aromatase inhibitors. I. Synthesis and biological evaluation of 4-amino-4H-1,2,4-triazole derivatives. , 1996, Chemical & pharmaceutical bulletin.

[15]  R J Fletterick,et al.  Structure-based design of parasitic protease inhibitors. , 1996, Bioorganic & medicinal chemistry.

[16]  H. Broughton,et al.  Controlled modification of acidity in cholecystokinin B receptor antagonists: N-(1,4-benzodiazepin-3-yl)-N'-[3-(tetrazol-5-ylamino) phenyl]ureas. , 1996, Journal of medicinal chemistry.

[17]  J. R. Wu-wong,et al.  Azole endothelin antagonists. 2. Structure-activity studies. , 1996, Journal of medicinal chemistry.

[18]  R J Fletterick,et al.  The crystal structure of cruzain: a therapeutic target for Chagas' disease. , 1995, Journal of molecular biology.

[19]  J M Thornton,et al.  LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. , 1995, Protein engineering.

[20]  PatrickY.-S. Lam,et al.  Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors. , 1994, Science.

[21]  L V Kirchhoff,et al.  American trypanosomiasis (Chagas' disease)--a tropical disease now in the United States. , 1993, The New England journal of medicine.

[22]  F E Cohen,et al.  Structure-based inhibitor design by using protein models for the development of antiparasitic agents. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[23]  R. Fletterick,et al.  Production of crystallizable cruzain, the major cysteine protease from Trypanosoma cruzi. , 1993, The Journal of biological chemistry.

[24]  A. Mills,et al.  Peptide-fluoromethyl ketones arrest intracellular replication and intercellular transmission of Trypanosoma cruzi. , 1993, Molecular and biochemical parasitology.

[25]  P. Rosenthal,et al.  The proteases and pathogenicity of parasitic protozoa. , 1993, Annual review of microbiology.

[26]  J. Scharfstein,et al.  Inhibitors of the major cysteinyl proteinase (GP57/51) impair host cell invasion and arrest the intracellular development of Trypanosoma cruzi in vitro. , 1992, Molecular and biochemical parasitology.

[27]  S. Goldenberg,et al.  Characterization and expression of proteases during Trypanosoma cruzi metacyclogenesis. , 1991, Experimental parasitology.

[28]  L. Libow,et al.  Post-cardiac transplant reactivation of Chagas' disease diagnosed by skin biopsy. , 1991, Cutis.

[29]  I. Larripa,et al.  Assessment of cytogenetic damage in chagasic children treated with benznidazole. , 1988, Mutation research.

[30]  Conrad C. Huang,et al.  The MIDAS display system , 1988 .

[31]  A. R. Hood,et al.  Improved Procedures for the Preparation of Cycloalkyl-, Arylalkyl-, and Arylthioureas , 1988 .

[32]  J. Robertson,et al.  Converting Enzyme Inhibitors in the Treatment of Hypertension , 1987, Journal of cardiovascular pharmacology.

[33]  M. L. Connolly.  Analytical molecular surface calculation , 1983 .

[34]  M. L. Connolly.  Solvent-accessible surfaces of proteins and nucleic acids. , 1983, Science.

[35]  G. Flynn.  Substituent Constants for Correlation Analysis in Chemistry and Biology. , 1980 .

[36]  Julian R. Ullmann,et al.  An Algorithm for Subgraph Isomorphism , 1976, J. ACM.

[37]  K. Elsom.  SULFANILAMIDE AND RELATED COMPOUNDS IN GENERAL PRACTICE , 1941 .

[38]  J. W. W. S.,et al.  Tropical Diseases , 1916, Nature.