In vitro and in vivo characterization of the multiple isoforms of Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferases.

[1]  R. Owens,et al.  The molecular structure of Schistosoma mansoni PNP isoform 2 provides insights into the nucleoside selectivity of PNPs , 2018, bioRxiv.

[2]  A. Cassago,et al.  Schistosoma mansoni displays an adenine phosphoribosyltransferase preferentially expressed in mature female gonads and vitelaria. , 2017, Molecular and biochemical parasitology.

[3]  R. Owens,et al.  Structural and kinetic analysis of Schistosoma mansoni Adenylosuccinate Lyase (SmADSL). , 2017, Molecular and biochemical parasitology.

[4]  J. Brandão-Neto,et al.  Crystal Structure of Schistosoma mansoni Adenosine Phosphorylase/5’-Methylthioadenosine Phosphorylase and Its Importance on Adenosine Salvage Pathway , 2016, PLoS neglected tropical diseases.

[5]  Graeme Winter,et al.  Decision making in xia2 , 2013, Acta crystallographica. Section D, Biological crystallography.

[6]  J. Brandão-Neto,et al.  Adenosine kinase from Schistosoma mansoni: structural basis for the differential incorporation of nucleoside analogues. , 2013, Acta crystallographica. Section D, Biological crystallography.

[7]  R. DeMarco,et al.  Structural and kinetic studies of Schistosoma mansoni adenylate kinases. , 2012, Molecular and biochemical parasitology.

[8]  L. Bird High throughput construction and small scale expression screening of multi-tag vectors in Escherichia coli. , 2011, Methods.

[9]  J. Collins,et al.  Whole mount in situ hybridization methodology for Schistosoma mansoni. , 2011, Molecular and biochemical parasitology.

[10]  Randy J. Read,et al.  Overview of the CCP4 suite and current developments , 2011, Acta crystallographica. Section D, Biological crystallography.

[11]  Vincent B. Chen,et al.  Correspondence e-mail: , 2000 .

[12]  V. Berdini,et al.  Crystal structure of Schistosoma purine nucleoside phosphorylase complexed with a novel monocyclic inhibitor. , 2009, Acta tropica.

[13]  G. Oliva,et al.  Adenosine binding to low-molecular-weight purine nucleoside phosphorylase: the structural basis for recognition based on its complex with the enzyme from Schistosoma mansoni. , 2010, Acta crystallographica. Section D, Biological crystallography.

[14]  Í. Lopes-Cendes,et al.  Schistosoma mansoni: evaluation of an RNAi-based treatment targeting HGPRTase gene. , 2008, Experimental parasitology.

[15]  Rodrigo Lopez,et al.  Clustal W and Clustal X version 2.0 , 2007, Bioinform..

[16]  S. Trapani,et al.  Crystal structure of Leishmania tarentolae hypoxanthine-guanine phosphoribosyltransferase , 2007, BMC Structural Biology.

[17]  C. Caffrey,et al.  Chemotherapy of schistosomiasis: present and future. , 2007, Current opinion in chemical biology.

[18]  Randy J. Read,et al.  Phaser crystallographic software , 2007, Journal of applied crystallography.

[19]  David Alderton,et al.  A versatile ligation-independent cloning method suitable for high-throughput expression screening applications , 2007, Nucleic acids research.

[20]  G. Dillon,et al.  Patterns of gene expression in schistosomes: localization by whole mount in situ hybridization , 2007, Parasitology.

[21]  Alan Fenwick,et al.  Schistosomiasis: challenges for control, treatment and drug resistance , 2006, Current opinion in infectious diseases.

[22]  Jeffrey D Sachs,et al.  Incorporating a Rapid-Impact Package for Neglected Tropical Diseases with Programs for HIV/AIDS, Tuberculosis, and Malaria , 2006, PLoS medicine.

[23]  P. Evans,et al.  Scaling and assessment of data quality. , 2006, Acta crystallographica. Section D, Biological crystallography.

[24]  G. Franco,et al.  Structures for the potential drug target purine nucleoside phosphorylase from Schistosoma mansoni causal agent of schistosomiasis. , 2005, Journal of molecular biology.

[25]  Ming Luo,et al.  Alternative IMP binding in feedback inhibition of hypoxanthine-guanine phosphoribosyltransferase from Thermoanaerobacter tengcongensis. , 2005, Journal of molecular biology.

[26]  Kevin Cowtan,et al.  research papers Acta Crystallographica Section D Biological , 2005 .

[27]  P. Focia,et al.  Interactions at the dimer interface influence the relative efficiencies for purine nucleotide synthesis and pyrophosphorolysis in a phosphoribosyltransferase. , 2004, Journal of molecular biology.

[28]  J. McKerrow,et al.  Schistosoma mansoni: sex-specific modulation of parasite growth by host immune signals. , 2004, Experimental parasitology.

[29]  J. Habbema,et al.  Quantification of clinical morbidity associated with schistosome infection in sub-Saharan Africa. , 2003, Acta tropica.

[30]  Randy J Read,et al.  Electronic Reprint Biological Crystallography Phenix: Building New Software for Automated Crystallographic Structure Determination Biological Crystallography Phenix: Building New Software for Automated Crystallographic Structure Determination , 2022 .

[31]  L. Guddat,et al.  Crystal structures of free, IMP‐, and GMP‐bound Escherichia coli hypoxanthine phosphoribosyltransferase , 2002, Protein science : a publication of the Protein Society.

[32]  C. Bashor,et al.  The structural mechanism of GTP stabilized oligomerization and catalytic activation of the Toxoplasma gondii uracil phosphoribosyltransferase , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[33]  W. Delano The PyMOL Molecular Graphics System , 2002 .

[34]  John P. Huelsenbeck,et al.  MRBAYES: Bayesian inference of phylogenetic trees , 2001, Bioinform..

[35]  P. Focia,et al.  The role for an invariant aspartic acid in hypoxanthine phosphoribosyltransferases is examined using saturation mutagenesis, functional analysis, and X-ray crystallography. , 2001, Biochemistry.

[36]  D. Borhani,et al.  Crystal structures of the Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase-GMP and -IMP complexes: comparison of purine binding interactions with the XMP complex. , 1999, Biochemistry.

[37]  R. Furneaux,et al.  The 2.0 Å structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor , 1999, Nature Structural Biology.

[38]  Yiming Xu,et al.  Ternary complex structure of human hgprtase, prpp, mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding , 1999, Protein science : a publication of the Protein Society.

[39]  P. Focia,et al.  Approaching the transition state in the crystal structure of a phosphoribosyltransferase. , 1998, Biochemistry.

[40]  R. Fletterick,et al.  A 1.4 A crystal structure for the hypoxanthine phosphoribosyltransferase of Trypanosoma cruzi. , 1998, Biochemistry.

[41]  R. Fletterick,et al.  Crystal structure of the hypoxanthine-guanine-xanthine phosphoribosyltransferase from the protozoan parasite Tritrichomonas foetus. , 1996, Biochemistry.

[42]  James C. Sacchettini,et al.  The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP , 1994, Cell.

[43]  T. Allen,et al.  Molecular characterization and overexpression of the hypoxanthine-guanine phosphoribosyltransferase gene from Trypanosoma cruzi. , 1994, Molecular and biochemical parasitology.

[44]  玉一 芦田,et al.  Acta Crystallographica Section D (Biological Crystallography) の発刊に際して , 1993 .

[45]  C. Wang,et al.  Comparing the human and schistosomal hypoxanthine-guanine phosphoribosyltransferases by circular dichroism. , 1993, Biochimica et biophysica acta.

[46]  C. Wang,et al.  Steady-state kinetics of the schistosomal hypoxanthine-guanine phosphoribosyltransferase. , 1992, Biochemistry.

[47]  C. Wang,et al.  Analysis of cDNA encoding the hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) of Schistosoma mansoni; a putative target for chemotherapy. , 1988, Nucleic acids research.

[48]  C. Wang,et al.  Purification and characterization of hypoxanthine-guanine phosphoribosyltransferase from Schistosoma mansoni. A potential target for chemotherapy. , 1986, The Journal of biological chemistry.

[49]  C. Wang,et al.  Purine salvage in Schistosoma mansoni schistosomules. , 1984, Molecular and biochemical parasitology.

[50]  A. W. Senft,et al.  Purine metabolism in the schistosomes: potential targets for chemotherapy. , 1983, Pharmacology & therapeutics.

[51]  J. Richardson,et al.  The anatomy and taxonomy of protein structure. , 1981, Advances in protein chemistry.

[52]  B. Migeon,et al.  Human and mouse hypoxanthine-guanine phosphoribosyltransferase: dimers and tetramers. , 1979, Science.

[53]  A. W. Senft,et al.  Pathways of nucleotide metabolism in Schistosoma mansoni--VII. Inhibition of adenine and guanine nucleotide synthesis by purine analogs in intact worms. , 1977, Biochemical pharmacology.

[54]  A. W. Senft,et al.  Pathways of nucleotide metabolism in Schistosoma mansoni--VI adenosine phosphorylase. , 1975, Biochemical pharmacology.

[55]  A. W. Senft,et al.  Pathways of nucleotide metabolism in schistosoma mansoni. V. Adenosine cleavage enzyme and effects of purine analogues on adenosine metabolism in vitro. , 1974, Biochemical pharmacology.

[56]  A. W. Senft,et al.  Pathways of nucleotide metabolism in Schistosoma mansoni. II. Disposition of adenosine by whole worms. , 1973, Biochemical pharmacology.

[57]  A. W. Senft,et al.  Pathways of nucleotide metabolism in Schistosoma mansoni. 3. Identification of enzymes in cell-free extracts. , 1973, Biochemical pharmacology.

[58]  A. W. Senft,et al.  Pathways of nucleotide metabolism in Schistosoma mansoni. IV. Incorporation of adenosine analogs in vitro. , 1973, Biochemical pharmacology.

[59]  A. W. Senft,et al.  Purine metabolism in Schistosoma mansoni. , 1972, International journal for parasitology.