A Mild, Highly Efficient, andChemoselective Deprotection of Trityl Ethers of Carbohydrates andNucleosides Using Iodine Monobromide

Iodine monobromide in dichloromethane―methanol or acetonitrile constitutes an effective reagent for the deprotection of O-trityl and O-dimethoxytrityl ethers of carbohydrates and nucleosides. Acid-labile functionalities (acetals, O-p-methoxybenzyl ethers, etc.) as well as base-labile groups (esters and amides) are stable under these conditions; and the method has been found to be superior to the hitherto known literature methods.