Novel allelic mutations in murine Serca2 induce differential development of squamous cell tumors.

[1]  H. Masuya,et al.  Novel retinoblastoma mutation abrogating the interaction to E2F2/3, but not E2F1, led to selective suppression of thyroid tumors , 2014, Cancer science.

[2]  H. Masuya,et al.  Novel mouse model for Gardner syndrome generated by a large‐scale N‐ethyl‐N‐nitrosourea mutagenesis program , 2013, Cancer science.

[3]  H. Masuya,et al.  A novel dominant-negative mutation in Gdf5 generated by ENU mutagenesis impairs joint formation and causes osteoarthritis in mice. , 2007, Human molecular genetics.

[4]  N. Darwiche,et al.  The high‐risk benign tumor: Evidence from the two‐stage skin cancer model and relevance for human cancer , 2007, Molecular carcinogenesis.

[5]  D. Bae,et al.  Expression profile of skin papillomas with high cancer risk displays a unique genetic signature that clusters with squamous cell carcinomas and predicts risk for malignant conversion , 2007, Oncogene.

[6]  S. Gruber,et al.  Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway , 2006, Nature Cell Biology.

[7]  Hiroshi Suzuki,et al.  Comprehensive Analysis of Expression and Function of 51 Sarco(endo)plasmic Reticulum Ca2+-ATPase Mutants Associated with Darier Disease* , 2006, Journal of Biological Chemistry.

[8]  C. Byrne.  The focal nature of Darier's disease lesions: calcium pumps, stress, and mutation? , 2006, The Journal of investigative dermatology.

[9]  G. Boivin,et al.  Haploinsufficiency of Atp2a2, encoding the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 Ca2+ pump, predisposes mice to squamous cell tumors via a novel mode of cancer susceptibility. , 2005, Cancer research.

[10]  C. Toyoshima,et al.  Functional and structural roles of critical amino acids within the"N", "P", and "A" domains of the Ca2+ ATPase (SERCA) headpiece. , 2005, Biochemistry.

[11]  Hiromi Nomura,et al.  Lumenal gating mechanism revealed in calcium pump crystal structures with phosphate analogues , 2004, Nature.

[12]  V. Prasad,et al.  Phenotypes of SERCA and PMCA knockout mice. , 2004, Biochemical and biophysical research communications.

[13]  C. Woodworth,et al.  Strain-dependent differences in malignant conversion of mouse skin tumors is an inherent property of the epidermal keratinocyte. , 2004, Carcinogenesis.

[14]  Hiroshi Suzuki,et al.  Distinct Types of Abnormality in Kinetic Properties of Three Darier Disease-causing Sarco(endo)plasmic Reticulum Ca2+-ATPase Mutants That Exhibit Normal Expression and High Ca2+ Transport Activity* , 2004, Journal of Biological Chemistry.

[15]  Hiroshi Masuya,et al.  A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program. , 2004, Human molecular genetics.

[16]  Hiromi Nomura,et al.  Structural changes in the calcium pump accompanying the dissociation of calcium , 2002, Nature.

[17]  Karin Sipido,et al.  Replacement of the Muscle-Specific Sarcoplasmic Reticulum Ca2+-ATPase Isoform SERCA2a by the Nonmuscle SERCA2b Homologue Causes Mild Concentric Hypertrophy and Impairs Contraction-Relaxation of the Heart , 2001, Circulation research.

[18]  G. Boivin,et al.  Squamous Cell Tumors in Mice Heterozygous for a Null Allele of Atp2a2, Encoding the Sarco(endo)plasmic Reticulum Ca2+-ATPase Isoform 2 Ca2+Pump* , 2001, The Journal of Biological Chemistry.

[19]  S. Muallem,et al.  Plasticity and adaptation of Ca2+ signaling and Ca2+‐dependent exocytosis in SERCA2+/− mice , 2001, The EMBO journal.

[20]  G. Shull.  Gene knockout studies of Ca2+-transporting ATPases. , 2000, European journal of biochemistry.

[21]  Steve D. M. Brown,et al.  A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse , 2000, Nature Genetics.

[22]  M. Nakasako,et al.  Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 Å resolution , 2000, Nature.

[23]  Masayoshi Nakasako,et al.  Crystal structure of the calcium pump of sarcoplasmic reticulum at , 2000 .

[24]  T. Strachan,et al.  ATP2A2 mutations in Darier's disease: variant cutaneous phenotypes are associated with missense mutations, but neuropsychiatric features are independent of mutation class. , 1999, Human molecular genetics.

[25]  A. Hovnanian,et al.  Spectrum of novel ATP2A2 mutations in patients with Darier's disease. , 1999, Human molecular genetics.

[26]  R. Smart,et al.  A multihit, multistage model of chemical carcinogenesis. , 1999, Carcinogenesis.

[27]  N. Craddock,et al.  Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease , 1999, Nature Genetics.

[28]  T. Doetschman,et al.  Impaired Cardiac Performance in Heterozygous Mice with a Null Mutation in the Sarco(endo)plasmic Reticulum Ca2+-ATPase Isoform 2 (SERCA2) Gene* , 1999, The Journal of Biological Chemistry.

[29]  Peter Lipp,et al.  Calcium - a life and death signal , 1998, Nature.

[30]  L. D. De Luca,et al.  Topical retinoic acid reduces skin papilloma formation but resistant papillomas are at high risk for malignant conversion. , 1998, Cancer research.

[31]  D. Clarke,et al.  Functional consequences of alterations to amino acids located in the nucleotide binding domain of the Ca2(+)-ATPase of sarcoplasmic reticulum. , 1990, The Journal of biological chemistry.

[32]  D. Clarke,et al.  Location of high affinity Ca2 +-binding sites within the predicted transmembrahe domain of the sarco-plasmic reticulum Ca2+-ATPase , 1989, Nature.

[33]  D. Lowy,et al.  An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue , 1986, Nature.