Genetic and environmental factors in health-related behaviors: studies on Finnish twins and twin families.

Family, twin and adoption studies have provided evidence for familial and genetic influences on individual differences in disease risk and in human behavior. Attempts to identify individual genes accounting for these differences have not been outstandingly successful to date, and at best, known genes account for only a fraction of the familiality of most traits or diseases. More detailed knowledge of the dynamics of gene action and of specific environmental conditions are needed. Twin and twin-family studies with multiple measurements of risk factors and morbidity over time can permit a much more detailed assessment of the developmental dynamics of disease risk and the unfolding of behavioral risk factors.

[1]  J. Kaprio,et al.  Familial and socioregional environmental effects on abstinence from alcohol at age sixteen. , 1999, Journal of studies on alcohol. Supplement.

[2]  J. Kaprio,et al.  Individual differences in adolescent religiosity in Finland: familial effects are modified by sex and region of residence , 1999, Twin Research.

[3]  J. Kaprio,et al.  Drinking or abstaining at age 14? A genetic epidemiological study. , 2001, Alcoholism, clinical and experimental research.

[4]  J. Kaprio,et al.  Hay fever – a Finnish nationwide study of adolescent twins and their parents , 1998, Allergy.

[5]  A. Rissanen,et al.  Tracking of body size from birth to late adolescence: contributions of birth length, birth weight, duration of gestation, parents' body size, and twinship. , 2001, American journal of epidemiology.

[6]  J. Kaprio,et al.  Exploring gene-environment interactions: socioregional moderation of alcohol use. , 2001, Journal of abnormal psychology.

[7]  J. Kaprio,et al.  Familial Aggregation of Leisure-Time Physical Activity - a Three Generation Study , 1997, International journal of sports medicine.

[8]  J. Kaprio,et al.  Associations of health-related behaviors, school type and health status to physical activity patterns in 16 year old boys and girls , 1997, Scandinavian journal of social medicine.

[9]  R. Rose,et al.  Does religiousness explain regional differences in alcohol use in Finland? , 2002, Alcohol and alcoholism.

[10]  J. Kaprio,et al.  Common genetic influences on BMI and age at menarche. , 1995, Human biology.

[11]  J. Kaprio,et al.  Sex Differences in Genetic and Environmental Factors Contributing to Body-Height , 2001, Twin Research.

[12]  J. Nurnberger,et al.  A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA. , 1994, Journal of studies on alcohol.

[13]  Peers, teachers and parents as assessors of the behavioural and emotional problems of twins and their adjustment: the Multidimensional Peer Nomination Inventory. , 1999, Twin research : the official journal of the International Society for Twin Studies.

[14]  J. Kaprio,et al.  Sex differences in genetic and environmental effects on aggression , 2003 .

[15]  J. Kaprio,et al.  Gene-environment interaction in patterns of adolescent drinking: regional residency moderates longitudinal influences on alcohol use. , 2001, Alcoholism, clinical and experimental research.

[16]  Michael C. Neale,et al.  Methodology for Genetic Studies of Twins and Families , 1992 .

[17]  J. Kaprio Lessons from twin studies in Finland. , 1994, Annals of medicine.

[18]  J. Kaprio,et al.  Importance of genetic factors in adolescent asthma: a population-based twin-family study. , 1998, American journal of respiratory and critical care medicine.

[19]  Stuart A. Kauffman,et al.  The origins of order , 1993 .

[20]  J. Kaprio,et al.  Sex Differences in Genetic and Environmental Factors Contributing to Body-Height , 2001, Twin Research.

[21]  J. Kaprio,et al.  Hay fever, asthma and number of older siblings — a twin study , 1997, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[22]  T. Koivula,et al.  The efficiency of a questionnaire in detecting heavy drinkers. , 1990, British journal of addiction.

[23]  J. Kaprio,et al.  Population-based twin registries: illustrative applications in genetic epidemiology and behavioral genetics from the Finnish Twin Cohort Study. , 1990, Acta geneticae medicae et gemellologiae.

[24]  A. Rissanen,et al.  Distribution and heritability of BMI in Finnish adolescents aged 16 y and 17 y: A study of 4884 twins and 2509 singletons , 1999, International Journal of Obesity.

[25]  J. Kaprio,et al.  The heritability of depressive symptoms: multiple informants and multiple measures. , 2002, Journal of child psychology and psychiatry, and allied disciplines.

[26]  J. Kaprio,et al.  Perinatal risk factors for asthma in Finnish adolescent twins , 2000, Thorax.