Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia

Using mouse models overexpressing human TREM2 in microglia, this study shows that WT TREM2 expression reduces amyloid deposition and suppresses disease-associated microglia only during the early amyloid seeding stage, whereas TREM2-R47H exacerbates amyloid burden during the middle amyloid rapid growth stage.

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