Intradermal vaccinations with RNA coding for TAA generate CD8+ and CD4+ immune responses and induce clinical benefit in vaccinated patients.
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H. Rammensee | L. Kanz | T. Holderried | W. Brugger | A. Heine | P. Brossart | A. Stenzl | S. Pascolo | I. Hoerr | M. Horger | O. Maksimovic | S. M. Rittig | M. Haentschel | K. Weimer | M. R. Muller
[1] A. Bringmann,et al. Proteasome inhibition overcomes the resistance of renal cell carcinoma cells against the PPARγ ligand troglitazone , 2009, Cellular and Molecular Life Sciences.
[2] H. Rammensee,et al. Results of the First Phase I/II Clinical Vaccination Trial With Direct Injection of mRNA , 2008, Journal of immunotherapy.
[3] E. Gilboa,et al. Robust CD4+ and CD8+ T cell responses to SIV using mRNA‐transfected DC expressing autologous viral Ag , 2007, European journal of immunology.
[4] H. Rammensee,et al. Spontaneous cellular uptake of exogenous messenger RNA in vivo is nucleic acid-specific, saturable and ion dependent , 2007, Gene Therapy.
[5] L. Kanz,et al. BCR-ABL activity is critical for the immunogenicity of chronic myelogenous leukemia cells. , 2006, Cancer research.
[6] E. Gilboa,et al. Vaccination against the forkhead family transcription factor Foxp3 enhances tumor immunity. , 2007, Cancer research.
[7] G. Bartsch,et al. Antigen-independent immune responses after dendritic cell vaccination , 2007, Cancer Immunology, Immunotherapy.
[8] A. Palucka,et al. Dendritic cell-based vaccination against cancer. , 2006, Hematology/oncology clinics of North America.
[9] Peter Brossart,et al. Immunologic and clinical responses after vaccinations with peptide-pulsed dendritic cells in metastatic renal cancer patients. , 2006, Cancer research.
[10] T. Holderried,et al. Transfection of dendritic cells with in vitro-transcribed CMV RNA induces polyclonal CD8+- and CD4+-mediated CMV-specific T cell responses. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.
[11] L. Kanz,et al. Intradermal RNA-Vaccination of Patients with Metastatic Renal Cell Carcinoma. , 2005 .
[12] P. Brossart,et al. Cotransfection of dendritic cells with RNA coding for HER-2/neu and 4-1BBL increases the induction of tumor antigen specific cytotoxic T lymphocytes , 2005, Cancer Gene Therapy.
[13] H. Rammensee,et al. Production and characterization of amplified tumor-derived cRNA libraries to be used as vaccines against metastatic melanomas. , 2005, Genetic vaccines and therapy.
[14] G. Schuler,et al. Generation of an optimized polyvalent monocyte-derived dendritic cell vaccine by transfecting defined RNAs after rather than before maturation , 2005, The Journal of Immunology.
[15] A. Heine,et al. Processing and presentation of HLA class I and II epitopes by dendritic cells after transfection with in vitro-transcribed MUC1 RNA. , 2005, Blood.
[16] P. Brossart,et al. Dendritic cell-based cancer immunotherapy targeting MUC-1 , 2005, Cancer Immunology, Immunotherapy.
[17] G. Bartsch,et al. Allogeneic dendritic cell vaccination against metastatic renal cell carcinoma with or without cyclophosphamide , 2005, Cancer Immunology, Immunotherapy.
[18] H. Rammensee,et al. Polarization of immunity induced by direct injection of naked sequence-stabilized mRNA vaccines , 2004, Cellular and Molecular Life Sciences CMLS.
[19] S. Pascolo. Messenger RNA-based vaccines , 2004, Expert opinion on biological therapy.
[20] M. Atkins,et al. Fusion Cell Vaccination of Patients with Metastatic Breast and Renal Cancer Induces Immunological and Clinical Responses , 2004, Clinical Cancer Research.
[21] P. Brossart,et al. Induction of chronic lymphocytic leukemia (CLL)-specific CD4- and CD8-mediated T-cell responses using RNA-transfected dendritic cells. , 2004, Blood.
[22] H. Rammensee,et al. Induction of Adipophilin-Specific Cytotoxic T Lymphocytes Using a Novel HLA-A2-Binding Peptide That Mediates Tumor Cell Lysis , 2004, Cancer Research.
[23] L. Kanz,et al. Survivin is a shared tumor-associated antigen expressed in a broad variety of malignancies and recognized by specific cytotoxic T cells. , 2003, Blood.
[24] G. Schuler,et al. Antigen loading of dendritic cells with whole tumor cell preparations. , 2003, Journal of immunological methods.
[25] Donna Niedzwiecki,et al. Immunological and clinical responses in metastatic renal cancer patients vaccinated with tumor RNA-transfected dendritic cells. , 2003, Cancer research.
[26] H. Pandha,et al. Renal-cell carcinoma: tumour markers, T-cell epitopes, and potential for new therapies. , 2003, The Lancet. Oncology.
[27] P. Albers,et al. Allogeneic dendritic cells fused with tumor cells: preclinical results and outcome of a clinical phase I/II trial in patients with metastatic renal cell carcinoma. , 2003, Human gene therapy.
[28] A. Ballestrero,et al. Dendritic cells transfected with tumor RNA for the induction of antitumor CTL in colorectal cancer , 2003, Cancer Gene Therapy.
[29] P. Brossart,et al. Delivery of tumor-derived RNA for the induction of cytotoxic T-lymphocytes , 2003, Gene Therapy.
[30] P. Brossart,et al. Induction of myeloma-specific cytotoxic T cells using dendritic cells transfected with tumor-derived RNA. , 2003, Blood.
[31] G. Bartsch,et al. Immunotherapy of metastatic renal cell carcinoma with tumor lysate-pulsed autologous dendritic cells. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.
[32] P. Robbins,et al. A listing of human tumor antigens recognized by T cells , 2001, Cancer Immunology, Immunotherapy.
[33] L. Kanz,et al. Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells. , 2000, Blood.
[34] H. Rammensee,et al. In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies. , 2000, European journal of immunology.
[35] M Mazumdar,et al. Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[36] H. Rammensee,et al. Identification of HLA-A2-restricted T-cell epitopes derived from the MUC1 tumor antigen for broadly applicable vaccine therapies. , 1999, Blood.
[37] H. Klocker,et al. Human renal‐cell carcinoma tissue contains dendritic cells , 1996, International journal of cancer.
[38] D. Curiel,et al. Characterization of a messenger RNA polynucleotide vaccine vector. , 1995, Cancer research.
[39] G. Acsadi,et al. Direct gene transfer into mouse muscle in vivo. , 1990, Science.
[40] A. Belldegrun,et al. Interleukin 2 expanded tumor-infiltrating lymphocytes in human renal cell cancer: isolation, characterization, and antitumor activity. , 1988, Cancer research.
[41] M. Karno,et al. Renal cell carcinoma. , 1956, Bulletin. Tufts-New England Medical Center.