Adrenergic‐Cholinergic Interaction that Modulates Repolarization in the Atrium is Altered with Aging

Autonomic Modulation of Atrial Repolarization. Introduction: Aging is associated with involution of both limbs of the autonomic nervous system, and the prejunctional and postjunctional effects of adrenergic and cholinergic stimulation are altered with senescence. Hence, postjunctional age‐related changes in adrenergic‐cholinergic interaction are a likely occurrence and may contribute to an altered substrate for arrhythmias.

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