The dependence of the action potential of the frog's heart on the external and intracellular sodium concentration

1. The overshoot of the action potential of the frog's heart was reduced when external sodium chloride was replaced by sucrose. However, the potential decrement was only 17·3 mV for a 10‐fold reduction of sodium as compared with 58 mV expected on the basis of the sodium hypothesis of excitation.

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